Apparatus and method for non-invasively measuring cardiac output

• US 6,306,098 B1
• Filed: 12/19/1996
• Issued: 10/23/2001
• Est. Priority Date: 12/19/1996
• Status: Expired due to Term

• Current Assignee: RIC INVESTMENTS LLC (Koninklijke Philips N.V.)
• Original Assignee: Novametrix Medical Systems, Inc. (Dixtal Medical, Inc.)
• Inventors: Orr, Joseph A., Jaffe, Michael B., Westenskow, Dwayne, Kofoed, Scott A.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/770,138
• Time in Patent Office: 1,769 Days
• Field of Search: 128/200.26, 128/207.14, 128/207.15, 128/207.16, 600/483, 600/484, 600/485, 600/532, 600/529, 600/531, 600/543, 600/481, 600/526
• US Class Current: 128/200.26
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61M 16/0045 Means for re-breathing exhaled gases, e.g. for hyperventilation treatment
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)
• CPC Class Codes: G01N 33/004 CO or CO2
• CPC Class Codes: Y02A 50/20 Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters

Abstract

Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO₂ values rather than end-tidal CO₂ values as previously practiced. A program for calculating cardiac output is also disclosed.

Claims

1. Apparatus for non-invasive determination of cardiac output, comprising:

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit;

a volume-adjustable deadspace comprising a plurality of shunt lines positioned in fluid communication between said expiratory conduit and said inspiratory conduit, each said shunt line including a selectively actuatable shunt valve providing movement of exhaled gas between said inspiratory conduit and said expiratory conduit; and

detection apparatus positioned in proximity to said airway conduit for detecting a change in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

2. The apparatus of claim 1, further comprising a source of ventilation in communication with said airway conduit to provide gas to the patient.

3. Apparatus for non-invasive determination of cardiac output comprising:

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit, at least one of said expiratory conduit and said inspiratory conduit including at least one volume-expandable section

a volume-adjustable deadspace comprising at least one shunt line positioned in fluid communication between said expiratory conduit and said inspiratory conduit, said at least one volume-expandable section being positioned to selectively expand said volume-adjustable deadspace; and

detection apparatus positioned in proximity to said airway conduit for detecting a change in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

4. The apparatus of claim 3, further comprising a source of ventilation in communication with said airway conduit to provide gas to a patient.

5. The apparatus of claim 3, further comprising a plurality of shunt lines extending between said expiratory conduit and said inspiratory conduit, each said shunt line having a selectively actuatable shunt valve providing movement of exhaled gas between said inspiratory conduit and said expiratory conduit.

6. Apparatus for non-invasive determination of cardiac output, comprising:

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit;

a volume-adjustable deadspace comprising a length of conduit in communication with at least said airway conduit, said length of conduit comprising a volume-expandable section; and

detection apparatus positioned in proximity to said airway conduit for detecting a change in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

7. The apparatus of claim 6, further comprising a valve configured for selectively directing gas through said length of conduit.

8. The apparatus of claim 6, further comprising a source of ventilation in communication with said airway conduit to provide gas to a patient.

9. The apparatus of claim 6, wherein said length of conduit further comprises an inlet, an outlet and a restrictor valve positioned therebetween in said airway conduit, and further comprising a valve positioned to selectively effect closure of a path through said volume-adjustable deadspace between said inlet and said outlet.

10. The apparatus of claim 9, further comprising a source of ventilation in communication with said airway conduit to provide gas to a patient.

11. Apparatus for non-invasive determination of cardiac output, comprising:

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit;

a volume-adjustable deadspace comprising a selectively length-expandable section in communication between said airway conduit and said expiratory conduit and a selectively length-expandable section in communication between said airway conduit and said inspiratory conduit; and

detection apparatus positioned in proximity to said airway conduit for detecting a change in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

12. Apparatus for non-invasive determination of cardiac output comprising:

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit;

a volume-adjustable deadspace comprises an expandable section of conduit in communication between said airway conduit and a source of ventilation gas; and

detection apparatus positioned in proximity to said airway conduit for detecting a chance in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

13. Apparatus for non-invasive determination of cardiac output, comprising:

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit;

a volume-adjustable deadspace including an evacuation line connected to said expiratory conduit and a gas releasing structure for evacuating gas from said evacuation line to reduce the volume of said deadspace; and

detection apparatus positioned in proximity to said airway conduit for detecting a change in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

14. The apparatus of claim 13, further comprising a compliant receptacle in communication with said evacuation line and configured to receive evacuated exhaled gas.

