Methods for reducing the incidence of necrotizing enterocolitis
First Claim
1. A method for reducing the incidence of necrotizing enterocolitis in an infant, said method comprising administering to an infant which is susceptible to necrotizing enterocolitis an effective amount of a composition comprising protein, carbohydrate and lipid, including at least 1.0 mg of ω
- -6 polyunsaturated fatty acids per kg per day.
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Abstract
Enteral formulas that contain long-chain polyunsaturated fatty acids (PUFAs), e.g., arachidonic acid (AA), and docosahexaenoic acid (DHA), essentially free of cholesterol, are described for use in methods for reducing the incidence of necrotizing enterocolitis. Compositions from egg yolk lipids are preferred as they contain ω-6 and ω-3 long chain PUFAs and are predominantly in a phosphtidylcholine form. This is believed to provide a synergetic effect.
114 Citations
27 Claims
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1. A method for reducing the incidence of necrotizing enterocolitis in an infant, said method comprising administering to an infant which is susceptible to necrotizing enterocolitis an effective amount of a composition comprising protein, carbohydrate and lipid, including at least 1.0 mg of ω
- -6 polyunsaturated fatty acids per kg per day.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for providing nutrition to an infant susceptible to or having necrotizing enterocolitis, said method comprising enterally administering to said infant an effective amount of at least one ω
- -6 polyunsaturated fatty acid in a nutritional matrix comprising protein, carbohydrate and fats, said matrix providing at least 1.0 mg of ω
-6 polyunsaturated fatty acids per kg per day. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
- -6 polyunsaturated fatty acid in a nutritional matrix comprising protein, carbohydrate and fats, said matrix providing at least 1.0 mg of ω
Specification