Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
First Claim
1. A method for treating degenerative skin conditions in a subject in need thereof, said method comprising applying at least one electric pulse to the surface of a region of skin and applying thereto a composition comprising L-ascorbic acid, or a cosmetically/pharmaceutically acceptable salt, ester or other derivative thereof, said electric pulse having a voltage from about 25 volts to about 120 volts and sufficient duration to cause electroporation of said region of skin, thereby delivering an effective amount of the L-ascorbic acid or the derivative thereof through the stratum corneum of the region of skin so as to improve the condition of the region of skin without substantial pain or skin irritation.
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Abstract
The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical damage on skin. Sufficient electric pulses applied to a region of skin surface temporarily create new pathways through the lipid skin barrier, thereby delivering an L-ascorbic acid-containing composition through the lipid skin barrier and enhancing production of collagen in the region of the skin so treated. A handheld electrical pulser apparatus, optionally table-top adaptable, and methods of use for cosmetic treatment of degenerative skin conditions are provided by the invention.
210 Citations
54 Claims
- 1. A method for treating degenerative skin conditions in a subject in need thereof, said method comprising applying at least one electric pulse to the surface of a region of skin and applying thereto a composition comprising L-ascorbic acid, or a cosmetically/pharmaceutically acceptable salt, ester or other derivative thereof, said electric pulse having a voltage from about 25 volts to about 120 volts and sufficient duration to cause electroporation of said region of skin, thereby delivering an effective amount of the L-ascorbic acid or the derivative thereof through the stratum corneum of the region of skin so as to improve the condition of the region of skin without substantial pain or skin irritation.
- 27. A method for electroporation-enhanced dermatological delivery of L-ascorbic acid through the stratum corneum of a subject in need thereof, said method comprising applying at least one electric pulse to the surface of a region of skin so as to cause electroporation of the region of skin and applying thereto a composition comprising ascorbic acid, or a cosmetically/pharmaceutically acceptable salt, ester or other derivative thereof, said electric pulse having a voltage from about 25 volts to about 120 volts and sufficient duration to topically deliver an effective amount of the L-ascorbic acid or the derivative to the region of skin.
Specification