Gas chromatographic device

• US 6,301,952 B1
• Filed: 12/24/1999
• Issued: 10/16/2001
• Est. Priority Date: 12/30/1998
• Status: Expired due to Fees

• Current Assignee: Varian B.V. (Agilent Technologies, Inc.)
• Original Assignee: Varian Incorporated (Agilent Technologies, Inc.)
• Inventors: De Zeeuw, Jaap, Peene, Jan Adriaan, de Nijs, Rene Cornelis Maria
• Primary Examiner(s): Larkin, Daniel S.
• Assistant Examiner(s): WIGGINS, JOHN DAVID
• Application Number:
  US09/471,661
• Time in Patent Office: 662 Days
• Field of Search: 73/233.5, 73/233.7, 73/234.1, 73/233.9, 73/234.2, 73/615.5, 73/615.6, 738/642.1, 738/647.2, 738/648.7, 210/656, 210/659
• US Class Current: 73/23.35
• CPC Class Codes: G01N 2030/6008 capillary restrictors
• CPC Class Codes: G01N 2030/7226 OWTC, short capillaries or transfer line used as column
• CPC Class Codes: G01N 30/32 of pressure or speed G01N30/36 takes precedence
• CPC Class Codes: G01N 30/7206 interfaced to gas chromatograph interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04
• CPC Class Codes: H01J 49/00 Particle spectrometers or separator tubes

Abstract

A gas chromatographic device has an inlet system, a column and a pressure reducing means combined and assembled in such a series arrangement that provides adequate system performance with shorter wide bore column length and shorter sample analysis times needed during a peak integration and evaluation process performed by a connected mass spectrometer system. Pressure reducing means may be integral part of the inlet system or the column when positioned between the inlet system and the column. Pressure reducing means preferably positioned before the column and being capable of reducing the pressure prevailing at the inlet of said pressure reducing means to a column outlet pressure which is essentially vacuum. Preferably, the inlet pressure of the device is in a range between 10 kPa and 1000 kPa and the absolute pressure prevailing at the outlet of said pressure reducing means is in a range between 0.00001 kPa and 50 kPa.

Claims

1. A gas chromatographic device comprising:

an inlet system, a column and a pressure reducing means disposed therebetween for reducing pressure between an inlet of said pressure reducing means and an outlet of said column, said outlet of said column being under vacuum wherein said column is a wide bore column, wherein said pressure reducing means is formed by a capillary tube having and internal diameter in a range between 0.1 mm to 5.0 mm.

2. The gas chromatographic device of claim 1, wherein the pressure prevailing at said inlet of said pressure reducing means is in a range between 10 kPa, and 1000 kPa and pressure prevailing at said outlet of said column is substantially below an atmospheric pressure.

3. The gas chromatographic device of claim 1, wherein the pressure prevailing at an outlet of said pressure reducing means is in a range between 0.00001 kPa to 50 kPa.

4. The gas chromatographic device of claim 2, wherein said pressure reducing means is an integral part of said inlet system.

5. The gas chromatographic device of claim 2, wherein said pressure reducing means is an integral part of said column.

6. The gas chromatographic device of claim 2, wherein said pressure reducing means is made of a material selected from the group consisting of silica, glass, metal, an organic polymer, and an inorganic polymer.

7. The gas chromatographic device of claim 2, wherein said pressure reducing means is made of a combination of materials selected from the group consisting of silica, glass, metal, an organic polymer, and an inorganic polymer.

8. The gas chromatographic device of claim 2, wherein said pressure reducing means has a coiled tubular shape.

9. The gas chromatographic device of claim 2, wherein said pressure reducing means is formed by a capillary tube having a length in a range between 1 mm and 2500 mm.

10. The gas chromatographic device of claim 9, wherein said capillary tube is packed with particles, having an average size in a range between 0.5 μ

m and 500 μ

m.

11. The gas chromatographic device of claim 10, wherein said capillary tube is packed with deactivated particles.

12. The gas chromatographic device of claim 10, wherein said capillary tube is packed with non-deactivated particles.

13. A gas chromatographic device comprising:

an inlet system, a wide bore column having an inlet and an outlet, and a pressure reducing means, said pressure reducing means being coupled to said outlet of said wide bore column for providing a vacuum condition at an outlet of said pressure reducing means, wherein said pressure reducing means is an integral part of said wide bore column.

14. The gas chromatographic device of claim 13, wherein said outlet pressure of said column is substantially equal to an inlet pressure of said inlet system, and said outlet pressure of said pressure reducing means is substantially below an atmospheric pressure.

15. The gas chromatographic device of claim 14, wherein said pressure reducing means is a bore fused silica capillary tube having a length in a range between 5 mm and 500 mm, and an internal diameter in a range between 0.1 mm and 5.0 mm, said capillary tube is packed with particles having an average size in a range between 0.5 μ

m to 500 μ

m.

16. The gas chromatographic device of claim 15, wherein said bore fused silica capillary tube has a length in a range between 20 mm and 100 mm, and an internal diameter in a range between 0.2 mm and 2.0 mm, said capillary tube is packed with particles having an average size in a range between 5 μ

m to 50 μ

m.

17. The gas chromatographic device of claim 16, wherein said capillary tube is packed with deactivated particles.

18. The gas chromatographic device of claim 16, wherein said capillary tube is packed with non-deactivated particles.

19. The gas chromatographic device of claim 15, wherein said pressure reducing means has an internal diameter in a range between 0.001 mm and 0.2 mm, and a length in a range between 1 mm and 2500 mm.

20. A chromatography column for a gas chromatographic device comprising:

an inlet and an outlet; and

a pressure reducing means being an integral part of the column for reducing the pressure prevailing at said inlet to a pressure that is substantially below an atmospheric pressure, wherein said column is a wide bore column that has a length in a range between 0.25 m and 100 m, and has an internal diameter in a range between 0.05 mm and 1.0 mm.

21. The chromatography column of claim 20, wherein said pressure reducing means further comprising an inlet and an outlet, and said pressure reducing means is made of a material or combination of materials selected from the group consisting of silica, glass, metal, an organic polymer, and an inorganic polymer.

22. The chromatography column of claim 21, wherein said column and said pressure reducing means are made of essentially the same material.

23. The chromatography column of claim 21, wherein said outlet of said chromatography column is connected to said inlet of said pressure reducing means forming an integral part therewith.

24. The chromatography column of claim 21, wherein said inlet of said chromatography column is connected to said outlet of said pressure reducing means forming an integral part therewith.