Oral care compositions

• US 6,287,541 B1
• Filed: 09/23/1999
• Issued: 09/11/2001
• Est. Priority Date: 09/23/1998
• Status: Expired due to Fees

• Current Assignee: Chesebrough-Pond'S Usa Co., Division Of Conopco, Inc.
• Original Assignee: Chesebrough-Pond'S Usa Co., Division Of Conopco, Inc.
• Inventors: Wright, Philip, Molloy, Keiran, Creeth, Jonathan E.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US09/401,880
• Time in Patent Office: 719 Days
• Field of Search: 424/49-58, 514/184
• US Class Current: 424/49
• CPC Class Codes: A61K 2800/58 Metal complex; Coordination compounds
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The invention relates to an oral care composition with antiplaque agents. The antiplaque agents are complexes of divalent copper, zinc, iron or tin, or trivalent iron with a specific class of cyclic α-hydroxyketones. A typical example is the copper (II)-ethylmaltol complex. These complexes are more active antiplaque agents that e.g. copper-hinokitiol complexes.

Claims

1. An oral care composition comprising from about 0.001 to about 5% by weight of an antiplaque agent, which is a complex of a metal selected from the group consisting of copper, zinc, iron and tin metal ions complexed to a biologically active ligand which is a cyclic α

-hydroxyketone of the following general formula;

in which X represents O, R₁ represents H or a C₁-C₁₆ branched or straight-chain alkylgroup, and R₂ represents H, linkage between carbon atoms at ring positions 2 and 3 being saturated or unsaturated.

2. An oral care composition according to claim 1, wherein the linkage is unsaturated.

3. An oral care composition according to claim 1, wherein R₁ represents H or a C₁-C₄ branched or straight-chain alkyl group.

4. An oral care composition according to claim 1, wherein the complex is a divalent copper complex.

5. An oral care composition according to claim 1 characterised in that the cyclic α

-hydroxyketone is ethylmaltol.

6. An oral care composition according to claim 1 wherein the complex is a divalent tin complex.

7. An oral care composition according to claim 1, wherein the cyclic α

-hydroxyketone is maltol.

8. An oral care composition according to claim 1 wherein the complex is a divalent copper ethylmaltol complex.

9. A method of inhibiting microbial growth in an oral cavity by applying to the oral cavity an oral care composition comprising from about 0.001 to about 5% by weight of an antiplaque agent, which is a complex of a metal selected from the group consisting of copper, zinc, iron and tin metal ions complexed to a biologically active ligand which is a cyclic α

-hydroxyketone of the following general formula;

in which X represents O, R₁ represents H or a C₁-C₁₆ branched or straight-chain alkylgroup, and R₂ represents H, linkage between carbon atoms at ring positions 2 and 3 being saturated or unsaturated.

10. A method for inhibiting plaque in an oral cavity comprising applying to the oral cavity an oral care composition comprising from about 0.001 to about 5% by weight of an antiplaque agent, which is a complex of a metal selected from the group consisting of copper, zinc, iron and tin metal ions complexed to a biologically active ligand which is a cyclic α

-hydroxyketone of the following general formula;

in which X represents O, R₁ represents H or a C₁-C₁₆ branched or straight-chain alkylgroup, and R₂ represents H, linkage between carbon atoms at ring positions 2 and 3 being saturated or unsaturated.

11. A method for inhibiting gingivitis in an oral cavity comprising applying to the oral cavity an oral care composition comprising from about 0.001 to about 5% by weight of an antiplaque agent, which is a complex of a metal selected from the group consisting of copper, zinc, iron and tin metal ions complexed to a biologically active ligand which is a cyclic α

-hydroxyketone of the following general formula;

in which X represents O, R₁ represents H or a C₁-C₁₆ branched or straight-chain alkylgroup, and R₂ represents H, linkage between carbon atoms at ring positions 2 and 3 being saturated or unsaturated.