Antimicrobial compositions comprising a benzoic acid analog and a metal salt

• US 6,294,186 B1
• Filed: 10/19/1999
• Issued: 09/25/2001
• Est. Priority Date: 06/04/1997
• Status: Expired due to Term

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Beerse, Peter William, Page, Steven Hardy, Morgan, Jeffrey Michael, Biedermann, Kimberly Ann, Mobley, Michael Joseph
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US09/421,084
• Time in Patent Office: 707 Days
• Field of Search: 424/405, 424/401, 514/156, 514/162, 514/859
• US Class Current: 424/405
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 43/36 five-membered rings
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/16 for influenza or rhinoviruses
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: D21H 21/36 Biocidal agents, e.g. fungicidal, bactericidal, insecticidal agents
• CPC Class Codes: D21H 27/32 with materials applied between the sheets attaching together paper or cardboard sheets B31F5/00; adhesives C09J

Abstract

The present invention relates to antimicrobial compositions which provide enhanced immediate as well as residual anti-viral and antibacterial efficacy. The antimicrobial compositions of the present invention provide previously unseen residual effectiveness against Gram negative bacteria, Gram positive bacteria, and viruses, fungi, and improved immediate germ reduction upon use. These compositions comprise: a) a safe and effective amount of a benzoic acid analog; b) a safe and effective amount of a metal salt; and c) a dermatologically acceptable carrier for the acid and salt wherein said composition has a pH of from about 1 to about 7. The invention further relates to methods of use for the present compositions as well as antimicrobial products which incorporate the compositions.

Claims

1. An antimicrobial composition comprising:

a) a safe and effective amount of benzoic acid analog;

b) a safe and effective amount of a metal salt; and

c) a dermatologically acceptable carrier for the acid and salt wherein said composition has a pH of from about 1 to about 7 and is substantially free of para-amino salicylic acid.

2. The composition of claim 1 wherein said composition is effective against viruses selected from the group consisting of rhinoviruses, adenoviruses, rotaviruses, herpes viruses, respiratory syncytial viruses, coronaviruses, parainfluenza viruses, enteroviruses, influenza viruses, and combinations thereof.

3. The composition of claim 1 wherein said composition comprises from about 0.01% to about 20%, by weight of said composition, of said benzoic acid analog.

4. The composition of claim 1 wherein said composition comprises from a safe and effective amount of a metal salt such that the composition comprises from about 0.001% to about 20%, by weight of said composition, of a final metal ion.

5. The composition of claim 1 wherein said benzoic acid analog is selected from the group consisting of benzoic acid, salicylic acid, 2-nitrobenzoic acid, thiosalicylic acid, 2,6-dihydroxybenzoic acid, 3-hydroxybenzoic acid, 5-nitrosalicylic acid, 5-bromosalicylic acid, 5-iodosalicylic acid, 5-fluorosalicylic acid, 3-chlorosalicylic acid, 4-chlorosalicylic acid, 5-chlorosalicylic acid, phthalic acid, and combinations thereof.

6. The composition of claim 4 wherein said benzoic acid analog is selected from the group consisting of benzoic acid, salicylic acid, and combinations thereof.

7. The composition of claim 1 wherein said metal salt comprises metals selected from the group consisting of Groups I (A, B), II (A, B), III A, IV(A,B), VIB, VIII, rare earth compounds, and combinations thereof.

8. The composition of claim 1 wherein said metal salt comprises metals selected from the group consisting of Mn, Ag, Zn, Sn, Fe, Cu, Al, Ni, Co, Ti, Zr, Cr, La, Bi, K, Cd, Yb, Dy, Nd, Ce, Tl, Pr, and combinations thereof.

9. The composition of claim 1 wherein said metal salt is selected from the group consisting of tin salts, iron salts, copper salts, silver salts, and combinations thereof.

10. The composition of claim 9 wherein said copper salt is selected from the group consisting of copper sulfate, copper chloride, copper nitrate, copper acetate, copper bromide, copper iodide, and combinations thereof.

11. The composition of claim 9 wherein said silver salt is selected from the group consisting of silver nitrate, silver chloride, silver acetate, silver sulfate, and combinations thereof.

12. The composition of claim 9 wherein said tin salt is selected from the group consisting of tin chloride, tin acetate, tin bromide, tin iodide, tin sulfate, tin fluoride, and combinations thereof.

13. The composition of claim 9 wherein said iron salt is selected from the group consisting of iron sulfate, iron acetate, iron bromide, iron chloride, iron fluoride, iron iodide, and combinations thereof.

14. The composition of claim 1 wherein said carrier comprises an alcohol solution.

15. The composition of claim 14 wherein said alcohol solution comprises monohydric alcohols, dihydric alcohols, and combinations thereof.

16. The composition of claim 1 wherein said composition further comprises a surfactant.

17. The composition of claim 16 wherein said surfactant is selected from the group consisting of anionic surfactants, cationic surfactants, amphoteric surfactants, and combinations thereof.

20. A method of killing bacteria, wherein said method comprises topically applying the composition of claim 1 to an area in need of such treatment.

21. A method of inactivating viruses, wherein said method comprises topically applying the composition of claim 1 to an area in need of such treatment.

22. A method of providing residual antibacterial efficacy, wherein said method comprises topically applying said composition of claim 1 to an area in need of such treatment.

23. A method of providing residual anti-viral efficacy, wherein said method comprises topically applying said composition of claim 1 to an area in need of such treatment.

24. A method of preventing and/or treating a common cold or associated respiratory disease in a mammal where said disease is caused by a rhinovirus, said method comprising topically applying the composition of claim 1 to an area of the mammal which is infected with said rhinovirus.

