Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
First Claim
1. A controlled release microcapsule phamaceutical formulation for burst-free, sustained, programmable release of a biologically active agent over a duration from 1-100 days, comprising an active agent encapsulated within a biodegradable poly(lactide/glycolide) having a lactide/glycolide ratio of 90/10 to 40/60 and the uncapped/end capped form of said poly(lactide/glycolide) in the ratio of 100/0 to 1/99, wherein the poly(lactide/glycolide) may contain a pharmaceutically-acceptable adjuvant.
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Accused Products
Abstract
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.
455 Citations
25 Claims
- 1. A controlled release microcapsule phamaceutical formulation for burst-free, sustained, programmable release of a biologically active agent over a duration from 1-100 days, comprising an active agent encapsulated within a biodegradable poly(lactide/glycolide) having a lactide/glycolide ratio of 90/10 to 40/60 and the uncapped/end capped form of said poly(lactide/glycolide) in the ratio of 100/0 to 1/99, wherein the poly(lactide/glycolide) may contain a pharmaceutically-acceptable adjuvant.
Specification