Anti-cancer therapy agent of arsenic hexoxide (As4O6) of a natural chemical substance and its pharmaceutical composition

• US 6,309,672 B1
• Filed: 06/26/1998
• Issued: 10/30/2001
• Est. Priority Date: 05/08/1998
• Status: Expired due to Term

• Current Assignee: Ill-Ju Bae, Ill-Jue Bae
• Original Assignee: Ill-Ju Bae
• Inventors: Lee, Kwan-Hee, Park, Choon-Ho, Song, Seung-Kyu, Suh, Byung-Sun, Song, Byung-Doo, Kang, Tae-Bong, Kwak, Jin-Hwan, Eun, Choong-Ki, Kim, Jong-Bae, Yoon, Taek-Joon, Bae, Ill-Ju, Doo, Myoung-Sool
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US09/105,086
• Time in Patent Office: 1,222 Days
• Field of Search: 424/623
• US Class Current: 424/623
• CPC Class Codes: A61K 33/36 Arsenic; Compounds thereof
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia

Abstract

This invention is about the identification of the HD-2, a natural chemical substance that was separated and purified from a natural product, Sinsuk, as arsenic hexoxide (As₄O₆) and about its therapeutic efficacy as an anti-cancer drug and pharmaceutical composition.

Arsenic hexoxide (As₄O₆), a natural chemical substance obtained from Sinsuk after eliminating the toxic property, has a potent anti-cancer efficacy by its direct cytotoxicity on tumor cells and suppresses the formation of new blood vessels of tumor masses, which results in complete cure of malignant cancers.

Claims

1. A method for treating cancer sensitive to AS₄O₆ comprising the step of administering to a patient in need thereof a pharmaceutical composition comprising a pharmaceutically effective amount of AS₄O₆ as an active ingredient and a pharmaceutically acceptable carrier.

2. The method of claim 1 wherein the cancer is a malignant cancer of the uterus.

3. The method of claim 1 wherein the cancer is a malignant cancer of the lung.

4. The method of claim 1 wherein the cancer is a malignant cancer of the maxillary sinus.

5. The method of claim 1 wherein the cancer is a malignant cancer of the kidney.

6. The method of claim 1 wherein the cancer is a malignant cancer of the urinary bladder.