Targeted oligonucleotide conjugates
First Claim
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1. A complex comprising:
- a primary moiety for modulating a cellular function;
at least two cell surface receptor ligands; and
a manifold covalently connected to said primary moiety and each of said cell surface receptor ligands;
said manifold being a polycyclic molecule.
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Abstract
The present invention provides improved ingress of therapeutic and other moieties into cellular targets. In accordance with preferred embodiments, complexes are provided which carry primary moieties, chiefly therapeutic moieties, to such target cells. Such complexes preferably feature cell surface receptor ligands to provide specificity. Such ligands are preferably bound to primary moieties through polyfunctional manifold compounds.
180 Citations
25 Claims
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1. A complex comprising:
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a primary moiety for modulating a cellular function;
at least two cell surface receptor ligands; and
a manifold covalently connected to said primary moiety and each of said cell surface receptor ligands;
said manifold being a polycyclic molecule.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A chemical complex having the formula:
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wherein said primary moiety is a nucleotide, nucleoside, oligonucleotide or oligonucleoside;
each of said linkers are, independently, bi- or trifunctional;
said manifold is derivatized at a plurality of sites, said manifold being a polycyclic molecule;
each of said cell surface receptor ligands is a carbohydrate; and
n is an integer from 2 to about 8. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification