Body cleansing agent

• US 6,303,109 B1
• Filed: 10/12/1999
• Issued: 10/16/2001
• Est. Priority Date: 03/12/1997
• Status: Expired due to Fees

• Current Assignee: Henkel KGaA (Henkel AG & Co KGaA)
• Original Assignee: Henkel KGaA (Henkel AG & Co KGaA)
• Inventors: Schmitt, Michael, Pittermann, Wolfgang, Foerster, Thomas, Scholz, Wolfhard, Hollenbrock, Martina
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): MCQUEENEY, PATRICIA E
• Application Number:
  US09/380,881
• Time in Patent Office: 735 Days
• Field of Search: 424/59, 424/70.1, 424/70.19, 424/70.21, 424/70.22, 424/70.24, 424/70.31, 424/70.9, 424/401, 424/450, 424/489, 424/490, 424/498
• US Class Current: 424/70.31
• CPC Class Codes: A61K 8/0291 Micelles
• CPC Class Codes: A61K 8/0295 Liquid crystals
• CPC Class Codes: A61K 8/068 Microemulsions
• CPC Class Codes: A61K 8/678 Tocopherol, i.e. vitamin E
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: Y10S 977/926 Topical chemical, e.g. cosmetic or sunscreen

Abstract

The invention relates to lipid soluble, water insoluble cosmetic or dermatological active substances which can be included in body cleansing agents in the form of an aqueous preparation with at least 5 wt. % water soluble ionic or non-ionic surfactant content by solubilization of the active substances with a polar lipid in lipid-surfactant mixed micelles or liquid crystals or by microemulsification with a nonpolar lipid, wherein the emulsion particles have a diameter which is less than 500 nm. Said agents are also characterized by enhanced skin penetration by the active substances.

Claims

1. An aqueous body wash composition comprising:

(a) at least 5 percent by weight of a water-soluble surfactant or surfactants; and

(b) at least 0.05 percent by weight of a lipid-soluble, water-insoluble active substance, wherein the active substance is solubilized with a polar lipid in a lipid/surfactant mixed micelle or liquid crystal, or is microemulsified with a non-polar lipid wherein the emulsion droplets have a diameter of less than 500 nm, and wherein The water-soluble surfactant or surfactants comprise (i) a mixture of an anionic sulfate or sulfonate surfactant and a zwitterionic betaine surfactant, or (ii) a mixture of an anionic surface and an alkyl glycoside surfactant.

2. The aqueous body wash composition of claim 1 wherein the amount of the water soluble surfactant or surfactants is sufficient to solubilize or microemulsify said active substance to render said composition washable with water.

3. The aqueous body wash composition of claim 2 wherein the water soluble surfactant or surfactants is present in the composition in an amount from 5 to 30 percent by weight.

4. The aqueous body wash composition of claim 1 wherein the water-soluble surfactant comprises the mixture of the anionic sulfate or sulfonate surfactant and the zwitterionic betaine surfactant.

5. The aqueous body wash composition of claim 1 wherein the water-soluble surfactant comprises the mixture of the anionic surfactant and the alkyl glycoside surfactant.

6. The aqueous body wash composition of claim 1 comprising 0.1 to 1 percent by weight of the lipid-soluble active substance.

7. The aqueous body wash composition of claim 1 comprising a lipid-soluble vitamin as the active substance.

8. The aqueous body wash composition of claim 1 comprising tocopherols or lipid-soluble derivatives thereof as the active substance.

9. The aqueous body wash composition of claim 1 wherein the polar lipid comprises a linear C_12-22 fatty alcohol, a linear C_12-22 alkanediol, a C_12-22 fatty acid partial ester of a C_3-8 polyol containing 2 to 6 hydroxyl groups or a C_8-2 fatty acid monoalkanolamide of a C₂ or C₃ alkanolamine.

10. The aqueous body wash composition of claim 1 wherein the non-polar lipid comprises a paraffin solid at 20°

C., a fatty acid (C_12-22) triglyceride, a wax ester or a mixture thereof.

11. The aqueous body wash composition of claim 1 wherein the weight ratio of the polar lipid or the non-polar lipid to the active substance is from 5:

1 to 50;

1.

12. The aqueous body wash composition of claim 1 wherein the emulsion droplets have a diameter of 100 to 200 nm.

13. A process of washing or cleansing skin or hair comprising forming an aqueous body wash composition according to claim 1, applying a washing or cleansing-effective amount of said aqueous body wash composition to the skin or hair for a time sufficient to effect washing or cleansing of the skin or hair, and removing said aqueous body wash composition with water, whereby the active substance is absorbed into the skin or hair.

14. The process of claim 13 wherein the aqueous body wash composition is formed by first forming a concentrate comprising 1 to 10 percent by weight of the active substance solubilized in lipid/surfactant mixed micelle or liquid crystal, then mixing said concentrate with an aqueous body wash.

15. The process of claim 14 wherein the weight ratio of the lipid to the surfactant is 1:

2 to 2;

1 and the weight ratio of the polar lipid to the active substance is 10;

0.2 to 10;

2.