15. Apparatus for non-invasive determination of cardiac outputs comprising;

an airway conduit adapted for communication with a patient'"'"'s respiratory system;

an inspiratory conduit interconnected to said airway conduit;

an expiratory conduit interconnected to said airway conduit;

a volume-adjustable deadspace provided by a tracheal gas insufflation device; and

detection apparatus positioned in proximity to said airway conduit for detecting a change in concentration of at least one gas and in gas flow relating to said patient'"'"'s respiratory system.

16. Apparatus for non-invasively determining cardiac output of a patient comprising an airway conduit for contact with a patient'"'"'s airway, an inspiratory conduit connected to said airway conduit and an expiratory conduit connected to said airway conduit, said expiratory conduit being structured with an evacuation line for selectively evacuating an amount of exhaled gas from said patient and a selectively-adjustable valve connected to said evacuation line for releasing an amount of exhaled gas through said evacuation line.

17. The apparatus of claim 16 further comprising an evacuation port for releasing gas, and further comprising a compliant receptacle connected thereto for receiving said exhaled gas.

18. The apparatus of claim 16 further comprising a source of ventilation in communication with said airway conduit to provide gas to a patient.

19. Apparatus for non-invasively determining cardiac output of a patient comprising an airway conduit adapted to be contacted with a patient'"'"'s airway, a source of gas in communication with said airway conduit, a gas insufflation conduit extending from said source of gas to said patient'"'"'s lungs and positioned in tandem with said airway conduit to directly deliver gas to a patient'"'"'s lungs for insufflation thereof, a source of ventilation connected to said airway conduit for providing gas thereto, an inspiratory conduit interconnected between said source of ventilation and said airway conduit and an expiratory conduit interconnected between said source of ventilation and said airway conduit, said gas insufflation conduit and airway conduit being sized and positioned to provide an intermittent deadspace from which a patient can re-breath exhaled gas.

20. A method for non-invasively measuring cardiac output comprising:

providing ventilation apparatus for measuring pulmonary gas output of a patient, said apparatus including an airway conduit for contact with a patient'"'"'s trachea, an inspiratory tube connected to said airway conduit, an expiratory tube connected to said airway conduit and a deadspace connected to said airway conduit;

placing said airway conduit in fluid communication with a patient'"'"'s trachea to provide ingress and egress of air therethrough;

initiating normal breathing in the patient;

measuring the volume of gas and end-tidal gas concentration for a selected period of ventilation to establish a baseline gas concentration and gas volume output;

calculating the end-tidal concentration of gas and calculating the concentration of gas over the period of one inhalation and one exhalation;

calculating the concentration of gas during exhalation and calculating anatomic deadspace;

determining a correction value for alveolar deadspace from said calculated concentration of gas over the period of one inhalation and one exhalation;

determining a correction value for parallel deadspace from said calculated end-tidal gas concentration;

introducing a change in ventilation by directing exhaled gas from the patient into said deadspace of said ventilation apparatus for re-breathing by the patient;

measuring the change in gas volume and gas concentration during an episode of re-breathing;

repeating said normal breathing and measuring of said volume of gas and end-tidal gas concentration, and recalculating end-tidal gas concentration, gas concentration over inhalation and exhalation and gas concentration during inspiration;

redetermining said correction value for parallel deadspace; and

calculating the difference between said baseline gas concentrations and volume of gas output with the detected change in gas concentration and gas volume output following re-breathing.

21. The method according to claim 20 wherein said deadspace of said ventilation apparatus is volume-adjustable, said method further comprising:

adjusting said volume-adjustable deadspace of said ventilation apparatus responsive to a perceived variance from a selected value of gas concentration per volume of gas prior to repeating said normal breathing.

22. The method according to claim 21 wherein said measured gas is CO₂ expelled from the lungs of said patient.

23. The method according to claim 22 wherein said adjusting of said volume-adjustable deadspace comprises expanding the volume of said deadspace responsive to a perceived value of expelled gas volume less than twenty percent of said baseline value of expelled gas volume.

24. The method according to claim 22 wherein said adjusting of said volume-adjustable deadspace comprises expanding the volume of said deadspace responsive to a perceived change in value of an alveolar gas concentration less than 3 mm Hg partial pressure.

25. The method according to claim 22 wherein said adjusting of said volume-adjustable deadspace comprises decreasing the volume of said deadspace responsive to a perceived value of greater than eighty percent of said baseline expelled gas volume.

26. The method according to claim 22 wherein said adjusting of said volume-adjustable deadspace comprises evacuating a portion of said exhaled re-breathed gas from said deadspace.