Inhibition of tumor necrosis factor alpha

• US 6,300,349 B1
• Filed: 07/30/1999
• Issued: 10/09/2001
• Est. Priority Date: 09/19/1995
• Status: Expired due to Term

• Current Assignee: Intermune Incorporated (Roche Holding AG)
• Original Assignee: Solomon B. Margolin
• Inventors: Margolin, Solomon B.
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US09/364,562
• Time in Patent Office: 802 Days
• Field of Search: 514/345, 514/311, 514/334
• US Class Current: 514/345
• CPC Class Codes: A61K 31/4412 having oxo groups directly attached to the heterocyclic ring
• CPC Class Codes: A61K 31/4418 having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
• CPC Class Codes: A61K 31/4436 containing a heterocyclic ring having sulfur as a ring hetero atom
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 31/444 containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
• CPC Class Codes: A61K 31/4709 Non-condensed quinolines and containing further heterocyclic rings
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

In a preferred embodiment, a method for the inhibition of the synthesis and release of tumor necrosis factor from various cells, comprising: administering to a human or other mammal an effective dose of one or more pharmaceutical substances selected from the group consisting of N-substituted 2(1H) pyridones, N-substituted 3(1H) pyridones, and pharmaceutically acceptable salts thereof.

Claims

1. A method for the inhibition of the synthesis and release of tumor necrosis factor from various cells, comprising:

administering to a human or other mammal, an effective dose of one or more pharmaceutical substances selected from the group consisting of N-substituted 2(1H) pyridones, N-substituted 3(1H) pyridones, and pharmaceutically acceptable salts thereof to treat a condition selected from the group consisting of central nervous system syndromes, such as relapsing-remitting, multiple sclerosis, primary and secondary multiple sclerosis, spinal multiple sclerosis, cerebral malaria, viral or bacterial infections of the central nervous system, bacterial meningitis, “

autoimmune”

disorders of the central nervous system, central nervous system stroke and infarction, brain edema, Parkinson'"'"'s syndrome, amyotrophiic lateral sclerosis, brain concussion or contusion, musculo-skeletal syndrome, such as rheumatoid arthritis, trauma-induced arthritis, arthritis caused by a microbial infection, or by a parasite, tendonitis, arthritis induced by medical products or drugs (including, small synthetic molecules as well as purified natural or synthesized peptides or proteins), pulmonary syndromes, such as acute adult respiratory distress syndrome, asthma, allergic rhinitis, allergic generalized reactions, allergic conjunctivitis, chronic obstructive pulmonary disease, and lung sarcoidosis, systemic immunologic, inflammatory, or toxic syndromes, such as endotoxemia shock syndrome, septic shock, graft-host disease following, bone-marrow transplantation, hemorrhagic shock, reperfusion injury of the brain or myocardium, thermal burns, radiation injury, general or dermal traumatic or contusion injuries, eosinophilic granuloma, diabetes mellitus (Type

     11), and systemic lupus erythromatosus, and gastro-intestinal syndromes, such as Crohn'"'"'s disease, ulcerative colitis, and liver inflammatory disorders.