Percutaneous biofixed medical implants

• US 6,299,930 B1
• Filed: 09/20/1999
• Issued: 10/09/2001
• Est. Priority Date: 10/10/1997
• Status: Expired due to Fees

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida), Usbiomaterials Corporation
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida), Usbiomaterials Corporation
• Inventors: Marotta, James S., Hench, Larry L., Batich, Christopher, LaTorre, Guy
• Primary Examiner(s): Nguyen, Dinh X.
• Application Number:
  US09/400,657
• Time in Patent Office: 750 Days
• Field of Search: 623/11.11, 623/16.11, 623/23.5, 623/23.51, 623/23.57, 623/23.6, 623/23.72, 623/23.73, 623/23.74, 623/23.75, 623/23.76, 427/2.28, 427/2.1, 427/2.31
• US Class Current: 427/2.28
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61F 2310/00796 Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
• CPC Class Codes: A61F 2310/00928 Coating or prosthesis-covering structure made of glass or of glass-containing compounds, e.g. of bioglass
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61M 2039/0261 Means for anchoring port to the body, or ports having a special shape or being made of a specific material to allow easy implantation/integration in the body
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053

Abstract

Percutaneous implants are disclosed including a portion implantable into a patient, a dermal bonding region capable of forming a bond between the implant and a dermal layer of the patient after the implantable portion is implanted into the patient, and the dermal bonding region including a substrate with a discontinuous coating of particulate bioactive glass wherein the average spacing between the particles of bioactive glass is predetermined and at least about 20 microns prior to implantation into the patient. Also disclosed are bioactive coatings including a substrate and fibers and/or particles of bioactive glass distributed on the substrate with a predetermined average interfiber distance of at least about 20 microns.

Claims

1. A bioactive coating comprising a substrate and particles of bioactive glass distributed on the substrate with a predetermined average interparticle distance of at least about 20 microns.

2. The bioactive coating of claim 1, wherein said particles have an average spacing of at least about 40 microns.

3. The bioactive coating of claim 1, wherein said particles have an average spacing of at least about 60 microns.

4. The bioactive coating of claim 1, wherein said particles have an average spacing of at least about 80 microns.

5. The bioactive coating of claim 1, wherein said particles have an average spacing of at least about 100 microns.

6. The bioactive coating of claim 1, wherein said particles have an average spacing of at least about 150 microns.

7. The bioactive coating of claim 1, wherein said particles have an average spacing of at least about 200 microns.

8. The coating of claim 1, wherein the substrate is silicone or a modified silicone polymer.

9. A bioactive tape comprising a tape substrate and the coating of claim 1.

10. A bioactive coating comprising a substrate and fibers of bioactive glass distributed on the substrate with a predetermined average interfiber distance of at least about 20 microns.