Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers

• US 6,294,202 B1
• Filed: 10/06/1994
• Issued: 09/25/2001
• Est. Priority Date: 10/06/1994
• Status: Expired due to Term

• Current Assignee: Genzyme Corporation (Sanofi )
• Original Assignee: Genzyme Corporation (Sanofi )
• Inventors: Burns, James W., Greenawalt, Keith E., Masi, Louis
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US08/318,987
• Time in Patent Office: 2,546 Days
• Field of Search: 424/426, 424/488, 424/443, 514/777, 514/54, 536/123.1, 536/53, 536/55.2, 536/55.1, 525/54.3
• US Class Current: 424/488
• CPC Class Codes: A61B 90/00 Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges protective face masks A41D13/11; surgeon's or patient's gowns or dresses A41D13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M1/00
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C08L 1/28 Alkyl ethers
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 5/10 Heparin; Derivatives thereof
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Biocompatible compositions comprising polyanionic polysaccharides such as Hyaluronic Acid combined with hydrophobic bioabsorbable polymers as well as methods for making and using the compositions are described.

Claims

1. A water-insoluble biocompatible composition comprising a non-covalently crosslinked water-insoluble polyanionic polysaccharide derivative combined with a hydrophobic bioabsorbable polymer, wherein said composition is produced by:

a) reacting hyaluronic acid with an activating agent to form a non-covalently crosslinked water-insoluble hyaluronic acid derivative bearing an i) amide or amine group or ii) N-acyl urea group; and

b) non-covalently combining said non-covalently crosslinked water-insoluble hyaluronic acid derivative with a polyglycolide to form said water-insoluble biocompatible composition.

2. The composition of claim 1, said composition further comprising a second polyanionic polysaccharide derivative, wherein the second polyanionic polysaccharide derivative is produced by a method comprising reacting a second polyanionic polysaccharide with the activating agent, and wherein the second poly anionic polysaccharide is not hyaluronic acid.

3. The composition of claim 2, wherein said second polyanionic polysaccharide is carboxymethylcellulose, and said activating agent is a carbodiimide.

4. The composition of claim 2, wherein said second polyanionic polysaccharide is carboxymethylamylose, and said activating agent is a carbodiimide.

5. The composition of claim 1, wherein said composition is in the form of a membrane.

6. The composition of claim 2, wherein said composition is in the form of a membrane.

7. The composition of claim 1, wherein said composition is in the form of a foam.

8. The composition of claim 2, wherein said composition is in the form of a foam.

9. The composition of claim 1, wherein said composition is in the form of a fiber.

10. The composition of claim 2, wherein said composition is in the form of a fiber.

11. The composition of claim 1, wherein said composition is in the form of a gel.

12. The composition of claim 2, wherein said composition is in the form of a gel.

13. The composition of claim 1, further comprising a drug.

14. The composition of claim 2, further comprising a drug.

15. The composition of claim 13, wherein said drug is chosen from the group consisting of proteins, biopolymers, steroids, non-steroidal anti-inflammatory drugs, cytotoxic agents, antibiotics, and oligonucleotides.

16. The composition of claim 14, wherein said drug is chosen from the group consisting of proteins, biopolymers, steroids, non-steroidal anti-inflammatory drugs, cytotoxic agents, antibiotics, and oligonucleotides.

17. The composition of claim 13, wherein said drug is a growth factor.

18. The composition of claim 14, wherein said drug is a growth factor.

19. The composition of claim 13, wherein said drug is an antibiotic.

20. The composition of claim 14, wherein said drug is an antibiotic.

21. The composition of claim 1, further comprising biological cells.

22. The composition of claim 21, wherein said composition is admixed with said cells.

23. The composition of claim 21, wherein said composition is infiltrated with said cells.

24. The composition of claim 21, wherein said cells are derived from a mammal.

25. The composition of claim 24, wherein said mammal is a human.

26. The composition of claim 21, wherein said cells comprise fibroblasts.

27. The composition of claim 21, wherein said cells comprise osteocytes.

28. The composition of claim 21, wherein said cells comprise chondrocytes.

29. The composition of claim 21, wherein said cells comprise keratinocytes.

30. The composition of claim 21, wherein said cells comprise tenocytes.

31. The composition of claim 21, wherein said cells comprise non-differentiated mesenchymal cells.

32. The composition of claim 21, wherein said cells comprise a mixture of at least two cell types.

33. The composition of claim 21, further comprising a drug.

34. The composition of claim 33, wherein said drug is a growth factor.

35. The composition of claim 33, wherein said drug is an antibiotic.

36. The composition of claim 2, further comprising biological cells.

37. The composition of claim 36, wherein said composition is admixed with said cells.

38. The composition of claim 36, wherein said composition is infiltrated with said cells.

39. The composition of claim 36, wherein said cells are derived from a mammal.

40. The composition of claim 39, wherein said mammal is a human.

41. The composition of claim 36, wherein said cells comprise fibroblasts.

42. The composition of claim 36, wherein said cells comprise osteocytes.

43. The composition of claim 36, wherein said cells comprise chondrocytes.

44. The composition of claim 36, wherein said cells comprise keratinocytes.

45. The composition of claim 36, wherein said cells comprise tenocytes.

46. The composition of claim 36, wherein said cells comprise non-differentiated mesenchymal cells.

47. The composition of claim 36, wherein said cells comprise a mixture of at least two cell types.

48. The composition of claim 36, further comprising a drug.

49. The composition of claim 48, wherein said drug is a growth factor.

50. The composition of claim 48, wherein said drug is an antibiotic.

51. The composition of claim 1, wherein said activating agent is a carbodiimide.

52. The composition of claim 2, wherein said activating agent is a carbodiimide.