Method and apparatus for guiding ablative therapy of abnormal biological electrical excitation

• US 6,308,093 B1
• Filed: 10/07/1999
• Issued: 10/23/2001
• Est. Priority Date: 10/07/1999
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Cohen, Richard J., Sherman, Derin A., Armoundas, Antonis A., Feldman, Andrew B.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/413,969
• Time in Patent Office: 747 Days
• Field of Search: 607/2, 607/115, 600/509, 600/508, 600/515, 600/427, 600/486
• US Class Current: 600/509
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 5/062 using magnetic field
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61N 1/06 for high-frequency therapy
• CPC Class Codes: G01V 3/02 operating with propagation of electric current

Abstract

This invention involves method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. In particular, it is designed for treatment of cardiac arrhythmias. In the method of this invention electrical signals are acquired from passive electrodes, and an inverse dipole method is used to identify the site of origin of an arrhytmia. The location of the tip of the ablation catheter is similarly localized from signals acquired from the passive electrodes while electrical energy is delivered to the tip of the catheter. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.

Claims

1. A method for localizing an electrical source in the body comprising:

placing passive electrodes on the body;

placing at least one active electrode in the body;

acquiring from the passive electrodes signals emanating from the electrical source;

processing the signals emanating from the electrical source to determine the relative location of the electrical source;

delivering electrical energy to the at least one active electrode;

acquiring from the passive electrodes the signals emanating from the at least one active electrode;

processing the signals emanating from the at least one active electrode to determine the relative location of the at least one active electrode;

positioning the at least one active electrode to localize the electrical source.

5. The method of claim 1, 2, 3, or 4 wherein the positioning step involves approximating the relative locations of the at least one active electrode and the electrical source.

6. The method of claim 1, 2, 3, or 4 wherein the delivering step, the second acquiring step, the second processing step, and the positioning step are performed iteratively.

7. The method of claim 1, 2, 3, or 4 wherein the electrical source is located in the heart.

8. The method of claim 7 wherein the electrical source is the site of origin of an arrhythmia.

9. The method of claim 7 wherein the first processing step is used to determine the relative location of the electrical source at a multiplicity of time epochs during the cardiac cycle.

10. The method of claim 9 wherein the positioning step localizes the electrical source at one of the time epochs.

11. The method of claim 10 wherein at least one criterion is used to choose the time epoch.

12. The method of claim 1, 2, 3, or 4 wherein at least one of the processing steps involves fitting the acquired signals to a moving dipole model.

13. A method for delivering ablative energy in the vicinity of the location of an electrical source comprising the method of claim 1, 2, 3, or 4 and further comprising the delivery of ablative energy in the vicinity of the location of the at least one active electrode.

14. The method of claim 13 wherein the at least one active electrode is located on a catheter.

15. The method of claim 14 wherein the ablative energy is delivered through the catheter.

16. The method of claim 13 wherein the ablative energy is radio frequency electrical energy.

17. The method of claim 1, 2, 3, or 4 wherein the electrical source is located in the brain.

19. The method of claim 1, 2, 3, or 4 further comprising the displaying of the relative location of the electrical source.

20. The method of claim 1, 2, 3, or 4 further comprising the displaying of at least one measure selected from the group consisting of a measure of the size of an electrical source, a measure of the strength of an electric source, and a measure of the uncertainty in the relative location of the electric source.

2. A method for localizing an electrical source in the body comprising:

placing passive electrodes on the body;

placing at least one active electrode on the body;

acquiring from the passive electrodes signals emanating from the electrical source;

processing the signals emanating from the electrical source to determine the relative location of the electrical source;

delivering electrical energy to the at least one active electrode;

acquiring from the passive electrodes the signals emanating from the at least one active electrode;

processing the signals emanating from the at least one active electrode to determine the relative location of the at least one active electrode;

positioning the at least one active electrode to localize the electrical source.

3. A method for localizing an electrical source in the body comprising:

placing passive electrodes in the body;

placing at least one active electrode on the body;

acquiring from the passive electrodes signals emanating from the electrical source;

processing the signals emanating from the electrical source to determine the relative location of the electrical source;

delivering electrical energy to the at least one active electrode;

acquiring from the passive electrodes the signals emanating from the at least one active electrode;

processing the signals emanating from the at least one active electrode to determine the relative location of the at least one active electrode;

positioning the at least one active electrode to localize the electrical source.

18. The method of claim 3 or claim 4 wherein at least one of the passive electrodes is placed within the heart.

4. A method for localizing an electrical source in the body comprising:

placing passive electrodes in the body;

placing at least one active electrode in the body;

acquiring from the passive electrodes signals emanating from the electrical source;

processing the signals emanating from the electrical source to determine the relative location of the electrical source;

delivering electrical energy to the at least one active electrode;

acquiring from the passive electrodes the signals emanating from the at least one active electrode;

processing the signals emanating from the at least one active electrode to determine the relative location of the at least one active electrode;

positioning the at least one active electrode to localize the electrical source.

21. A method for localizing an electrical source in the body comprising:

placing passive electrodes on the body;

placing at least one active electrode in the body;

acquiring from the passive electrodes signals emanating from the electrical source;

processing the signals emanating from the electrical source to determine the relative location of the electrical source at a multiplicity of time epochs during the cardiac cycle, wherein the processing involves fitting the signals to a moving dipole model;

delivering electrical energy to the at least one active electrode;

acquiring from the passive electrodes the signals emanating from the at least one active electrode;

processing the signals emanating from the at least one active electrode to determine the relative location of the at least one active electrode, wherein the processing involves fitting the signals to a moving dipole model; and

positioning the at least one active electrode to localize the electrical source at one of the time epochs, wherein at least one criterion is used to choose the time epoch; and

wherein the delivering step, the second acquiring step, the second processing step, and the positioning step are performed iteratively.

22. A method for delivering ablative energy in the vicinity of the location of an electrical source comprising the method of claim 21 and further comprising the delivery of ablative energy in the vicinity of the location of the at least one active electrode, wherein the at least one active electrode is located on a catheter, wherein the ablative energy is delivered through the catheter, and wherein the electrical source is the site of origin of a cardiac arrhythmia.

23. An apparatus for localizing an electrical source within the body comprising:

at least one passive electrode adapted for placement on the body;

at least one active electrode adapted for placement in the body;

a signal generator for delivering electrical energy to the at least one active electrode; and

a computer for processing the signals emanating from the electrical source and the at least one active electrode to determine the relative location of the electrical source and the relative location of the at least one active electrode.

27. The apparatus of claim 23, 24, 25, or 26 wherein the electrical source is located in the heart.

28. The apparatus of claim 27 wherein the electrical source is the site of origin of an arrhythmia.

29. The apparatus of claim 23, 24, 25, or 26 wherein the computer fits the signals emanating from the electrical source to a moving dipole model.

30. The apparatus of claim 23, 24, 25, or 26 wherein the computer fits the signals emanating from the at least one active electrode to a moving dipole model.

31. The apparatus of claim 23, 24, 25, or 26 wherein the computer fits the signals acquired from the passive electrodes to a moving dipole model.

32. The apparatus of claim 23, 24, 25, or 26 further comprising an isolation amplifier for isolating the signals acquired from the passive electrodes;

and an amplifier bank for amplifying the signals acquired from the passive electrodes.

33. The apparatus of claim 23, 24, 25, or 26 further comprising a low-pass filter for identifying the signals emanating from the electrical source.

34. The apparatus of claim 23, 24, 25, or 26 further comprising a lock-in amplifier for identifying signals emanating from the at least one active electrode.

35. The apparatus of claim 23, 24, 25, or 26 further comprising a display.

36. An apparatus for delivering ablative energy in the vicinity of the location of an electrical source comprising the apparatus of claim 23, 24, 25, or 26 and further comprising a source of ablative energy for delivery in the vicinity of the at least one active electrode.

37. The apparatus of claim 36 further comprising a catheter.

38. The apparatus of claim 37 wherein the at least one active electrode is located on the catheter.

39. The apparatus of claim 38 wherein the ablative energy is delivered through the catheter.

40. The apparatus of claim 36 wherein the ablative energy is radio frequency electrical energy.

41. The apparatus of claim 23, 24, 25, or 26 wherein the electrical source is located in the brain.

42. An apparatus for delivering ablative energy in the vicinity of the location of an electrical source comprising the apparatus of claim 31 and further comprising:

an isolation amplifier for isolating the signals acquired from the passive electrodes; and

an amplifier bank for amplifying the signals acquired from the passive electrodes;

a low-pass filter for identifying the signals originating from the electrical source;

a lock-in amplifier for identifying the signals emanating from the at least one active electrode;

a catheter, wherein the at least one active electrode is located on the catheter;

a source of ablative energy for delivery in the vicinity of the at least one active electrode, wherein the ablative energy is delivered through the catheter; and

a display.

24. An apparatus for localizing an electrical source within the body comprising:

at least one passive electrode adapted for placement on the body;

at least one active electrode adapted for placement on the body;

a signal generator for delivering electrical energy to the at least one active electrode; and

a computer for processing the signals emanating from the electrical source and the at least one active electrode to determine the relative location of the electrical source and the relative location of the at least one active electrode.

25. An apparatus for localizing an electrical source within the body comprising:

at least one passive electrode adapted for placement in the body;

at least one active electrode adapted for placement on the body;

a signal generator for delivering electrical energy to the at least one active electrode; and

a computer for processing the signals emanating from the electrical source and the at least one active electrode to determine the relative location of the electrical source and the relative location of the at least one active electrode.

26. An apparatus for localizing an electrical source within the body comprising:

at least one passive electrode adapted for placement in the body;

at least one active electrode adapted for placement in the body;

a signal generator for delivering electrical energy to the at least one active electrode; and

a computer for processing the signals emanating from the electrical source and the at least one active electrode to determine the relative location of the electrical source and the relative location of the at least one active electrode.