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DNA diagnostics based on mass spectrometry

DC
  • US 6,300,076 B1
  • Filed: 01/31/2000
  • Issued: 10/09/2001
  • Est. Priority Date: 03/17/1995
  • Status: Expired due to Term
First Claim
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1. A process for detecting one or more target nucleic acid sequences in a biological sample, comprising:

  • a) amplifying one or more nucleic acid molecules;

    b) ionizing and volatilizing the product of step a); and

    c) analyzing the ionized and volatilized nucleic acid molecules by mass spectrometry, whereby detection of the target nucleic acid sequence by mass spectrometry indicates the presence of the target nucleic acid sequence in the biological sample.

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