Readable probe array for in vivo use
First Claim
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1. An apparatus comprising:
- an excitation source;
at least one optically detectable probe directed to an analyte, said probe attached to a substrate and situated to contact said analyte, wherein said probe is mixed with an ink to form a probe-filled ink and wherein said probe-filled ink is deposited upon said substrate;
a detector for detecting optical properties of said probe, said detector for converting optical signals representative of the detected optical properties to electrical signals;
wherein said excitation source, said probe, and said detector are adapted for placement together in an area of interest within a body.
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Abstract
A disposable high density optically readable polydeoxynucleotide array with integral fluorescence excitation and fluorescence emission channels is described. The compact array size allows integration into several types of interventional devices such as catheters, guidewires, needles, trocars and may be used intraoperatively. Highly sensitive monitoring of the metabolic and disease pathways of cells in vivo under varying chemical, genetic and environmental conditions is afforded.
294 Citations
24 Claims
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1. An apparatus comprising:
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an excitation source;
at least one optically detectable probe directed to an analyte, said probe attached to a substrate and situated to contact said analyte, wherein said probe is mixed with an ink to form a probe-filled ink and wherein said probe-filled ink is deposited upon said substrate;
a detector for detecting optical properties of said probe, said detector for converting optical signals representative of the detected optical properties to electrical signals;
wherein said excitation source, said probe, and said detector are adapted for placement together in an area of interest within a body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An apparatus comprising:
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an excitation source;
at least one optically detectable probe directed to an analyte, said probe situated to contact said analyte;
a detector for detecting optical properties of said probe, said detector for converting optical signals representative of the detected optical properties to electrical signals;
wherein said excitation source, said probe, and said detector are disposed within a body-insertable device that is to be positioned in an area of interest within a body, said body-insertable device comprising a lumen positioned such that said lumen is capable of introducing to said area of interest a lysing system. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification