Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator

• US 6,287,608 B1
• Filed: 04/11/2000
• Issued: 09/11/2001
• Est. Priority Date: 04/11/2000
• Status: Expired due to Term

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: CHF Solutions, Inc. /Old/ (Baxter International Inc.)
• Inventors: Levin, Howard R., Gelfand, Mark
• Primary Examiner(s): Criares, Theodore J.
• Assistant Examiner(s): KIM, JENNIFER M
• Application Number:
  US09/547,104
• Time in Patent Office: 518 Days
• Field of Search: 424/718
• US Class Current: 424/718
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients

Abstract

A method for treating congestive heart failure (CHF) has been developed that restores kidney renal functions by artificial vasodilation of at least one kidney. A vasodilator drug is locally delivered to the kidney via a kidney perfusion catheter. The drug can be mixed with the patient'"'"'s blood, saline or other suitable solvent and the mixture directly applied to the kidney through the catheter. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient'"'"'s renin-angiotensin system and other neurohormonal substances. The method is applicable to treat chronic and acute CHF.

Claims

1. A method for treatment of a patient suffering from reduced kidney function comprising the steps of:

a. directly infusing at least one kidney of the patient with a fluid containing nitric oxide;

b. by the application of the nitric oxide, increasing blood flow through the at least one kidney with resulting restoration of renal function of said kidney to a predetermined renal function level;

c. after the nitric oxide passes through said at least one kidney, a vasodilator effect of said nitric oxide is reduced and does not cause increased blood flow through other body organs of the patient, and

d. ceasing the infusion of nitric oxide after the predetermined renal functional level has been achieved.

3. A method as in claim 1 comprising the further step of perfusing the at least one kidney.

4. A method as in claim 1 wherein the fluid includes a carrier fluid.

5. A method as in claim 4 wherein the carrier fluid is selected from a group consisting of a saline solution, a krebs-ringer solution and a fluorocarbon emulsion.

21. A method as in claim 4 wherein the carrier fluid is blood taken from the patient and further comprising the step of infusing nitric oxide gas into the blood externally of the patient.

22. A method as in claim 21 wherein the nitric oxide gas is mixed into the blood through a semi-permeable membrane externally of the patient.

23. A method as in claim 4 wherein the carrier fluid is plasma taken from the patient and further comprising the step of infusing the nitric oxide into the plasma externally of the patient.

24. A method as in claim 1 wherein the nitric oxide is substantially eliminated from blood with 10 seconds after infusion into the kidney.

2. A method of treatment of a patient having congestive heart failure comprising the steps of:

a. directly infusing at least one kidney of the patient with a fluid containing nitric oxide;

b. by the application of the nitric oxide, increasing blood flow through the at least one kidney with resulting restoration of renal function of said kidney to a predetermined renal function level;

c. after the nitric oxide passes through said at least one kidney, a vasodilator effect of said nitric oxide becomes reduced and does not cause increased blood flow through other body organs of the patient, and

d. ceasing the infusion of nitric oxide after the predetermined renal functional level has been achieved,

wherein steps (a), (b) and (c) are repeated on a periodic basis to treat congestive heart failure.

6. A method of treatment of a patient having inadequate renal function comprising the steps of:

a. preparing a vasodilator fluid by infusing a gas comprising nitric oxide into a carrier fluid externally of the patient;

b. directly infusing at least one kidney of the patient with the vasodilator fluid;

c. increasing blood flow through the kidney with resulting restoration of renal function of said kidney to a predetermined renal function level;

d. ceasing the infusion of the vasodilator fluid after the predetermined renal functional level has been achieved.

7. A method of treatment of a patient suffering from inadequate renal function comprising the steps of:

a. preparing an artificial vasodilator fluid by infusing a nitric oxide gas into a carrier fluid externally of the patient;

b. directly infusing at least one kidney of the patient with the vasodilator fluid;

c. increasing blood flow through the kidney with resulting restoration of renal function of said kidney to a predetermined renal function level;

d. ceasing the infusion of the artificial vasodilation fluid after a predetermined renal functional level has been achieved.

8. A method as in claim 7 wherein the nitric oxide gas is infused through a membrane in contact with the carrier fluid at a rate dependent on a pressure of a nitric oxide gas source in fluid communication with the membrane.

9. A method to treat congestive heart failure in a patient comprising the steps of:

a. directly infusing at least one kidney in the patient with a fluid containing a nitric oxide;

b. increasing of blood flow through the kidney after step (a);

c. ceasing step (a) after a predetermined renal functional level has been achieved, or a predetermined time of treatment has elapsed.

10. A method to treat congestive heart failure as in claim 9 wherein steps (a), (b), and (c) are repeated on a periodic basis to treat chronic congestive heart failure.

11. A method to treat congestive heart failure in a patient comprising the steps of:

a. infusing at least one kidney in the patient with a fluid containing nitric oxide;

b. ceasing the nitric oxide infusion step after a predetermined renal functional level has been achieved, or a predetermined time of treatment has elapsed.

12. A method to treat congestive heart failure as in claim 11 wherein steps (a) and (b) are repeated on a periodic basis to treat chronic congestive heart failure.

13. A method to treat a kidney in a patient having hypotension induced damage comprising the steps of:

a. infusing the kidney with a fluid containing a vasodilator fluid comprising nitric oxide and a carrier fluid;

b. increasing of blood flow through the kidney after step (a);

c. after the nitric oxide passes through the kidney, a vasodilator effect of said nitric oxide becomes reduced and does not cause increased blood flow through other body organs of the patient, and

d. ceasing step (a) after renal function has been restored.

14. A method as in claim 13 wherein step (a) is performed on said kidney and said patient has a second kidney that is not infused.

15. A method as in claim 13 wherein renal function restoration is determined by the patient achieving a predetermined renal functional level.

16. A method as in claim 13 wherein renal function restoration is determined by the patient achieving an increase in urine output.

17. A method as in claim 13 steps (a) and (b) are repeated on a periodic basis to treat recurring hypotension.

18. A method to treat chronic heart failure in a patient comprising the steps of:

a. infusing a renal artery of the kidney with a fluid containing a nitric oxide, and

b. increasing of blood flow through the kidney after step (a), wherein the nitric oxide becomes inactive in the patient promptly after flowing through the kidney.

19. A method as in claim 18 wherein the nitric oxide is scavenged by blood in the patient.

20. A method as in claim 18 wherein the nitric oxide becomes inactive before inducing systemic hypotension throughout the patient.

25. A method of treatment of a patient having reduced renal function comprising the steps of:

a. preparing a vasodilator solution comprising nitric oxide and carrier fluid;

b. infusing the vasodilator solution into at least one kidney of the patient;

c. the infusion of the vasodilator solution increases blood flow through the at least one kidney with resulting restoration of renal function of said kidney;

d. ceasing the artificial vasodilatation step after a predetermined renal functional level has been achieved.

26. A method of treatment of a patient suffering from reduced kidney function comprising the steps of:

a. infusing at least one kidney of the patient with a vasodilator solution comprising nitric oxide that releases all nitric oxide upon contact with blood in the kidney, and

b. ceasing releasing nitric oxide after the blood treated with the infusion of said vasodilator solution passes through the infused kidney.