Device for generating a pulsatile fluid drug flow

• US 6,312,409 B1
• Filed: 09/07/1999
• Issued: 11/06/2001
• Est. Priority Date: 12/31/1996
• Status: Expired due to Fees

• Current Assignee: Elan Pharma International Limited (Perrigo Company PLC)
• Original Assignee: Elan Corporation PLC (Perrigo Company PLC)
• Inventors: Gross, Joseph
• Primary Examiner(s): Seidel, Richard K.
• Assistant Examiner(s): HAYES, MICHAEL J
• Application Number:
  US09/331,648
• Time in Patent Office: 791 Days
• Field of Search: 604/131, 604/132, 604/134, 604/167-1-1, 604/246, 604/247, 604/249, 604/256, 601/148-150, 251/282, 251/331, 137/535
• US Class Current: 604/131
• CPC Class Codes: A61M 2206/10 Flow characteristics
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure

Abstract

A device (10) for generating a pulsatile fluid drug flow comprises a housing (11) containing an expandable-contractible chamber (12) having an inlet (14) and an outlet (15), a valve (16) associated with the outlet (15) which is actuated by the expansion and contraction of the chamber (12), and means (13, 23) for biasing the chamber (12) to its contracted state. When the inlet (14) is connected to a pressurised fluid drug supply the chamber (12) is expanded by the drug, and this expansion of the chamber (12) actuates the valve (16) to open, thereby allowing release of the drug from the chamber (12), following which the chamber (12) contracts under the influence of the biasing means (13, 23), this contraction in turn actuating the valve (16) to close thereby allowing the chamber (12) to refill. By this mechanism, a constant supply of liquid, such as from an osmotic or elastomeric drug delivery pump, can be converted to a pulsatile flow, which may provide a more suitable delivery of certain drugs.

Claims

1. A device for generating a pulsatile drug flow, comprising:

a housing containing an expandable/contractible chamber having an inlet and an outlet,

a valve, associated with the outlet, the valve being actuated by a bistable actuating member lied to the displacement member, the bistable actuating member acts on the valve to open and close the valve as tie bistable actuating member moves between its bistable configurations, and the valve being shaped to allow the bistable actuating member to undergo an initial deformation or movement without actuating the valve such that an actuation of the valve only occurs when the actuating member undergoes the full transition between its bistable configurations;

a displacement member that through its displacement controls the expansion and contraction of the chamber and the actuation of the valve; and

a resilient member for biasing the chamber to its contracted state such that when the inlet is connected to a pressurised fluid drug supply the chamber is expanded by the drug, the expansion of the chamber actuating the valve to open, thereby allowing a release of drug from the chamber and enabling the contraction of the chamber under the influence of the resilient member, this contraction in turn actuating the valve to close thereby allowing the chamber to refill.

2. A device according to claim 1, wherein said component of the valve is in the form of a longitudinally extending element having a section of lesser thickness intermediate two sections of greater thickness, and the bistable actuating member is provided with an aperture which moves freely with respect to the section of lesser thickness but which engages the sections of greater thickness.

3. A device according to claim 1 wherein the resilient member acts on a displaceble member which at least partially bounds the chamber such the expansion end contraction of the chamber occurs by the displacement of the displaceable member, and the outlet is formed by an aperture in the displaceable member, the aperture forming a seat for tho valve, and where the displaceable member is selected from a movable wall section, a diaphragm, a membrane and a bellows.

4. A device according to claim 3, wherein the valve comprises a blocking member which is adapted to move into and out of sealing engagement with the seat, thereby opening and closing said outlet.

5. A device according to claim 4, wherein the blocking member is carried on a second displaceable member and the aperture communicates with the exterior of the device via a gap between the displaceable members.

6. A device according to claim 5, wherein the second displaceable member is elastic and is biased to a position in which the blocking member is in sealing engagement with the aperture.

7. A device according to claim 1 which is adapted to be connected to and to receive a supply of fluid drug from a continuous flow drug pump.