(+) naloxone and epinephrine combination therapy
First Claim
1. A composition formulated for dose-wise delivery to a breathing passageway of a human, the composition comprising:
- a carrier solution, the solution containing (+)naloxone; and
the solution also including a pharmacologically effective amount of at least one adrenergic agonist, the (+)naloxone and agonist forming a mixture in the carrier solution.
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Accused Products
Abstract
A composition formulated for dose-wise delivery to a breathing passageway of a human, the composition comprising a carrier solution containing (+)naloxone and a pharmacologically effective amount of at least one adrenergic agonist, the (+)naloxone and agonist forming a mixture in the carrier. The at least one adrenergic agonist is selected from the group consisting of epinephrine, isoproterenol, albuterol, aminophylline, beclomethasone, dyphylline, flunisolide, isoetharine, metaproterenol, oxtriphylline, terbutaline, theophylline, pseudoephedrine, phenylephrine, ephedrine and norepinephrine. That composition is delivered by an atomizer means such as a liquid sprayer or inhaler to treat nasal congestion and asthmatic attacks. Further provided by the invention is a cardiovascular and respiratory stimulating composition for administration to a patient in doses, the composition comprising a pharmacologically effective concentration of (+)naloxone in a carrier solution. If necessary, the composition may also contain a pharmacologically effective amount of at least one adrenergic agonist.
92 Citations
32 Claims
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1. A composition formulated for dose-wise delivery to a breathing passageway of a human, the composition comprising:
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a carrier solution, the solution containing (+)naloxone; and
the solution also including a pharmacologically effective amount of at least one adrenergic agonist, the (+)naloxone and agonist forming a mixture in the carrier solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A cardiovascular and respiratory stimulating composition for administration to a patient in doses, the composition comprising:
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a pharmacologically effective concentration of (+)naloxone in a carrier solution; and
further comprising a pharmacologically effective amount of at least one adrenergic agonist selected from the group consisting of epinephrine, isoproterenol, albuterol, aminophylline, beclomethasone, dyphylline, flunisolide, isoetharine, metaproterenol, oxtriphylline, terbutaline, theophylline, pseudoephedrine, phenylephrine, ephedrine and norepinephrine. - View Dependent Claims (12)
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13. A cardiovascular and respiratory stimulating composition for administration to a patient in doses, the composition comprising:
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a pharmacologically effective concentration of (+)naloxone in a carrier solution; and
wherein a dose is metered to deliver between about 0.1 and 6 μ
g/mL of (+)naloxone.
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14. A method of alleviating breathing passageway compromise in humans, the method comprising:
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providing a carrier solution, the solution containing (+)naloxone and a pharmacologically effective concentration of at least one adrenergic agonist, the (+)naloxone and at least one agonist forming a mixture in the saline solution;
wherein the mixture is contained in an atomizer means to direct an atomized fog of the mixture directly into at least one breathing passageway of the human;
directing a atomized fog dose of the mixture into the at least one breathing passageway of the human. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of stimulating cardiovascular and respiratory output in a human during high-stress situations, the method comprising:
delivering a pharmacologically effective dose of (+)naloxone in a carrier solution, the (+) naloxone thus creating a first composition in the saline solution. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A method of enhancing local vasoconstriction and serve as an adjuvant administered with adrenergic agonists and other pharmaceuticals in order to contain those pharmaceuticals in a high therapeutically effective concentration at their site of administration, the method comprising:
delivering a pharmacologically effective dose of (+)naloxone in a carrier solution, the (+) naloxone thus creating a first composition in the saline solution. - View Dependent Claims (31, 32)
Specification