Coated implantable medical device
First Claim
1. An implantable medical device (10), comprising:
- a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being composed of a base material (14);
at least one coating layer (16) posited on one surface of the structure (12); and
at least one layer (18) of a first bioactive material posited over at least a portion of the at least one coating layer (16), wherein said at least one coating layer (16) provides for a controlled release of the bioactive material from the at least one coating layer (16), and wherein said first bioactive material (18) comprises paclitaxel and has cytotoxic properties.
4 Assignments
0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
-
Citations
26 Claims
-
1. An implantable medical device (10), comprising:
-
a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being composed of a base material (14);
at least one coating layer (16) posited on one surface of the structure (12); and
at least one layer (18) of a first bioactive material posited over at least a portion of the at least one coating layer (16), wherein said at least one coating layer (16) provides for a controlled release of the bioactive material from the at least one coating layer (16), and wherein said first bioactive material (18) comprises paclitaxel and has cytotoxic properties. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. An implantable medical device (10), comprising:
-
a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being comprised of a base material (14); and
at least one layer (18) of a bioactive material having cytotoxic properties posited on the at least one surface of the structure (12), wherein said bioactive material (18) comprises paclitaxel. - View Dependent Claims (19, 20, 21, 22, 23, 24)
-
-
25. An implantable medical deice (10), comprising:
-
a structure (12) adapted for introduction into a patient, the structure (12) having at least one surface and being composed of a base material (14);
at least one adhesion promotion layer (30) posited on one surface of the structure (12); and
at least one layer (18) of a first bioactive material having cytotoxic properties posited over at least a portion of the at least one adhesion promotion layer (30), wherein said first bioactive material (18) comprises paclitaxel. - View Dependent Claims (26)
-
Specification