Iontophoretic material

• US 6,287,484 B1
• Filed: 04/08/1999
• Issued: 09/11/2001
• Est. Priority Date: 11/12/1992
• Status: Expired due to Fees

• Current Assignee: Implemed, Inc.
• Original Assignee: Implemed, Inc.
• Inventors: Rosenberg, Meir, Milder, Fredric, Hausslein, Robert, Keaney, Stephen, Cromwick, Anne Marie
• Primary Examiner(s): KOPEC, MARK T
• Application Number:
  US09/288,606
• Time in Patent Office: 887 Days
• Field of Search: 252/503, 252/512, 252/513, 252/514, 428/407, 424/618, 424/630, 604/93, 604/265
• US Class Current: 252/512
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3662 Femoral shafts
• CPC Class Codes: A61F 2002/2821 Bone stimulation by electromagnetic fields or electric current for enhancing ossification
• CPC Class Codes: A61F 2002/30064 Coating or prosthesis-covering structure made of biodegradable material
• CPC Class Codes: A61F 2310/0052 Coating made of silver or Ag-based alloys
• CPC Class Codes: A61F 2310/00574 Coating or prosthesis-covering structure made of carbon, e.g. of pyrocarbon
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 27/303 Carbon
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/443 with carbon fillers
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/103 Carbon
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 29/126 having a macromolecular matrix
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/084 : Carbon; Graphite
• CPC Class Codes: A61L 31/086 : Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 31/126 : containing carbon fillers
• CPC Class Codes: A61L 31/128 : containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
• CPC Class Codes: A61N 1/056 : Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/20 : continuous direct currents
• CPC Class Codes: A61N 1/303 : Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/306 : Arrangements where at least part of the apparatus is introduced into the body

Abstract

A material is provided that uses controlled electrical current derived from dissimilar galvanic materials to drive oligodynamic metal ions into solution.

Claims

1. An iontophoretic catheter or fluid introduction tube, said iontophoretic catheter or fluid introduction tube comprising an antimicrobial material comprising:

a matrix material;

a plurality of pellets distributed throughout the matrix material;

a first galvanic material distributed on each of the pellets; and

a second galvanic material distributed on each of the pellets.

2. An antimicrobial material comprising:

a matrix material;

a plurality of pellets distributed throughout the matrix material;

a first galvanic material distributed on each of the pellets;

a second galvanic material distributed on each of the pellets; and

a carbon-containing material distributed on at least some of the pellets.

3. An antimicrobial material comprising:

a matrix material;

a plurality of pellets distributed throughout the matrix material;

a first galvanic material distributed on each of the pellets; and

a second galvanic material distributed on each of the pellets, wherein at least one of the plurality of pellets has quantities of the first and second galvanic material distributed thereon such that the first and second galvanic material are not in contact.

4. An antimicrobial material comprising:

a matrix material;

a plurality of pellets distributed throughout the matrix material;

a first galvanic material distributed on each of the pellets;

a second galvanic material distributed on each of the pellets; and

a second galvanic material distributed on each of the pellets, wherein at least one of the plurality of pellets has quantities of the first and second galvanic material distributed thereon such that the first and second galvanic material are in contact, wherein at least one of the plurality of pellets has one of the first and second galvanic material distributed thereon and the other of the first and second galvanic material is distributed on the one of the first and second galvanic material.

5. An antimicrobial material comprising:

a matrix material;

a plurality of pellets distributed throughout the matrix material;

a first galvanic material distributed on each of the pellets;

a second galvanic material distributed on each of the pellets; and

the first galvanic material and the second galvanic material are each metals selected from the group consisting of silver, gold, platinum and copper.

6. The antimicrobial material of claim 5, wherein at least one of the first and second galvanic material is distributed on each of at least some of the plurality of pellets by coating.

7. The antimicrobial material of claim 5, wherein at least one of the first and second galvanic material is distributed on each of at least some of the plurality of pellets by co-precipitation.

8. The antimicrobial material of claim 5, wherein at least one of the plurality of pellets is carbon-based.

9. The antimicrobial material of claim 5, wherein at least one of the plurality of pellets has quantities of first and second galvanic material distributed thereon such that the first and second galvanic material are in contact.

10. The antimicrobial material of claim 9, wherein at least one of the plurality of pellets is comprised of at least two attached pellets, each of the attached pellets having one of the first and second material distributed thereon.