Pseudospontaneous neural stimulation system and method
First Claim
1. A method for generating pseudospontaneous activity in an auditory nerve, comprising:
- generating an electrical signal;
modifying the electrical signal to a sustained effective level while the electrical signal remains substantially physiologically imperceptible to the patient; and
applying the electrical signal to the auditory nerve to generate pseudospontaneous activity in the auditory nerve.
2 Assignments
0 Petitions
Accused Products
Abstract
A system and method for application of pseudospontaneous neural stimulation is provided that can generate stochastic independent activity across an excited nerve or neural population without an additional disadvantageous sensations. High rate pulse trains, for example, can produce random spike patterns in auditory nerve fibers that are statistically similar to those produced by spontaneous activity in the normal ear. This activity is called “pseudospontaneous activity”. Varying rates of pseudospontaneous activity can be created by varying the intensity of a fixed amplitude, high rate pulse train stimulus, e.g., 5000 pps. The pseudospontaneous activity can further desynchronize the nerve fiber population as a treatment for tinnitus but if indiscriminately applied can generate potentially uncomfortable biological and somatosensory sensations over intervals of time. A method for generating pseudospontaneous activity in an auditory nerve according to the present invention can include generating an electrical signal, and modifying the electrical signal to a sustained effective level while the electrical signal remains substantially physiologically imperceptible to the patient. The applied electrical signal can generate pseudospontaneous activity in the auditory nerve to suppress tinnitus.
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Citations
22 Claims
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1. A method for generating pseudospontaneous activity in an auditory nerve, comprising:
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generating an electrical signal;
modifying the electrical signal to a sustained effective level while the electrical signal remains substantially physiologically imperceptible to the patient; and
applying the electrical signal to the auditory nerve to generate pseudospontaneous activity in the auditory nerve. - View Dependent Claims (2, 3, 4)
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5. A neural prosthetic apparatus for treatment of a patient with tinnitus, comprising:
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an adaptor circuit that modifies an electrical signal to a sustained effective level while the electrical signal remains substantially physiologically imperceptible to the patient, wherein the electrical signal is capable of inducing pseudospontaneous activity in an auditory nerve;
an arrangement of at least one electrical contact adapted to be affixed within the cochlea of the patient; and
electrical coupling means for electrically coupling the at least one electrical contact to the adaptor circuit, and wherein the neural prosthetic apparatus effectively alleviates the tinnitus of the patient. - View Dependent Claims (6)
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7. A neural prosthetic apparatus for treatment of a patient with tinnitus, comprising:
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an adaptor that modifies a pseudospontaneous signal to a sustained effective level while the pseudospontaneous signal remains substantially physiologically imperceptible to the patient;
an arrangement of at least one electrical contact adapted to be affixed nearby the cochlea of the patient; and
a stimulation device coupled to the adaptor that applies the electrical signal to the at least one electrical contact, the electrical signal capable of generating pseudospontaneous activity in an auditory nerve, and wherein the neural prosthetic apparatus effectively alleviates the tinnitus of the patient. - View Dependent Claims (8)
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9. A method of identifying an operating range for a neural prosthetic apparatus, comprising:
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generating a pseudospontaneous electrical signal; and
determining the parameters for ramping the pseudospontaneous electrical signal from a first voltage level to a second voltage level, wherein the pseudospontaneous electrical signal applied to an auditory nerve of a patient at the second voltage level effectively generates pseudospontaneous activity in the auditory nerve, and wherein the parameters maintain the pseudospontaneous electrical signal at an approximate level below which pain is perceived by the patient.
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10. A method of identifying an operating modality of a neural prosthetic apparatus for a patient, comprising:
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generating a pseudospontaneous electrical signal;
determining a first voltage level at which the pseudospontaneous electrical signal is not detectable by the patient when applied by the neural prosthetic apparatus;
determining a second voltage level at which the pseudospontaneous electrical signal suppresses tinnitus in the patient when applied by the neural prosthetic apparatus;
determining a time interval of an audible sensory response to the onset of the pseudospontaneous electrical signal at the second level; and
determining a transition sequence for modifying the pseudospontaneous electrical signal from the first voltage level to the second voltage level over a time period not less than the time interval so that the pseudospontaneous electrical signal applied at the second level is substantially imperceptible to the patient. - View Dependent Claims (11, 12)
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13. A method for applying a high frequency signal to a nerve, comprising:
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identifying a voltage level of high frequency signal that is sufficient to cause desired activity in the nerve, wherein the high frequency signal applied at said voltage level further is perceived as pain;
modifying the high frequency signal to be the sufficient voltage level while the electrical signal remains substantially physiologically imperceptible to the patient; and
applying the electrical signal to the nerve to generate pseudospontaneous activity in the nerve. - View Dependent Claims (14, 15)
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16. An apparatus that applies a high frequency signal to a nerve of a patient, wherein a power level of the high frequency signal that is sufficient to cause desired activity in the nerve is perceived as pain to the patient, the apparatus comprising:
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an adaptor circuit that receives and modifies the high frequency signal having transitions between first and second amplitudes occurring at a frequency greater than approximately 2 kHz to a sustained sufficient power level over a time interval, wherein the high frequency signal remains substantially physiologically imperceptible to the patient;
an electrical contact adapted to be affixed to the nerve of the patient; and
a coupler that electrically couples the electrical contact to the adaptor circuit, and wherein the applied high frequency signal after the time interval causes the desired activity.
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17. A method of modifying a neural prosthetic apparatus, comprising:
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providing an adaptor circuit that modifies one or more electrical signals to a sustained effective level while the one or more electrical signals remain substantially physiologically imperceptible to the patient; and
providing an electrical coupling means for supporting an electrical connection from the adaptor circuit to at least one electrical contact, and wherein the one or more electrical signals are capable of inducing a random pattern of activation in an auditory nerve mimicking the spontaneous neural activity of the auditory nerve. - View Dependent Claims (18, 19)
a first voltage level at which the electrical signals are below a detectable level;
a second voltage level at which the electrical signals are above the detectable level and generates the random pattern of activation at a prescribed level;
a time interval of an audible sensory response to the onset of the electrical signals at the second level;
a transition sequence for modifying the electrical signals from the first voltage level to the second voltage level over a time period not less than the time interval.
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20. A method of modifying a neural prosthetic apparatus to generate pseudospontaneous activity in an auditory nerve, comprising:
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providing a pseudospontaneous signal generator that generates an electrical signal capable of inducing the pseudospontaneous activity; and
providing a pattern of application of the electrical signal to the neural prosthetic apparatus that transitions the electrical signal to a sustained effective level from a first level that is below a detection threshold, wherein the pattern of application is capable of keeping the electrical signal substantially physiologically imperceptible to a patient. - View Dependent Claims (21, 22)
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Specification