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Aerosol formulation containing a particulate medicament

  • US 6,306,368 B1
  • Filed: 11/24/1998
  • Issued: 10/23/2001
  • Est. Priority Date: 11/09/1990
  • Status: Expired due to Fees
First Claim
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1. An aerosol formulation comprising:

  • (i) a hydrogen-containing fluorocarbon or chlorofluorocarbon propellant which is selected from the group consisting of CH2ClF, CClF2

    CHClF, CF3

    CHClF, CHF2

    CClF2, CHClF—

    CHF2, CF3

    CH2Cl, CHF2

    CHF2, CF3

    CH2F, CClF2

    CH3, CHF2

    CH3 and CF3CHFCF3;

    (ii) a cosolvent having higher polarity than the propellant, which cosolvent is present in an amount of less than 1% w/w based upon the weight of propellant; and

    (iii) a medicament in particulate form, said medicament having a particle size of less than 100 μ

    m and having a surface coating of a surfactant in an amount of from 0.05 to 5% w/w based upon the weight of the medicament, and wherein said surfactant has no affinity for said propellant.

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