Antimicrobial fabric and medical graft of the fabric
First Claim
1. A porous, flexible, medical graft comprising:
- (a) fabric material in a generally tubular shape; and
(b) ceramic particles bound to the fabric material, the particles comprising antimicrobial metal cations ion-exchanged thereon, wherein some or all of the ceramic particles are exteriorly exposed to permit entry into the particles of water and cations, thereby effecting an ion exchange reaction, which releases antibiotic cations from the ceramic particles in an antimicrobially effective amount.
10 Assignments
0 Petitions
Accused Products
Abstract
A medical graft, such as a vascular graft, made of a fabric containing an inorganic antimicrobial agent. The fabric has a coating material with the inorganic antimicrobial agent bonded to it, the agent preferably being a zeolite. The fabric can be porous so as to permit tissue to grow on it with the fabric pores providing attachment sites for the tissue. Alternatively, the fabric can be coated with a tissue biocompatible material, such as collagen. A porous fabric applicable for the graft, and for other medical uses, and a method of manufacturing the porous fabric having a coating thereon to which is bonded an antimicrobial agent, such as a zeolite, also is provided. The fabric is antimicrobial, remains pliable, and is also porous.
-
Citations
29 Claims
-
1. A porous, flexible, medical graft comprising:
-
(a) fabric material in a generally tubular shape; and
(b) ceramic particles bound to the fabric material, the particles comprising antimicrobial metal cations ion-exchanged thereon, wherein some or all of the ceramic particles are exteriorly exposed to permit entry into the particles of water and cations, thereby effecting an ion exchange reaction, which releases antibiotic cations from the ceramic particles in an antimicrobially effective amount. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method of making a medical graft comprising:
-
(a) providing porous fabric treated with ceramic particles bound to the fabric material, the particles comprising antimicrobial metal cations ion-exchanged thereon, wherein the process results in some or all of the ceramic particles being exteriorly exposed to permit entry of water and cations into the ceramic particles, thereby effecting an ion exchange reaction, which releases antibiotic cations from the ceramic particles in an antimicrobially effective amount; and
(b) forming said fabric piece into a generally tubular shape to form said graft with said antibiotic agent. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
-
-
18. A method of producing a porous, pliable antimicrobial fabric comprising:
-
(a) providing a porous fabric; and
(b) applying to said fabric ceramic particles while leaving pores of said fabric open, wherein;
(i) the ceramic particles bound to the fabric comprise antimicrobial metal cations ion-exchanged thereon; and
(ii) some or all of the ceramic particles are exteriorly exposed to permit entry of water and cations into the ceramic particles, thereby effecting an ion exchange reaction, which releases antibiotic cations from the ceramic particles in an antibiotically effective amount. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
-
- 26. A pliable antimicrobial fabric comprising a porous fabric comprising an antimicrobial metal ion-generating inorganic antimicrobial agent on fibers of the fabric, with the pores of the fabric left open.
-
28. A porous, flexible medical graft comprising fabric material formed in a generally tubular shape, wherein at least a portion of the fabric material is coated with a polymeric coating material incorporating inorganic ceramic particles, such that some or all of the ceramic particles are exteriorly exposed to release antibiotic metal cations in an antimicrobially effective amount when the medical graft is implanted in vivo.
-
29. A non-porous medical graft, the graft comprising fabric material formed in a generally tubular shape, wherein:
-
(a) the fabric material comprises a first coating comprising a polymeric coating material incorporating inorganic ceramic particles; and
(b) the fabric comprises a second coating comprising a tissue growth-promoting material;
such that some or all of the ceramic particles are exteriorly exposed to release antibiotic metal cations in an antimicrobially effective amount when the medical graft is implanted in vivo.
-
Specification