Method and device for measuring the absorption of radiation in a portion of tissue
First Claim
1. A method for measuring the intensity of light transmitted through a portion of living tissue carrying arterial blood comprising the steps of:
- providing at least two spaced sensor areas, at least one of which is a radiation emitter and at least one of which is a radiation receiver, and invasively introducing at least one sensor area into said living tissue in a manner whereby a portion of said living tissue is between the sensor areas for its transillumination, wherein the radiation emitter emits at least a first and a second wavelength which are received by the radiation receiver; and
further including a step of selecting the wavelengths of the radiation in order to determine a hemoglobin fraction.
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Accused Products
Abstract
Device and method for measuring the absorption of radiation in a portion of tissue. For monitoring tissue and/or in order to permit medical indications, it is necessary to gather parameters allowing an assessement of the condition of the tissue, especially with regard to its oxygen supply. The disclosed invention provides a sensor carrier (1) at the loose end of which a sensor device (2) is mounted. This sensor device carries sensor areas (5, 6) which are connected to a measuring instrument (4). Light is emitted from a sensor area (5) and received by a sensor (6) after having transilluminated the tissue. The disclosed invention may be used for examining and controlling the tissue, for example, for perinatal measurement of arterial oxygen saturation of the fetus.
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Citations
32 Claims
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1. A method for measuring the intensity of light transmitted through a portion of living tissue carrying arterial blood comprising the steps of:
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providing at least two spaced sensor areas, at least one of which is a radiation emitter and at least one of which is a radiation receiver, and invasively introducing at least one sensor area into said living tissue in a manner whereby a portion of said living tissue is between the sensor areas for its transillumination, wherein the radiation emitter emits at least a first and a second wavelength which are received by the radiation receiver; and
further including a step of selecting the wavelengths of the radiation in order to determine a hemoglobin fraction.- View Dependent Claims (2)
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3. A device for use in measuring radiation transmitted through a portion of living tissue comprising:
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at least two spaced sensor areas, with one of the sensor areas being constructed as a radiation emitter and the other sensor area being constructed as a radiation receiver for receiving radiation from the radiation emitter after transillumination of living tissue located between the sensor areas, and an evaluation unit, the sensor areas coupled to said evaluation unit, wherein at least one of the sensor areas further comprises a tissue penetrating carrier, and wherein the tissue penetrating carrier is in the form of a spiral for screwing into the tissue. - View Dependent Claims (4, 5, 6, 7)
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8. A device for use in measuring radiation transmitted through a portion of living tissue comprising:
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at least two spaced sensor areas, one of the sensor areas being constructed as a radiation emitter for transilluminating living tissue located between the sensors areas, and the other senior area being constructed as a radiation sensor for sensing radiation from the radiation emitter;
a measuring instrument, the sensor areas coupled to said measuring instrument, wherein at least one of the sensors areas further cover a tissue penetrating carrier; and
means coupled to the radiation sensor for collecting information from the radiation sensor and for providing additional parameters including, at least, ECG.
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9. A method of in vivo measuring radiation transmitted through a portion of living tissue comprising the steps of:
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providing a sensor device having at least two spaced sensor area, at least one of said two sensor areas comprising at least one optical fiber, said optical fiber being housed within a sensor carrier formed as a hollow spiral and terminating with a point, at least one of the sensor areas constituting the radiation emitter and at least one of the other of the sensor areas constituting the radiation receiver;
screwing maid spiral sensor carrier with said optical fiber into said tissue whereby said carrier point and an end of said optical fiber enters said tissue to be transilluminated;
analyzing radiation within the spectral range of between 0.1 μ
m and 20 μ
m, originating from said radiation emitter, and transmitted through the tissue, to transilluminate said tissue between said two sensor areas; and
sensing maid transmitted radiation reaching said receiver.
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10. A perinatal sensing system for determining the oxygen saturation of blood by the transillumination of living tissue, wherein light transmission in selected spectral ranges changes in intensity in response to different levels of oxygen saturation, comprising:
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means for generating light at an interstitial subcutaneous location within said tissue such that said generated light is transmitted to an epidermal location; and
means for detecting changes in intensity of said light transmitted through to said epidermal location to determine an oxygen maturation within said tissue.
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11. A perinatal sensing system for determining blood oxygen saturation by transillumination of living tissue, wherein the intensity of light transmitted in select spectral regions changes in response to different levels of blood oxygenation, comprising;
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means for generating light upon an epidermal location such that said generated light is transmitted to an interstitial subcutaneous location; and
means at said interstitial subcutaneous location for detecting changes in intensity of said transmitted light in order to determine an oxygen saturation within said tissue.
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12. A perinatal sensing system for determining blood oxygen saturation within body living tissue by transillumination wherein the light transmission changes in intensity in response to different levels of oxygen saturation, comprising:
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means for generating light at a first interstitial subcutaneous location within said tissue; and
means for receiving light at a second interstitial subcutaneous location within said tissue in order to detect the changes in intensity of said light transmitted through said living tissue between said first and said second interstitial location in order to determine a the oxygen saturation of the blood.
