Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
First Claim
1. A dual phase polymeric agent-delivery composition comprising:
- (a) a continuous biocompatible gel phase, (b) a discontinuous particulate phase comprising defined microparticles; and
(c) an agent to be delivered contained in both the continuous biocompatible gel phase and the discontinuous particulate phase.
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Abstract
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.
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Citations
39 Claims
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1. A dual phase polymeric agent-delivery composition comprising:
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(a) a continuous biocompatible gel phase, (b) a discontinuous particulate phase comprising defined microparticles; and
(c) an agent to be delivered contained in both the continuous biocompatible gel phase and the discontinuous particulate phase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
(1) providing a dual phase polymeric delivery composition according to claim 1, (2) maintaining said composition as a liquid; and
(3) administering said composition as a liquid to the biological environment, with subsequent gel formation in the biological environment in response to a stimuli.
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34. The method according to claim 33 wherein said administration is via parenteral, ocular, topical, inhalation, transdermal, vaginal, buccal, transmucosal, transurethral, rectal, nasal, oral, pulmonary or aural routes.
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35. The method according to claim 33 wherein the biological environment is a warm blooded animal.
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36. A method for delivering an agent to a biological environment in a controlled manner for a prolonged period of time, comprising the steps of:
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(1) providing a dual phase polymeric delivery composition according to claim 1, (2) gelling said composition; and
(3) administering said composition as a gel to the biological environment.
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37. The method according to claim 36 wherein said administration is via parenteral, ocular, topical, inhalation, transdermal, vaginal, buccal, transmucosal, transurethral, rectal, nasal, oral, pulmonary or aural routes.
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38. The method according to claim 37 wherein the biological environment is a warm blooded animal.
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39. A method for enhancing the stability of a drug during the release from a microparticle delivery system process by providing a dual phase biodegradable polymeric delivery composition according to claim 1.
Specification