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Antisense modulation of caspase 3 expression

  • US 6,303,374 B1
  • Filed: 01/18/2000
  • Issued: 10/16/2001
  • Est. Priority Date: 01/18/2000
  • Status: Expired due to Term
First Claim
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1. The antisense co pound up to 30 nucleobases in length targeted to a nucleic acid molecules encoding caspase 3, wherein said antisense compound comprises at least an 8 nucleobase portion of SEQ ID NO:

  • 18, 19, 20, 23, 24, 25, 26, 27, 30, 31, 32, 33, 34, 35, 36, 38, 39, 40, 41, 42, 44, 46, 47, 48, 50, 51, 54, 55, 56, 57, 59, 61, 63, 64, 65, 67, 68, 71, 72, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 89, 91, 92, 94, 95,96, 97, 98, 101, 102, 103, 106, 107, 108, 113, 114, 116, 117, 118, 119, 120, 121, 122, 124, 126, 127, 129, 131, 133, 140, 142, 143, 146, 150, 151, 154, 159, 160, 164, 167 or 169 and wherein said antisense compound specifically hybridizes with and inhibits the expression of said nucleic acid molecule encoding caspase 3.

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