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13. A method for measuring the intensity of light transmitted through a portion of living tissue carrying arterial blood comprising the steps of:
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providing at least two spaced sensor areas, at least one of which is a radiation emitter and at least one of which is a radiation receiver, on a single-piece sensor carrier, invasively introducing at least one sensor area into said living tissue in a manner whereby a portion of said living tissue is between the sensor areas for its transillumination, emitting radiation from said radiation emitter, and measuring the amount of radiation absorbed between said emitter and receiver. - View Dependent Claims (14)
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15. A method for measuring the intensity of light transmitted through a portion of living tissue carrying arterial blood comprising the steps of providing at least two spaced sensor areas, at least one of which is a radiation emitter and at least one of which is a radiation receiver, and invasively introducing at least one sensor area into said living tissue in a manner whereby a portion of said living tissue is between the sensor areas for its transillumination, wherein the radiation emitter emits at least a first and a second spectral range which are received by the radiation receiver, wherein oxygen saturation is a function of both the pulsatile and the steady light absorption in said first and second spectral ranges, and wherein said first spectral range is adapted to measuring the total hemoglobin level and said second spectral range is adapted to measuring oxyhemoglobin.
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16. A method for measuring the intensity of light transmitted through a portion of living tissue carrying arterial blood comprising the steps of:
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providing at least two spaced sensor areas, at least one of which is a radiation emitter and at least one of which in a radiation receiver, invasively introducing at least one sensor area into said living tissue in a manner whereby a portion of said living tissue is between the Bangor areas for its transillumination, wherein said radiation receiver generates an electric signal which is, for each of said spectral ranges, proportional to the total transilluminated light within a spectral range, which signals comprises a constant, non-pulsatile signal component and a pulsatile signal component, performing calculations on the basis of said constant and said pulsatile Signals relative to said constant, non-pulsatile signal components of each spectral range from the total transilluminated signal, and generating from said calculations a value which is a function of the open saturation of the arterial blood.
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17. A device for use in measuring radiation transmitted through a portion of living tissue comprising at least two spaced sensor areas, with one of the sensor areas being constructed as a radiation emitter and the other sensor area being constructed as a radiation receiver for sensing radiation transilluminated through living tissue from the radiation emitter, and
a measuring instrument, the sensor areas coupled to said measuring instrument, wherein at least one of the sensor areas further comprises a tissue penetrating carrier, wherein one of said sensor areas is positionable in living tissue and is an electro-optical converter.
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19. A perinatal sensing system for determining blood oxygenation within a body comprising:
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means for generating light at an interstitial subcutaneous location within a body;
means for transmitting said generated light from said subcutaneous location to an epidermal location of a body, and means for detecting changes in intensity of said light transmitted through the tissue to said epidermal location wherein the transmitted light passing through the body changes in intensity in response to different levels of blood oxygenation;
in order to determine blood oxygenation within said body.
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20. A method for measuring the intensity of light transmitted through a portion of living tissue carrying arterial blood comprising the steps of:
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selecting spectral ranges of radiation to be used to determine hemoglobin fractions in interest, providing at least two spaced sensor areas, at least one of which is a radiation emitter and at least one of which is a radiation receiver, wherein said radiation emitter sensor area emits at least a first and a second spectral range that are received by said radiation receiver, disposing at least one sensor area within said living tissue such that a portion of said living tissue is between said sensor areas for its transillumination, wherein said radiation receiver generates signals proportional to the light intensities received after transillumination of said living tissue in said respective spectral ranges, the signals comprising for each spectral range a constant, non-pulsatile signal component and a pulsatile signal component, and performing calculations on the basis of said constant and said pulsatile signal components of each of said spectral ranges to determine a value which is a function of the oxygen saturation of the arterial blood. - View Dependent Claims (21)
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- 22. A device for use in measuring radiation transmitted through a portion of living tissue, said device comprising a sensor carrier carrying two sensor areas, one of which is a radiation emitter and the other of which is a radiation receiver, said sensor carrier adapted for introducing at least one of said sensor areas into an interstitial subcutaneous location within a body, said radiation emitter transmitting light at a spectral range which changes in intensity in response to different levels of blood oxygenation saturation when passing in arteries and arterioles through said living tissue, said radiation receiver sensing said changes in intensity of said transmitted light.
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31. A method of in vivo measuring radiation transmitted through a portion of living tissue comprising the steps of:
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providing a sensor device having at least two spaced sensor areas, at least one of said two sensor areas comprising at least one semiconductor, said semiconductor being housed within a sensor carrier formed as a hollow spiral and terminating with a point, at least one of the sensor areas constituting a radiation emitter and at least one of the other of the sensor areas constituting a radiation receiver;
screwing said hollow spiral type sensor carrier with said semiconductor into said tissue whereby the point and an end of said semiconductor enters said tissue to be transilluminated;
analyzing the radiation, in a spectral range between 0.1 μ
m and 20 μ
m, originating from the radiation emitter, transmitted through the tissue, to transilluminate said tissue between said two sensor areas; and
sensing said transmitted radiation reaching the receiver.
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32. A method for determining the concentration of a substance in pulsating blood, the method comprising the steps of:
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providing at least two spaced sensor areas, at least one of which is a radiation emitter for emitting radiation, and at least one of which is a radiation sensor for receiving radiation;
invasively introducing at least one sensor area into living tissue carrying said pulsating blood such that a portion of said living tissue is between said spaced sensor areas; and
emitting radiation from said radiation emitter and measuring the amount of radiation absorbed between said emitter and receiver;
wherein the radiation emitter and the radiation sensor are provided on separate carriers;
wherein the concentration of said substance influences the intensity of radiation received by the radiation sensor; and
calculating the concentration of the substance in pulsating blood based on the measurement amount of radiation.
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Specification