Substituted benzolactam compounds as substance P antagonists
First Claim
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1. A compound of the formula or its pharmaceutically acceptable salt, whereinW is —
- S—
CH2—
;
R1, R2 and R3 are independently hydrogen, C1-C3 alkyl C1-C3 alkyl C1-C3 alkoxy or halo C1-C3 alkyl, provided that when W is methylene, both R2 and R3 are not hydrogen;
X is halo, C1-C3 alkoxy, C1-C3 alkyl, halo C1-C3 alkoxy or C1-C3 alkenyl;
Y is imino or oxy;
Q is oxygen or sulfur; and
T is (2S,3S)-2-diphenylmethylquinuclidin-3-yl, (2S,3S)-2-phenylpiperidin-3-yl or (2S,3S)-2-diphenylmethyl-1-azanorbornan-3-yl.
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Abstract
Compounds of formula I are antagonists of Substance P and have activity against CNS and gastrointestinal disorders.
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3 Claims
-
1. A compound of the formula
or its pharmaceutically acceptable salt, wherein W is — - S—
CH2—
;
R1, R2 and R3 are independently hydrogen, C1-C3 alkyl C1-C3 alkyl C1-C3 alkoxy or halo C1-C3 alkyl, provided that when W is methylene, both R2 and R3 are not hydrogen;
X is halo, C1-C3 alkoxy, C1-C3 alkyl, halo C1-C3 alkoxy or C1-C3 alkenyl;
Y is imino or oxy;
Q is oxygen or sulfur; and
T is (2S,3S)-2-diphenylmethylquinuclidin-3-yl, (2S,3S)-2-phenylpiperidin-3-yl or (2S,3S)-2-diphenylmethyl-1-azanorbornan-3-yl. - View Dependent Claims (2, 3)
- S—
Specification