DNA diagnostics based on mass spectrometry
DCFirst Claim
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1. A process for detecting one or more target nucleic acid sequences in a biological sample, comprising:
- a) amplifying one or more nucleic acid molecules;
b) ionizing and volatilizing the product of step a); and
c) analyzing the ionized and volatilized nucleic acid molecules by mass spectrometry, whereby detection of the target nucleic acid sequence by mass spectrometry indicates the presence of the target nucleic acid sequence in the biological sample.
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Abstract
Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogen, or for determining identity or heredity.
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Citations
18 Claims
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1. A process for detecting one or more target nucleic acid sequences in a biological sample, comprising:
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a) amplifying one or more nucleic acid molecules;
b) ionizing and volatilizing the product of step a); and
c) analyzing the ionized and volatilized nucleic acid molecules by mass spectrometry, whereby detection of the target nucleic acid sequence by mass spectrometry indicates the presence of the target nucleic acid sequence in the biological sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 17)
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9. A process for detecting one or more target nucleic acids in a biological sample, comprising:
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a) analyzing nucleic acids from the sample by mass spectrometry; and
b) detecting the target nucleic acid by a specific molecular weight. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 18)
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Specification