25. A method of preventing and/or treating bacteria-related diseases in a mammal which result from contact with a bacteria-infected surface, said method comprising topically applying the composition of claim 1 to an area of the mammal which is infected with said bacteria.

26. An antimicrobial product comprising said composition of claim 1.

27. The product of claim 26 wherein said product is a personal care product.

28. The product of claim 27 wherein said personal care product is selected from the group consisting of hand soaps, hand sanitizers, body washes, shower gels, body lotions, and combinations thereof.

29. The product of claim 26 wherein said product is a household care product.

30. The product of claim 29 wherein said product is a household care product selected from the group consisting of hard surface cleaners, dish detergents, and floor waxes.

31. The product of claim 26 wherein said product is a wipe product suitable for personal care use.

32. The product of claim 26 wherein said product is a wipe product suitable for household cleaning.

33. The product of claim 26 wherein said product is a facial tissue.

34. The product of claim 26 wherein said product is an intranasal spray.

36. A method of improving the overall health of a mammal by reducing exposure to viruses and/or bacteria, said method comprising the steps of:

a) topically applying the composition of claim 1 to a surface which is prone to viral and/or bacterial contamination; and

b) allowing said surface to dry.

37. A method of reducing absenteeism of persons from school and/or work wherein said absenteeism is caused by bacterial or viral illness, said method comprising;

a) topically applying the composition of claim 1 to a bodily surface of a person which is prone to viral and/or bacterial contamination;

b) rubbing said surface for at least 15 seconds; and

c) allowing said surface to dry.

38. The method of claim 37 wherein said bodily surface is one or more hands.

39. A method of preventing and/or treating dandruff, said method comprising the step of topically applying the composition of claim 1 to a mammalian scalp in need of such treatment.

40. A method of preventing and/or treating acne, said method comprising the step of topically applying the composition of claim 1 to a mammalian keratinous tissue in need of such treatment.

18. An antimicrobial composition comprising:

a) a safe and effective amount of a metal-benzoic acid analog complex; and

b) a dermatologically acceptable carrier for said complex wherein said composition has a pH of from about 1 to about 7 and is substantially free of para-amino salicylic acid.

19. The composition of claim 18 wherein said metal-benzoic acid analog complex is a product of a metal selected from the group consisting of copper, silver, tin, iron, and combinations thereof;

and a benzoic acid analog.

35. An antimicrobial personal care kit useful for deactivating bacteria and viruses which cause common colds, respiratory or gastrointestinal illnesses, wherein said kit comprises:

a) a facial tissue comprising a composition comprising;

1) a safe and effective amount of benzoic acid analog;

2) a safe and effective amount of a metal salt; and

3) a dermatologically acceptable carrier for the acid and salt; and

b) an intranasal spray comprising;

1) a safe and effective amount of benzoic acid analog;

2) a safe and effective amount of a metal salt; and

3) a dermatologically acceptable carrier for the acid and salt; and

wherein said tissue and said intranasal spray are used in conjunction with one another.

41. A method of providing residual anti-viral efficacy, said method comprises topically applying to an area in need of such treatment a composition comprising a safe and effective amount of a benzoic acid analog and a dermatologically acceptable carrier and wherein said composition is essentially free of metal salts.

42. A method of providing residual antibacterial efficacy, wherein said method comprises topically applying to an area in need of such treatment a composition comprising a safe and effective amount of a benzoic acid analog and a dermatologically acceptable carrier and wherein said composition is essentially free of metal salts.

43. A method of preventing and/or treating a common cold or associated respiratory disease in a mammal where said disease is caused by a rhinovirus, said method comprising topically applying to an area of the mammal which is infected with said rhinovirus a composition comprising a safe and effective amount of a benzoic acid analog and a dermatologically acceptable carrier and wherein said composition is essentially free of metal salts and wherein said area exhibits residual anti-viral activity.

44. The method of claim 43 wherein said area is selected from the group consisting of one or more hands, a nose, and a nasal canal.

45. A method of preventing and/or treating bacteria-related diseases in a mammal which result from contact with a bacteria-infected surface, said method comprising topically applying to an area of the mammal which is infected with said bacteria a composition comprising a safe and effective amount of benzoic acid analog and a dermatologically acceptable carrier and wherein said composition is essentially free of metal salts and wherein said area exhibits residual antibacterial activity.

46. A method of improving the overall health of a mammal by reducing exposure to viruses and/or bacteria, said method comprising the steps of:

a) topically applying to a surface which is prone to viral and/or bacterial contamination a composition comprising a safe and effective amount of a benzoic acid analog and a dermatologically acceptable carrier and wherein said composition is essentially free of metal salts; and

(b) allowing said surface to dry wherein said surface exhibits residual anti-viral and/or anti-bacterial activity.

47. The method of claim 46 wherein said area is selected from the group consisting of one or more hands, a nose, and a nasal canal.

48. A method of reducing absenteeism of persons from school and/or work wherein said absenteeism is caused by bacterial or viral illness, said method comprising;

a) topically applying to a surface which is prone to viral and/or bacterial contamination a composition comprising a safe and effective amount of a benzoic acid analog and a dermatologically acceptable carrier and wherein said composition is essentially free of metal salts;

b) rubbing said surface for at least 15 seconds; and

c) allowing said surface to dry wherein said surface exhibits residual anti-viral and/or anti-bacterial activity.

49. The method of claim 48 wherein said area is selected from the group consisting of one or more hands, a nose, and a nasal canal.