Cell storage maintenance and monitoring system
First Claim
1. A method for monitoring the quality of a blood product stored in flexible bag comprising the steps of:
- separating the bag into a first volume and a second volume with a membrane having a plurality of pores selectively containing an erodible substance, the blood product being stored within the second volume;
eroding the erodible substance contained within the pores in response to a selected characteristic of the blood product;
detecting changes in the quality of the blood product in response to the erosion of the erodible substance;
wherein the step of detecting changes in the quality of the blood product comprises detecting changes in glucose levels of the blood product.
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Accused Products
Abstract
A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a characteristic of the blood product, such as pH. When the pH value drops to a predetermined level, the substance begins to erode, causing the pores to enlarge, and allowing a portion of the blood product to pass through the pores into the contained space, where it can be visibly detected. The contained space may contain a chemical indicator or buffers and nutrients, which are released into the blood product when the pores begin to open. In another embodiment, the microporous membrane may be in the form of a pod or capsule which may be attached to the wall or allowed to free-float within the contents of the storage container.
64 Citations
3 Claims
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1. A method for monitoring the quality of a blood product stored in flexible bag comprising the steps of:
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separating the bag into a first volume and a second volume with a membrane having a plurality of pores selectively containing an erodible substance, the blood product being stored within the second volume;
eroding the erodible substance contained within the pores in response to a selected characteristic of the blood product;
detecting changes in the quality of the blood product in response to the erosion of the erodible substance;
wherein the step of detecting changes in the quality of the blood product comprises detecting changes in glucose levels of the blood product. - View Dependent Claims (2)
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3. A method for monitoring the quality of a blood product stored in a flexible bag comprising the steps of:
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separating the bag into a first volume and a second volume with a membrane having a plurality of pores selectively containing an erodible substance, the blood product being stored within the second volume;
eroding the erodible substance contained within the pores in response to a selected characteristic of the blood product;
detecting changes in the quality of the blood product in response to the erosion of the erodible substance;
adding a selected chemical agent to the first volume in the bag, the agent being in passive communication with the blood product in the second volume through the pores;
passing a portion of at least one of the blood product or the chemical agent through the eroded pores;
wherein the step of detecting changes in the quality of the blood product further comprises detecting changes in response to the passage of a portion of at least one of the blood product or chemical agent through the pores; and
wherein the step of adding a selected chemical agent comprises adding a selected chemical agent selected from the group consisting of sodium bicarbonate, sodium phosphate, sodium acetate, fatty acids, phosphate or acetate.
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Specification