Method and assembly for performing ultrasound surgery using cavitation

• US 6,309,355 B1
• Filed: 12/22/1998
• Issued: 10/30/2001
• Est. Priority Date: 12/22/1998
• Status: Expired due to Term

• Current Assignee: University of Michigan
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Fowlkes, J. Brian, Cain, Charles A.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US09/218,310
• Time in Patent Office: 1,043 Days
• Field of Search: 604/22, 601/24, 607/97, 424/450, 424/9.5, 424/9.51, 424/9.52, 600/439
• US Class Current: 600/439
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2017/22089 Gas-bubbles
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2007/0039 using microbubbles
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method and assembly are provided which use cavitation induced by an ultrasound beam for creating a controlled surgical lesion in a selected treatment volume of a patient. First, a plurality of microbubbles are provided in the treatment volume. Preferably, the threshold for cavitation of microbubbles in the treatment volume is lowered compared with the threshold for cavitation in surrounding tissues. The expected location of the surgical lesion within the treatment volume may be previewed, and then the microbubbles in the treatment volume are cavitated with the ultrasound beam to create the controlled surgical lesion. Preferably, the creation of the surgical lesion at the expected lesion location is then verified. Using the method and assembly of the present invention, the cavitation threshold within the treatment volume is made predictable, and a low frequency ultrasound beam may be used to cavitate the microbubbles within the treatment volume without causing damage to surrounding tissues.

Claims

1. A method for creating a surgical lesion in a selected treatment volume of a patient, the method comprising:

providing a plurality of microbubbles in the treatment volume and in a volume external to the treatment volume, the microbubbles having a threshold for cavitation;

controlling the microbubbles in the external volume to create a differential threshold for cavitation between the external volume and the treatment volume; and

cavitating the plurality of microbubbles in the treatment volume with an ultrasound beam of sufficient energy at an appropriate frequency to create the surgical lesion in a controlled manner within the treatment volume.

2. The method of claim 1, wherein the frequency of the ultrasound beam is a low frequency.

3. The method of claim 1, further comprising lowering the threshold for cavitation of microbubbles in the treatment volume by producing a population of microbubbles within the treatment volume which have a limited size distribution, so that the microbubbles oscillate at a maximal response frequency.

4. The method of claim 3, wherein the maximal response frequency is a low frequency.

5. The method claim 1, wherein controlling the microbubbles in the external volume comprises eliminating microbubbles from the external volume with low intensity ultrasound beam.

6. The method of claim 1, wherein providing the plurality of microbubbles includes injecting the microbubbles into the patient systemically.

7. The method of claim 1, wherein providing the plurality of microbubbles includes injecting the microbubbles locally into the treatment volume.

8. The method of claim 1, wherein providing the plurality of microbubbles includes providing an admixture of microbubbles having populations with differing properties.

9. The method of claim 8, wherein providing an admixture of microbubbles includes providing a first population that responds primarily to high intensity ultrasound fields in combination with a second population that responds primarily to low intensity ultrasound fields.

10. The method of claim 1, wherein providing the plurality of microbubbles comprises creating the plurality of microbubbles with a preliminary ultrasound beam.

11. The method of claim 1, further comprising detecting the presence of microbubbles in the treatment volume.

12. The method of claim 11, wherein detecting the presence of microbubbles in the treatment volume uses harmonic imaging to determine the particular size distribution of microbubbles in the treatment volume.

13. The method of claim 1, further comprising previewing an expected location of the surgical lesion within the treatment volume.

14. The method of claim 13, wherein previewing the expected location of the surgical lesion includes directing a low intensity ultrasound beam at the treatment volume so as to collapse microbubbles at the focus of the beam, thereby indicating the expected lesion location.

15. The method of claim 13, wherein previewing the expected location of the surgical lesion includes briefly directing a high intensity ultrasound beam at the treatment volume to cause increased cavitation of the microbubbles, thereby indicating the expected lesion location.

16. The method of claim 1, wherein the ultrasound beam is focused.

17. The method of claim 1, wherein the ultrasound beam is unfocused.

18. The method of claim 1, wherein providing the plurality of microbubbles includes providing an admixture of microbubbles and drugs.

19. The method of claim 1, wherein cavitating the microbubbles releases drugs encapsulated therein within the treatment volume.

20. The method of claim 1, further comprising verifying the creation of the surgical lesion at an expected lesion location.

21. The method of claim 20, wherein verifying the creation of the surgical lesion includes providing new microbubbles in the treatment volume and monitoring the presence or absence thereof at the expected lesion location.

22. The method of claim 1, wherein controlling the microbubbles in the external volume includes reducing the cavitation potential in the external volume compared with the treatment volume.

23. A method for using cavitation induced by an ultrasound beam to create a controlled surgical lesion in a selected treatment volume of a patient, the method comprising:

providing a plurality of microbubbles in the treatment volume and in a volume external to the treatment volume, the microbubbles having a threshold for cavitation;

detecting the presence of microbubbles in the treatment volume;

controlling the microbubbles in the external volume to create a differential threshold for cavitation between the external volume and the treatment volume;

previewing an expected location of the surgical lesion within the treatment volume;

cavitating the microbubbles in the treatment volume with the ultrasound beam to create the controlled surgical lesion; and

verifying the creation of the surgical lesion at the expected lesion location.