System and method for high pressure delivery of gas-supersaturated fluids

• US 6,315,754 B1
• Filed: 12/21/1999
• Issued: 11/13/2001
• Est. Priority Date: 08/15/1997
• Status: Expired due to Term

• Current Assignee: TherOx Incorporated (Asahi Kasei Corporation)
• Original Assignee: TherOx Incorporated (Asahi Kasei Corporation)
• Inventors: Gessert, James M., Daoud, Adib G.
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US09/467,673
• Time in Patent Office: 693 Days
• Field of Search: 604/154, 604/152, 604/65-67, 604/23-26, 604/131, 604/151, 604/264, 604/21, 604/28, 604/500, 128/DIG.1, 128/12, 128/13
• US Class Current: 604/23
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions

Abstract

A system and method for generating a gas-supersaturated fluid and delivering the fluid at high delivery pressures to thereby prevent bubble nucleation is disclosed. The system comprises a housing for containing a removable fluid assembly for housing a fluid to be gas-supersaturated and a drive assembly for delivering the fluid to a delivery site. The housing assembly comprises a cylinder and a piston which may be advanced along the inner surface of the cylinder to pressurize and to deliver the fluid. To generate a gas-supersaturated fluid, the housing assembly is removed from the system housing, filled with a fluid, and gas is introduced at or slightly above the desired gas partial pressure into the cylinder. To deliver the gas-supersaturated fluid, the fluid assembly is returned to the system housing and the drive assembly advances the piston to increase the hydrostatic pressure to the desired delivery pressure and, after opening a valve, to deliver the gas-supersaturated fluid at the desired high delivery pressure to a delivery site.

Claims

1. A container for a pressurized fluid comprising:

a receptacle;

a piston disposed within the receptacle, the piston comprising;

a seal adapted to seal the piston within the receptacle;

a port extending through the piston; and

a valve operatively arranged relative to the port to permit introduction of the fluid into the receptacle.

2. The container, as set forth in claim 1, wherein the valve comprises a check valve, the check valve having a valve seat, a ball, and a spring, the spring biasing the ball toward the valve seat.

3. The container, as set forth in claim 2, wherein the piston comprises an actuator being moveable in a first direction to move the ball away from the valve seat and being moveable in a second direction to move the ball into contact with the valve seat.

4. The container, as set forth in claim 3, wherein the fluid may be introduced into the receptacle through the piston when the actuator moves the ball in the first direction.

5. The container, as set forth in claim 2, wherein the fluid may be introduced into the receptacle through the piston when the fluid overcomes the force of the spring to move the ball away from the valve seat.

6. The container, as set forth in claim 1, wherein the port is adapted to accept a cannula for the introduction of the fluid into the receptacle.

7. The container, as set forth in claim 1, wherein the receptacle comprises a retainer which retains the piston within the receptacle.

8. The container, as set forth in claim 2, wherein the check valve prevents the fluid from escaping from the receptacle.

9. The container, as set forth in claim 1, wherein the seal comprises a high pressure seal disposed about a peripheral portion of the piston.

10. The container, as set forth in claim 7, wherein the retainer comprises a piston cap.

11. The container, as set forth in claim 1, wherein the piston comprises a threaded annular recess.

12. The container, as set forth in claim 11, comprising a piston handle adapted to thread to the threaded annular recess of the piston.