Cardiac output controller

• US 6,298,268 B1
• Filed: 03/12/1999
• Issued: 10/02/2001
• Est. Priority Date: 09/16/1996
• Status: Expired due to Term

• Current Assignee: Impulse Dynamics NV
• Original Assignee: Impulse Dynamics NV
• Inventors: Ben-Haim, Shlomo, Darvish, Nissim, Mika, Yuval, Fenster, Maier
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/254,902
• Time in Patent Office: 935 Days
• Field of Search: 607/4, 607/5, 607/9, 607/11, 607/68
• US Class Current: 607/9
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/0243 for immobilizing local areas of the heart, e.g. while it beats
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/3655 controlled by body or blood temperature
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

This invention is an apparatus for modifying cardiac output of the heart of a subject, including one or more sensors which sense signals responsive to cardiac activity, and a stimulation probe including one or more stimulation electrodes which apply non-excitatory stimulation pulses to a cardiac muscle segment. Signal generation circuitry is coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses responsive to the signals.

Claims

1. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates non-excitatory stimulation pulses, only at a time at which they are unable to propagate action potentials responsive to the signals,

wherein the signal generation circuitry identifies an arrhythmia in the signals and controls the stimulation pulses responsive thereto.

2. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the signal generation circuitry detects a QT interval in the signals and controls the stimulation pulses responsive thereto.

3. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the one or more stimulation electrodes apply the stimulation pulse to a heart segment having an area of at least 1 cm².

4. Apparatus according to claim 3, wherein the one or more stimulation electrodes apply the stimulation pulse to a heart segment having an area of at least 4 cm².

5. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the one or more stimulation electrodes apply the stimulation pulse to a heart segment having an area of at least 5 mm², and wherein the signal generation circuitry varies the area of the heart segment to which the stimulation pulse is applied.

6. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates non-excitatory stimulation pulses, only at a time at which they are unable to propagate action potentials responsive to the signals,

wherein the stimulation probes comprises a net of electrodes.

7. Apparatus according to claim 6, wherein the electrodes in the net are addressable, such that an extent of the segment to which the stimulation pulses is applied is controlled by addressing selected electrodes in the net.

8. Apparatus according to claim 6, wherein the circuitry applies multiple, different stimulation pulses to different ones of the electrodes in the net.

9. Apparatus according to claim 8, wherein the multiple, different stimulation pulses comprises a time sequence of pulses.

20. A method according to claim 8, wherein the waveform comprises a square wave.

21. A method according to claim 8, wherein varying the extent comprises selectively addressing a net of stimulation electrodes implanted in the heart.

10. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the one or more sensors comprise an intracardiac electrode, and wherein the signal generation circuitry synchronizes the stimulation pulse to electrical activity of the heart, and wherein the stimulation probe comprises a hybrid electrode, including the intracardiac electrode together with at least one of the one or more stimulation electrodes.

11. Apparatus according to claim 10, wherein the hybrid electrode comprises a core section including the sensing electrode, enclosed within an annular section including the at least one stimulation electrode.

12. Apparatus according, to claim 11, wherein the annular section comprises a carbon material.

13. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the one or more sensors comprise a hemodynamic sensor, which generates signals responsive to blood flow.

14. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the one or more sensors comprise a hemodynamic sensor, which generates signals responsive to blood oxygenation.

15. Apparatus for modifying cardiac output of the heart of a subject, comprising:

one or more sensors, which sense signals responsive to cardiac activity;

a stimulation probe comprising one or more stimulation electrodes, which apply non-excitatory stimulation pulses to a cardiac muscle segment; and

signal generation circuitry, coupled to the one or more sensors and the stimulation probe, which circuitry receives the signals from the one or more sensors and generates the non-excitatory stimulation pulses, responsive to the signals,

wherein the one or more sensors comprise a hemodynamic sensor, which generates signals responsive to a temperature.

16. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein applying the stimulation probe comprises applying a probe comprising a plurality of stimulation electrodes, and wherein generating and conveying the pulse comprises generating a sequence of pulses and applying each pulse in the sequence to a different one of the plurality of stimulation electrodes.

17. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse only at a time at which it is unable to propagate action potentials responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein generating and conveying the pulse comprises detecting a cardiac arrhythmia and adjusting the application of the pulses responsive thereto.

18. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein generating and conveying the pulse comprises detecting a QT interval in the signals and generating pulses responsive thereto.

19. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein the pulse comprises a baseline pulse and a waveform of substantially higher frequency than the baseline pulse superimposed thereon.

22. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein applying the stimulation probe comprises varying the extent of a portion of the area of the heart segment to which the stimulation pulse is applied.

23. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein applying the stimulation probe comprises inserting at least one of the one or more stimulation electrodes into the coronary sinus.

24. A method according to claim 23, wherein inserting the at least one stimulation electrode comprises inserting the electrode into the coronary sinus.

25. A method according to claim 23, wherein sensing the hemodynamic parameter comprises sensing cardiac output, and wherein generating the pulse comprises changing the pulse responsive to the signal to increase the cardiac output.

26. A method according to claim 23, wherein sensing the hemodynamic parameter comprises sensing cardiac output, and wherein generating the pulse comprises changing the pulse responsive to the signal to decrease the cardiac output.

27. A method according to claim 23, wherein sensing the hemodynamic parameter comprises sensing a pressure.

28. A method according to claim 23, wherein sensing the hemodynamic parameter comprises sensing a flow rate.

29. A method according to claim 23, wherein sensing the hemodynamic parameter comprises sensing oxygenation.

30. A method according to claim 23, wherein sensing the hemodynamic parameter comprises sensing a temperature.

31. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein receiving the signal comprises sensing cardiac output, and wherein generating the pulse comprises changing the pulse responsive to the signal to increase the cardiac output.

32. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein receiving the signal comprises sensing cardiac output, and wherein generating the pulse comprises changing the pulse responsive to the signal to decrease the cardiac output.

33. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein receiving the signal comprises sensing a pressure.

34. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein receiving the signal comprises sensing a flow rate.

35. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein receiving the signal comprises sensing oxygenation.

36. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein receiving the signal comprises sensing a temperature.

37. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein generating and conveying the pulse comprises generating and conveying pulses at selected times of day.

38. A method according to claim 37, wherein generating and conveying the pulse comprises generating and conveying pulses at selected times of day.

39. A method according to claim 38, wherein generating and conveying the pulses at selected times of day comprises conveying pulses to increase cardiac output during the subject'"'"'s waking hours.

40. A method for modifying cardiac output, comprising:

applying a stimulation probe comprising one or more stimulation electrodes to a subject'"'"'s heart;

receiving a signal from at least one sensor responsive to the subject'"'"'s cardiac muscle activity; and

generating a non-excitatory stimulation pulse responsive to the signal and conveying the pulse to at least one of the one or more electrodes,

wherein conveying the pulses comprises applying pulses to a heart segment having an area of at least 1 cm².

41. A method according to claim 40, wherein applying the pulses comprises applying pulses to a heart segment having an area of at least 1 cm².

42. A method according to claim 41, wherein applying the pulses comprises applying pulses to a heart segment having an area of at least 4 cm².