Device for metered administration of an injectable product

• US 6,290,679 B1
• Filed: 05/14/1999
• Issued: 09/18/2001
• Est. Priority Date: 05/14/1999
• Status: Expired due to Fees

• Current Assignee: TecPharma Licensing AG (Ypsomed Holding AG)
• Original Assignee: Disetronic Licensing Ag (Roche Holding AG)
• Inventors: Heiniger, Hanspeter, Hostettler, Peter
• Primary Examiner(s): Nguyen, Anhtuan T.
• Assistant Examiner(s): Lam, Ann Y.
• Application Number:
  US09/311,438
• Time in Patent Office: 858 Days
• Field of Search: 604/136, 604/191, 604/195, 604/196, 604/207, 604/208, 604/218, 604/223, 604/226, 604/232, 604/233
• US Class Current: 604/208
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/31595 Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3257 Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means
• CPC Class Codes: A61M 5/3272 having projections following labyrinth paths
• CPC Class Codes: A61M 5/3287 Accessories for bringing the needle into the body; Automatic needle insertion A61M5/20, A61M5/31525 take precedence

Abstract

The present invention provides a device for metered administration of an injectable product including a base section, a container, a drive unit including a driven member projecting into the container, and a metering device for setting the path length of displacement of the driven member in relation to the base section upon actuation of the drive unit, wherein the metering device includes a first and second metering structure.

Claims

1. A device for metered administration of an injectable product, comprising:

(a) a base section,

(b) a container arranged in said base section, from which container a dose of the injectable product is dispensed through a needle by advancing in a forward direction at least one piston arranged in said container,

(c) a drive unit comprising a driven member projecting into the container, said driven member advancing the piston in said forward direction upon actuation of the drive unit, and

(d) a metering device for choosing a length over which the driven member is displaced in relation to the base section, said metering device comprising a first metering mechanism and a second metering mechanism, the second metering mechanism being adjustable in relation to the first metering mechanism, wherein the first and second metering mechanisms are arranged in said container and metering is effected by interaction of the first and the second metering mechanisms within said container, and wherein said first metering mechanism is formed by a recess in a cylindrical jacket surface, wherein said recess comprises two side walls extending in said forward direction, and a connection of these side walls comprising a wall section extending in circumferential direction and against said forward direction, said wall section serving as stop for said second metering mechanism.

6. The device as set forth in claim 1, wherein said second metering mechanism is directly connected to said driven member.

7. The device as set forth in claim 1, wherein the device is an auto-injection device and further wherein said container is advanced in relation to said base section by said driven member in order to insert a needle carried by the container.

8. The device as set forth in claim 7, wherein a component of the metering device comprising said first metering mechanism, serves as a transfer member, transferring a forward movement of said driven member to the container, until said container has reached a forward position in relation to said base section.

2. A device for metered administration of an injectable product, comprising:

(a) a base section,

(b) a container arranged in said base section, from which container a dose of the injectable product is dispensed through a needle by advancing in a forward direction at least one piston arranged in said container,

(c) a drive unit comprising a driven member projecting into the container, said driven member advancing the piston in said forward direction upon actuation of the drive unit, and

(d) a metering device for choosing a length over which the driven member is displaced in relation to the base section, said metering device comprising a first metering means and a second metering means, the second metering means being adjustable in relation to the first metering means, wherein the first and second metering means are arranged in said container and metering is effected by interaction of the first and the second metering means within said container, wherein said first metering means acts as a guide channel for said second metering means, and wherein said guide channel is provided by joining together two cylindrical bodies, wherein at least one of these bodies is a sleeve body having an end face forming a side wall of said guide channel.

9. The device as set forth in claim 2, wherein said second metering means contacts a stop during advancement of said driven member, thus limiting the length of the displacement of the driven member.

10. The device as set forth in claim 2, wherein said second metering means is directly connected to said driven member.

11. The device as set forth in claim 2, wherein the device is an auto-injection device and further wherein said container is advanced in relation to said base section by said driven member in order to insert a needle carried by the container.

12. The device as set forth in claim 11, wherein a component of the metering device comprising said first metering means, serves as a transfer member, transferring a forward movement of said driven member to the container, until said container has reached a forward position in relation to said base section.

3. A device for metered administration of an injectable product, comprising:

(a) a base section.

(b) a container arranged in said base section, from which container a dose of the injectable product is dispensed through a needle, wherein said container is a multi-chamber ampoule comprising at least two chambers arranged generally axially with respect to the ampoule one behind the other, said chambers being separated from each other by a frontal piston and being closed by a rear piston, said rear piston being displaced towards said frontal piston when the contents of the two chambers are mixed by means of a mixing member projecting into said container, said mixing member being forwardly displaceable in said container,

(c) a drive unit comprising a driven member projecting into the container, said driven member advancing the piston in said forward direction upon actuation of the drive unit, and

(d) a metering device for choosing a length over which the driven member is displaced in relation to the base section, said metering device comprising a first metering means and a second metering means, the second metering means being adjustable in relation to the first metering means, wherein the first and second metering means are arranged in said container and metering is effected by interaction of the first and the second metering means within said container, wherein said first metering means comprises said mixing member.

13. The device as set forth in claim 3, wherein said second metering means contacts a stop during advancement of said driven member, thus limiting the length of the displacement of the driven member.

14. The device as set forth in claim 3, wherein said second metering means is directly connected to said driven member.

15. The device as set forth in claim 3, wherein the device is an auto-injection device and further wherein said container is advanced in relation to said base section by said driven member in order to insert a needle carried by the container.

16. The device as set forth in claim 15, wherein a component of the metering device comprising said first metering means, serves as a transfer member, transferring a forward movement of said driven member to the container, until said container has reached a forward position in relation to said base section.

4. A device for metered administration of an injectable product, comprising:

(a) a base section,

(b) a container arranged in said base section, from which container a dose of the injectable product is dispensed through a needle by advancing in a forward direction at least one piston arranged in said container,

(c) a drive unit comprising a driven member projecting into the container, said driven member advancing the piston in said forward direction upon actuation of the drive unit, and

(d) a metering device for setting a length over which the driven member is displaced in relation to the base section, said metering device comprising a first metering means and a second metering means, the second metering means being adjustable in relation to the first metering means, wherein the first and second metering means are arranged in said container and metering is effected by interaction of the first and the second metering means within said container, wherein the device is an auto-injection device and further wherein said container is advanced in relation to said base section by said driven member in order to insert a needle carried by the container.

5. The device as set forth in claim 4, characterized in that a component of the metering device comprising said first metering means, serves as a transfer member, transferring a forward movement of said driven member to the container, until said container has reached a forward position in relation to said base section.