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Systems and methods for imaging fluorophores

  • US 6,304,771 B1
  • Filed: 01/15/1997
  • Issued: 10/16/2001
  • Est. Priority Date: 10/29/1993
  • Status: Expired due to Term
First Claim
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1. A system for imaging fluorophores in a turbid medium comprising:

  • an illumination source that illuminates the fluorophores with diffuse photon density waves of a first specified wavelength, thus causing the fluorophores to fluoresce re-radiated diffuse photon density waves of a second wavelength after being illuminated with the diffuse photon density waves of the first specified wavelength;

    a detector that detects the re-radiated diffuse photon density waves of the second wavelength, wherein there is a phase shift between the diffuse photon density waves of the first wavelength and the diffuse photon density waves of the second wavelength; and

    a processor interfaced with the detector that processes data corresponding to the phase shift and the amplitude of the re-radiated waves to determine concentration and lifetime of the fluorophores as a function of spatial position in the turbid medium.

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