Method of determining carotid artery stenosis using X-ray imagery

• US 6,301,498 B1
• Filed: 04/16/1999
• Issued: 10/09/2001
• Est. Priority Date: 04/17/1998
• Status: Expired due to Fees

• Current Assignee: Cornell Research Foundation Incorporated (Cornell University)
• Original Assignee: Cornell Research Foundation Incorporated (Cornell University)
• Inventors: Greenberg, Roy K., Celes, Waldemar, Greenberg, Donald
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/293,016
• Time in Patent Office: 907 Days
• Field of Search: 600/425, 600/431
• US Class Current: 600/425
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography

Abstract

A method and apparatus for generating a three-dimensional shape of an artery comprising the step of obtaining at least one angiographic X-ray image of an artery cross section, so that there are lines that define the walls of the artery which have data representing X-ray intensity that can be used to determine artery thickness; gathering the data and inputting that data into a computer; using the data to create a three-dimensional image of the artery.

Claims

1. A method for generating a three-dimensional shape of an artery comprising the steps of:

obtaining a plurality of images at different angles so that each image defines the walls of the artery and comprises data representative of artery thickness;

scanning the images to generate sets of lumen functions representative of thickness of the artery;

iteratively reconstructing the lumen functions to create a three-dimensional image of the artery.

2. The method of claim 1 wherein:

the images are X-ray images; and

the data comprises data defining the walls of the artery.

3. The method of claim 2 wherein:

the X-ray images are angiographic X-ray images.

4. The method of claim 2 wherein:

the step of scanning the images comprises measuring the intensity variation of the X-ray'"'"'s in each image.

5. The method of claim 1 wherein:

the step of iteratively reconstructing further comprises;

obtaining initial guess cross sections of the arteries,

fitting the initial guess cross section into the boundaries of the lumen functions;

adjusting the initial guess cross section in accordance with the lumen functions;

scale the lumen functions in accordance with the adjusted initial guess cross section;

and performing a first iterative reconstruction for each lumen function to generate first iterative reconstructed guess sections selecting and using a first lumen function to reconstruct the initial guess section, so as to perform a first iteration yielding a reconstructed guess section of the first iteration.

6. The method of claim 5 further comprising the steps of:

selecting the first iterative reconstructed guess sections;

performing one or more iterative reconstructions for each lumen functions to generate successive iterations of further reconstructed guess sections.

7. A method for generating a graphic three dimensional image of a portion of an artery comprising the steps of:

capturing four X-ray images of the artery at four angles;

dividing the images into a series of sequential cross-sectional planes spaced one from each other;

for each plane, scanning each of the images to generate a lumen function for each of the four angles,

choosing an initial outline image for each cross-section;

selecting one of the four lumen functions;

upwardly reconstructing a modified outline of the chosen outline image using the selected lumen function;

reconstructing a first set of three lumen functions by comparing the upwardly modified outline to the respective three lumen functions and identifying the differences between the original and the reconstructed lumen functions;

downwardly reconstructing a second modified outline of the chosen outline image using the selected lumen function;

reconstructing a second set of three lumen functions by comparing the upwardly modified outline to the respective three lumen functions and identifying the differences between the original and the reconstructed lumen functions;

blending the changes to the contours made in the first and second modified outlines to generate a third modified outline;

reconstructing a third set of three lumen functions from the third modified outline by comparing each of the three lumen functions to the third modified outline;

from among the resulting modified outlines, selecting the outline having the least cumulative differences between the reconstructed and original lumen functions; and

aligning the selected images to generate a three dimensional graphic mesh image of the artery.

8. The method of claim 7 further comprising one or more iterations of the reconstructing steps using the selected outlines of the prior iterations.

9. The method of claim 8 further comprising the steps of:

representing the best reconstructed guess section amongst the first, second, third and fourth iterations by non-uniform B splines.

10. The method of claim 9 further comprising the steps of:

obtaining the X-ray images of multiple artery sections located one above each other so that they are stacked;

determining the interpolated mesh of the multiple carotid artery sections located one above each other.

11. An apparatus for determining three-dimensional artery section shape comprising:

a device for obtain an angiographic image of an artery cross section so that there are lines that define the walls of the artery, the lines that define the walls of the artery having data which represent varying degrees of X-ray intensity which correspond to artery thickness;

a means for gathering the data and using the data so that it can be used to determine artery shape so as to create a three-dimensional image of the artery;

a densitometer capable of measuring the X-ray intensity; and

means for expressing the X-ray intensity for each X-ray image as lumen functions across an artery cross section.