Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
First Claim
1. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system, the plug comprising:
- a semipermeable body having;
a recess having an interior surface beginning at an opening in the body and ending at a depth surface within the semipermeable body;
a liquid contact surface located opposite the depth surface;
an outer surface located opposite the interior surface, the outer surface having means for sealing an environment of use from an inside of an enclosure of an osmotic delivery system in which the body is insertable;
a predetermined plug thickness defined by the location of the depth surface relative to the liquid contact surface; and
a predetermined wall width defined by the location of the outer surface relative to the interior surface, at least one of the predetermined plug thickness and predetermined wall width for controlling a rate of liquid permeation through the semipermeable body.
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Accused Products
Abstract
Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
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Citations
9 Claims
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1. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system, the plug comprising:
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a semipermeable body having;
a recess having an interior surface beginning at an opening in the body and ending at a depth surface within the semipermeable body;
a liquid contact surface located opposite the depth surface;
an outer surface located opposite the interior surface, the outer surface having means for sealing an environment of use from an inside of an enclosure of an osmotic delivery system in which the body is insertable;
a predetermined plug thickness defined by the location of the depth surface relative to the liquid contact surface; and
a predetermined wall width defined by the location of the outer surface relative to the interior surface, at least one of the predetermined plug thickness and predetermined wall width for controlling a rate of liquid permeation through the semipermeable body. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system, the plug comprising:
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a body formed of a semipermeable material, the body having a recess having an interior surface beginning at an opening in the body and ending at a depth surface within the semipermeable body;
a liquid contact surface located opposite the depth surface;
an outer surface located opposite the interior surface, the outer surface having means for sealing an environment of use from an inside of an enclosure of an osmotic delivery system in which the body is insertable;
a plug thickness defined by the distance from the depth surface to the liquid contact surface; and
a wall width defined by the distance from the outer surface to the interior surface, at least one of the plug thickness and the wall width for controlling a rate of liquid permeation through the semipermeable body.
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9. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system, the plug comprising:
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a semipermeable body having a recess formed in a semipermeable portion of the semipermeable body, the recess having an interior surface beginning at an opening in the body and ending at a depth surface within the semipermeable body;
a liquid contact surface located opposite the depth surface;
an outer surface located opposite the interior surface, the outer surface having means for sealing an environment of use from an inside of an enclosure of an osmotic delivery system in which the body is insertable;
a plug thickness defined by the distance from the depth surface to the liquid contact surface; and
a wall width defined by the distance from the outer surface to the interior surface, at least one of the plug thickness and the wall width for controlling a rate of liquid permeation through the semipermeable body.
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Specification