Aerosol formulation containing a particulate medicament
First Claim
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1. An aerosol formulation comprising:
- (i) a hydrogen-containing fluorocarbon or chlorofluorocarbon propellant which is selected from the group consisting of CH2ClF, CClF2—
CHClF, CF3—
CHClF, CHF2—
CClF2, CHClF—
CHF2, CF3—
CH2Cl, CHF2—
CHF2, CF3—
CH2F, CClF2—
CH3, CHF2—
CH3 and CF3CHFCF3;
(ii) a cosolvent having higher polarity than the propellant, which cosolvent is present in an amount of less than 1% w/w based upon the weight of propellant; and
(iii) a medicament in particulate form, said medicament having a particle size of less than 100 μ
m and having a surface coating of a surfactant in an amount of from 0.05 to 5% w/w based upon the weight of the medicament, and wherein said surfactant has no affinity for said propellant.
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Abstract
Aerosol formulations comprising:
(A) A medicament in particulate form and having a surface coating of a surfactant;
(B) A hydrogen-containing fluorocarbon or chlorofluorocarbon propellant; and
(C) A cosolvent having higher polarity than the propellant which cosolvent is present in an amount of up to 5% w/w based upon propellant;
and methods for their preparation.
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Citations
7 Claims
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1. An aerosol formulation comprising:
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(i) a hydrogen-containing fluorocarbon or chlorofluorocarbon propellant which is selected from the group consisting of CH2ClF, CClF2—
CHClF, CF3—
CHClF, CHF2—
CClF2, CHClF—
CHF2, CF3—
CH2Cl, CHF2—
CHF2, CF3—
CH2F, CClF2—
CH3, CHF2—
CH3 and CF3CHFCF3;
(ii) a cosolvent having higher polarity than the propellant, which cosolvent is present in an amount of less than 1% w/w based upon the weight of propellant; and
(iii) a medicament in particulate form, said medicament having a particle size of less than 100 μ
m and having a surface coating of a surfactant in an amount of from 0.05 to 5% w/w based upon the weight of the medicament, and wherein said surfactant has no affinity for said propellant.- View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification