Optical filter holder assembly

• US 6,313,960 B2
• Filed: 07/16/1998
• Issued: 11/06/2001
• Est. Priority Date: 07/16/1997
• Status: Expired due to Fees

• Current Assignee: Molecular Devices
• Original Assignee: LJL Biosystems, Inc. (Danaher Corporation)
• Inventors: Modlin, Douglas N., Granieri, Philip A. Jr., Wong, Calvin D., Edwards, Glenn R., Marquiss, Samuel A., Taylor, Michael T., El-Hage, Amer
• Primary Examiner(s): Chang, Audrey
• Application Number:
  US09/118,141
• Publication Number:
  US 20010021074A1
• Time in Patent Office: 1,209 Days
• Field of Search: 359/892, 359/885, 359/894, 359/819, 359/820, 359/827, 359/830, 359/500, 359/501, 359/502, 359/889, 362/294, 362/322, 362/324, 348/743
• US Class Current: 359/892
• CPC Class Codes: B01J 2219/00315 Microtiter plates
• CPC Class Codes: B01J 2219/00317 Microwell devices, i.e. having large numbers of wells
• CPC Class Codes: B01J 2219/00605 the compounds being directly bound or immobilised to solid supports
• CPC Class Codes: B01J 2219/0061 The surface being organic
• CPC Class Codes: B01J 2219/00612 the surface being inorganic
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00686 Automatic
• CPC Class Codes: B01J 2219/00691 using robots
• CPC Class Codes: B01J 2219/00707 separated from the reactor apparatus
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: C40B 60/14 for creating libraries
• CPC Class Codes: G01N 21/76 Chemiluminescence; Bioluminescence
• CPC Class Codes: Y10S 436/807 Apparatus included in process claim, e.g. physical support structures
• CPC Class Codes: Y10S 436/809 Multifield plates or multicontainer arrays
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/115831 Condition or time responsive
• CPC Class Codes: Y10T 436/25 : including sample preparation

Abstract

Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.

Claims

1. An optical filter wheel module comprising

an optical filter wheel that is rotatable around a rotational axis, and

a wheel case having a static portion and a removable portion, and at least one window for transmitting light through the wheel case and through a selected optical filter contained in the optical filter wheel, wherein the removable portion of the case carries the filter wheel, and is separable from the static portion of the case in a direction substantially perpendicular to the rotational axis so that the static portion of the case can remain fixed in relation to an optical axis while changing one or more filters in the filter wheel.

2. The module of claim 1, wherein the static portion has a pair of pins oriented generally perpendicular to the rotational axis, and the removable portion has a pair of holes for receiving the pins.

3. The module of claim 1, wherein the removable portion has a hub structure and the static portion has a cut-out for receiving the hub structure.

4. The module of claim 1, wherein static portion has two windows positioned on opposite sides of the rotational axis of the filter wheel, so that any given optical filter in the optical filter wheel can be rotated into alignment with either window.

5. The module of claim 1, wherein the filter wheel has multiple filter positions, the removable portion of the case being configured so that at least some of the filter positions are exposed when the removable portion is separated from the static portion.

6. The module of claim 1, wherein the wheel case is substantially light-tight, except for light that is transmitted through the window.

7. The module of claim 1, wherein the window is in the static portion of the wheel case.

8. The module of claim 1, wherein the window is in the removable portion of the wheel case.

9. The module of claim 1, wherein the static portion of the wheel case is fixed to an instrument platform.

10. The module of claim 1, further comprising a drive mechanism configured to rotate the optical filter wheel.

11. A light detection system comprising

an optical relay structure for directing light along an optical path to or from an examination site,

an optical filter wheel having plural filter holders radially positioned around a rotary axis, the rotary axis being substantially parallel to the optical path so that rotation of the filter wheel around the rotary axis permits different optical filters to be positioned in the optical path, and

a filter wheel handling member that permits the filter wheel to be removed from its operable position in the light detection system in a direction substantially perpendicular to the optical path, wherein the filter wheel handling member forms part of a filter wheel case, the filter wheel case having a lower portion that remains fixed relative to the optical path so that the filter wheel can be properly positioned relative to the optical path by engaging the handling member with the lower portion of the case.

12. A light detection system comprising an optical relay structure for directing light along an optical path to or from an examination site,

an optical filter wheel having plural filter holders radially positioned around a rotary axis, the rotary axis being substantially parallel to the optical path so that rotation of the filter wheel around the rotary axis permits different optical filters to be positioned in the optical path, and

a filter wheel case having an upper portion and a lower portion, the upper portion of the case holding an axle for rotating the filter wheel, the upper and lower portions being separable from each other in a direction perpendicular to the optical path.

13. The system of claim 12 further comprising a pin-in-hole engagement mechanism that aligns the upper and lower portions of the filter wheel case.

14. A filter wheel station for a light detection instrument comprising a registration structure that remains fixed in relation to an optical path and a rotary axis, a filter wheel,

a removable carrier member attached to the filter wheel, and

a mating device for engaging the carrier member and the fixed registration structure in a direction substantially perpendicular to the optical path.

15. The station of claim 14, wherein the fixed registration structure and the carrier member form a substantial housing around the filter wheel.

16. The station of claim 15, wherein the housing has at least one window for permitting transmission of light along the optical path and through a selected filter.

17. The station of claim 14, wherein the mating device includes a pair of pins and a pair of holes for receiving the pins.

18. The station of claim 17, wherein the pins are formed in the registration device, and the holes are located in the carrier member.