Ultrasound enhanced chemotherapy
First Claim
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1. A method of anti-cancer drug delivery comprising the steps of:
- introducing an anti-cancer drug into a solid tumor within a body; and
transcutaneous introducing ultrasonic energy into the solid tumor while the anti-cancer drug is present therein, the ultrasonic energy being less than about 100 kHz at less than about 50 watts in order to prevent heating of the tumor.
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Abstract
Apparatus and method is provided for enhancing the action of anti-cancer agents, which includes the introduction of anti-cancer agent into or proximate a tumor within a body and thereafter introducing ultrasonic energy at the solid tumor with the introduced anti-cancer agent. The ultrasonic energy is sufficient to increase the anti-cancer activity on the solid tumor without significant heating of the solid tumor or surrounding tissue.
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Citations
28 Claims
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1. A method of anti-cancer drug delivery comprising the steps of:
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introducing an anti-cancer drug into a solid tumor within a body; and
transcutaneous introducing ultrasonic energy into the solid tumor while the anti-cancer drug is present therein, the ultrasonic energy being less than about 100 kHz at less than about 50 watts in order to prevent heating of the tumor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 23)
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9. A method of anti-cancer drug delivery comprising the steps of:
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introducing an anti-cancer drug proximate cancer cells; and
promoting intracellular activation by irradiating the cancer cells with ultrasound to cause passage of the anti-cancer drug into the cancer cells, the ultrasound having the energy of less than about 50 watts and a frequency of less than 100 kHz in order to prevent heating of the cancer cell. - View Dependent Claims (10, 11, 12, 13, 24)
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14. A method for enhancing the action of an anti-cancer agent in the treatment of a solid tumor, said method comprising the steps of:
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introducing an anti-cancer agent into a solid tumor within a body; and
introducing ultrasonic energy into the solid tumor, said ultrasonic energy being of sufficient energy to increase the anti-cancer activity of the agent on the solid tumor without significant heating of the solid tumor or surrounding tissue, said ultrasonic energy being less than about 100 kHz at less than about 50 watts in order to prevent heating of the tumor. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 25)
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22. A method for inhibiting the sequence of angiogenesis of cancer cells in a tumor, the method comprising the steps of:
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transcutaneous introducing an antiangiogenesis agent proximate the cancer cells within the tumor; and
introducing ultrasonic energy into the tumor while the antiangiogeneses agent is present therein, the ultrasonic energy being less than 100 kHz at less that 50 watts in order to prevent heating of the tumor. - View Dependent Claims (26, 27, 28)
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Specification