Water-soluble coating for bioactive vasoocclusive devices

• US 6,299,627 B1
• Filed: 10/08/1999
• Issued: 10/09/2001
• Est. Priority Date: 06/18/1998
• Status: Expired due to Term

• Current Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Original Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Inventors: Olsen, Stanley W. Jr., Abrams, Robert M, Eder, Joseph C., Slaikeu, Paul C.
• Primary Examiner(s): Recla, Henry J.
• Assistant Examiner(s): HO, TAN-UYEN THI
• Application Number:
  US09/414,616
• Time in Patent Office: 732 Days
• Field of Search: 606/190, 606/191, 606/192, 606/207, 606/108, 623/1
• US Class Current: 606/191
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated

Abstract

A vaso-occlusive device having an inner coating and a water-soluble outer coating. Methods of preparing the devices are also provided.

Claims

1. A vaso-occlusive device comprising:

a) a vaso-occlusive member;

b) an inner coating on said vaso-occlusive member; and

c) an outer coating on said inner coating, said outer coating comprising a water-soluble agent and a hydrophilic component that affects the solubility of said outer coating.

2. The device of claim 1, wherein the vaso-occlusive member is a metallic element comprising an elongated helical coil.

3. The device of claim 2 wherein the coil is a cylindrical helical coil.

4. The device of claim 2 wherein the coil comprises a metal selected from gold, rhenium, platinum, palladium, rhodium, ruthenium, stainless steel, tungsten and alloys thereof.

5. The device of claim 1 wherein the inner coating is permanently bonded to said vaso-occlusive member.

6. The device of claim 1 wherein the inner coating is created by plasma treatment.

7. The device of claim 1 wherein said outer coating is a water-soluble anti-thrombogenic agent.

8. The device of claim 1 wherein the outer coating is selected from the group consisting of acetyl salicylic acid, heparin, coumadin and alnert.

9. The device of claim 1 wherein said hydrophilic component is incorporated in the outer coating.

10. The device of claim 1 wherein said hydrophilic component is added as an overcoating on said outer coating.

11. The device of claim 1 wherein the water-soluble agent dissolves shortly after said vaso-occlusive member is deployed.

12. The device of claim 1 wherein the inner and outer coatings do not affect the shape of said vaso-occlusive member after deployment.

13. An implantable device for use in medical applications comprising:

a) a support member;

b) an inner coating on said support member; and

c) an outer coating on said inner coating, said outer coating comprising a water-soluble agent and a lipid compound that affects the solubility of said outer coating.