Sample injector for high pressure liquid chromatography
First Claim
1. An apparatus for injecting a sample into a chromatographic column, comprising:
- a source of high pressure joined at a common junction to the inlet of the chromatographic column; and
a sample injector joined to the common junction, said sample injector comprising at least two elements combined in a series arrangement and connected to a common power supply, wherein each element comprises a container having an inlet end and an outlet end, the container filled with a dielectric material forming a porous bed therein.
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Accused Products
Abstract
Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.
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Citations
11 Claims
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1. An apparatus for injecting a sample into a chromatographic column, comprising:
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a source of high pressure joined at a common junction to the inlet of the chromatographic column; and
a sample injector joined to the common junction, said sample injector comprising at least two elements combined in a series arrangement and connected to a common power supply, wherein each element comprises a container having an inlet end and an outlet end, the container filled with a dielectric material forming a porous bed therein. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An apparatus for the high pressure injection of a sample into a chromatography column, comprising:
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a substrate fabricated to define a microchannel system disposed thereon, the microchannel system comprising, in combination, a source of high pressure joined at a common junction to the inlet of the chromatography column; and
a sample injector joined to the to the common junction, said sample injector comprising at least two elements combined in a series arrangement and connected to a common power supply, wherein each element comprises a container having an inlet end and an outlet end, the container filled with a dielectric material forming a porous bed therein. - View Dependent Claims (9, 10, 11)
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Specification