Antisense inhibition of telomeric repeat binding factor 2 expression
First Claim
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1. An antisense compound 8 to 30 nucleobases in length targeted to regions of a nucleic acid encoding a 5′
- -UTR, a through 1809 or nucleotides 1839 through 1913 or nucleotides 2007 through 2413 of a 3′
-UTR of human Telomeric repeat binding factor 2, wherein said antisense compound specifically hybridizes with said regions of a nucleic acid molecule encoding human Telomeric repeat binding factor 2 and inhibits the expression of human Telomeric repeat binding factor 2.
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric repeat binding factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Telomeric repeat binding factor 2. Methods of using these compounds for modulation of Telomeric repeat binding factor 2 expression and for treatment of diseases associated with expression of Telomeric repeat binding factor 2 are provided.
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Citations
26 Claims
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1. An antisense compound 8 to 30 nucleobases in length targeted to regions of a nucleic acid encoding a 5′
- -UTR, a through 1809 or nucleotides 1839 through 1913 or nucleotides 2007 through 2413 of a 3′
-UTR of human Telomeric repeat binding factor 2, wherein said antisense compound specifically hybridizes with said regions of a nucleic acid molecule encoding human Telomeric repeat binding factor 2 and inhibits the expression of human Telomeric repeat binding factor 2. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- -UTR, a through 1809 or nucleotides 1839 through 1913 or nucleotides 2007 through 2413 of a 3′
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3. An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 43, 45, 46, 48, 49, 56, 59, 61, 62, 63, 64, 65, 67, 68, 70, 71, 73, 75, 76, 77, 78, 83, 85, 87 or 89 which inhibits expression of human Telomeric repeat binding factor 2.
- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
Specification