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Aerosol formulations containing P134a and particulate medicament

  • US 6,306,369 B1
  • Filed: 04/28/2000
  • Issued: 10/23/2001
  • Est. Priority Date: 12/12/1991
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical aerosol formulation comprising:

  • (a) an effective amount of a particulate bronchodilatory medicament;

    (b) an effective amount of a particulate anti-inflammatory medicament; and

    (c) 1,1,1,2-tetrafluoroethane as propellant;

    which formulation contains less than 0.0001% surfactant by weight of the medicaments;

    with the proviso that such medicaments are other than salmeterol, salbutamol, fluticasone propionate, beclomethasone dipropionate or a physiologically acceptable salt or solvate thereof, and wherein the particulate medicaments being present in an amount of 0.005% to 5% w/w relative to the total weight of the formulation and having a particle size of less than 100 microns.

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