Electroactive pore
First Claim
Patent Images
1. A device, comprising:
- a member having a pore passing therethrough;
an electroactive polymer disposed so that when the electroactive polymer has a first state of charge a therapeutic agent has a first ability to pass through the pore, and when the electroactive pore has a second state of charge different from the first state of charge the therapeutic agent has a second ability to pass through the pore different than the first ability to pass through the pore; and
a BETA associated with the electroactive polymer, wherein the electroactive polymer is at least partially disposed within the pore.
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Abstract
Electroactive pores, devices including one or more electroactive pores are described, and methods of delivering therapeutic agents using one or more electroactive pores are described.
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Citations
62 Claims
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1. A device, comprising:
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a member having a pore passing therethrough;
an electroactive polymer disposed so that when the electroactive polymer has a first state of charge a therapeutic agent has a first ability to pass through the pore, and when the electroactive pore has a second state of charge different from the first state of charge the therapeutic agent has a second ability to pass through the pore different than the first ability to pass through the pore; and
a BETA associated with the electroactive polymer, wherein the electroactive polymer is at least partially disposed within the pore. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A device, comprising:
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a member having a pore passing therethrough;
an electroactive polymer disposed so that when the electroactive polymer has a first state of charge a therapeutic agent has a first ability to pass through the pore, and when the electroactive pore has a second state of charge different from the first state of charge the therapeutic agent has a second ability to pass through the pore different than the first ability to pass through the pore; and
a BETA associated with the electroactive polymer, wherein the BETA comprises glucose oxidase. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A device, comprising:
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a member having a pore passing therethrough;
an electroactive polymer disposed so that when the electroactive polymer has a first state of charge a therapeutic agent has a first ability to pass through the pore, and when the electroactive pore has a second state of charge different from the first state of charge the therapeutic agent has a second ability to pass through the pore different than the first ability to pass through the pore;
a BETA associated with the electroactive polymer; and
a mediator that mediates charge transfer between the electroactive pore and the member. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A device, comprising:
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a member having a pore passing therethrough;
an electroactive polymer disposed so that when the electroactive polymer has a first state of charge a therapeutic agent has a first ability to pass through the pore, and when the electroactive pore has a second state of charge different from the first state of charge the therapeutic agent has a second ability to pass through the pore different than the first ability to pass through the pore;
a BETA associated with the electroactive polymer; and
a mediator that mediates charge transfer between the electroactive pore and an analyte. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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54. A device, comprising:
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a member having a pore passing therethrough;
an electroactive polymer disposed so that when the electroactive polymer has a first state of charge a therapeutic agent has a first ability to pass through the pore, and when the electroactive pore has a second state of charge different from the first state of charge the therapeutic agent has a second ability to pass through the pore different than the first ability to pass through the pore; and
a BETA associated with the electroactive polymer, wherein the electroactive polymer comprises a polymer comprising a component selected from the group consisting of thiophen, derivatives of thiopen, phenylene, derivatives of phenylene, diamine, derivatives of diamine, pyrrole, derivatives of pyrrole, aniline, derivatives of aniline, and combinations thereof, and the BETA comprises glucose oxidase. - View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62)
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Specification