Dual-stage hemodiafiltration cartridge
First Claim
1. A dual-stage hemodiafiltration cartridge comprising:
- a first hemodiafiltration stage including a first housing having first and second ends and first filtering elements disposed between the first and second ends, the first end being associated with a blood inlet which allows flow of blood into a blood-side of said first filtering elements and a first dialysate outlet which allows flow of dialysate out of a dialysate-side of said first filtering elements and the second end being associated with a first dialysate inlet which allows flow of dialysate into a dialysate-side of said first filtering elements;
a second hemodiafiltration stage including a second housing having third and fourth ends and second filtering elements disposed between the third and fourth ends, the fourth end being associated with a blood outlet which allows flow of blood out of a blood-side of said second filtering elements and a second dialysate inlet which allows flow of dialysate into a dialysate-side of said second filtering elements and the third end being associated with a second dialysate outlet which allows flow of dialysate out of the dialysate-side of said second filtering elements; and
an inter-stage connector connected to the second end of the first housing and to the third end of the second housing and adapted to allow flow of blood from the blood side of the first filtering elements to the blood-side of the second filtering elements and flow of dialysate fluid therethrough from the second stage to the first stage, wherein said inter-stage connector has a header space in communication with the blood-side of the first filtering elements and with the blood-side of the second filtering elements, the inter-stage connector having a substitution-fluid inlet which allows flow of substitution fluid into said header space thereby to dilute the blood in said header space.
7 Assignments
0 Petitions
Accused Products
Abstract
A dual-stage hemodiafiltration cartridge is presented and includes a first hemodiafiltration stage including a first housing with first filtering elements disposed therein. The first housing has a blood inlet and a first dialysate outlet at one end and a first dialysate inlet at an opposite end. The cartridge further includes a second hemodiafiltration stage having a second housing with second filtering elements disposed therein. One end of the second housing has a blood outlet and a second dialysate inlet. An opposite end has a second dialysate outlet. An inter-stage connector is connected to one end of the first housing and to one end of the second housing and is adapted to allow flow of blood from a blood side of said first filtering elements to a blood-side of the second filtering elements and flow of dialysate fluid therethrough from the second stage to the first stage.
128 Citations
19 Claims
-
1. A dual-stage hemodiafiltration cartridge comprising:
-
a first hemodiafiltration stage including a first housing having first and second ends and first filtering elements disposed between the first and second ends, the first end being associated with a blood inlet which allows flow of blood into a blood-side of said first filtering elements and a first dialysate outlet which allows flow of dialysate out of a dialysate-side of said first filtering elements and the second end being associated with a first dialysate inlet which allows flow of dialysate into a dialysate-side of said first filtering elements;
a second hemodiafiltration stage including a second housing having third and fourth ends and second filtering elements disposed between the third and fourth ends, the fourth end being associated with a blood outlet which allows flow of blood out of a blood-side of said second filtering elements and a second dialysate inlet which allows flow of dialysate into a dialysate-side of said second filtering elements and the third end being associated with a second dialysate outlet which allows flow of dialysate out of the dialysate-side of said second filtering elements; and
an inter-stage connector connected to the second end of the first housing and to the third end of the second housing and adapted to allow flow of blood from the blood side of the first filtering elements to the blood-side of the second filtering elements and flow of dialysate fluid therethrough from the second stage to the first stage, wherein said inter-stage connector has a header space in communication with the blood-side of the first filtering elements and with the blood-side of the second filtering elements, the inter-stage connector having a substitution-fluid inlet which allows flow of substitution fluid into said header space thereby to dilute the blood in said header space. - View Dependent Claims (2, 4, 5)
a dual-stage hemodiafiltration cartridge according to claim 1; and
a control mechanism adapted to receive dialysate from the second dialysate outlet and to supply dialysate to the first dialysate inlet, wherein said control mechanism controls the relative toxin removal rates of said first and second hemodiafiltration stages.
-
-
5. A dual-stage hemodiafiltration cartridge according to claim 1, wherein said first and second housings are arranged parallel to one another with said first end spaced proximately from said fourth end such that the blood flows in a first direction in said first stage and in a second direction in said second stage, said first direction being opposite to said second direction.
-
3. A dual-stage hemodiafiltration cartridge comprising:
-
a first hemodiafiltration stage including a first housing having first and second ends and first filtering elements disposed between the first and second ends, the first end being associated with a blood inlet which allows flow of blood into a blood-side of said first filtering elements and a first dialysate outlet which allows flow of dialysate out of a dialysate-side of said first filtering elements and the second end being associated with a first dialysate inlet which allows flow of dialysate into a dialysate-side of said first filtering elements;
a second hemodiafiltration stage including a second housing having third and fourth ends and second filtering elements disposed between the third and fourth ends, the fourth end being associated with a blood outlet which allows flow of blood out of a blood-side of said second filtering elements and a second dialysate inlet which allows flow of dialysate into a dialysate-side of said second filtering elements and the third end being associated with a second dialysate outlet which allows flow of dialysate out of the dialysate-side of said second filtering elements; and
an inter-stage connector connected the second end of the first housing and to the third end of the second housing and adapted to allow flow of blood from the blood side of the first filtering elements to the blood-side of the second filtering elements, wherein said inter-stage connector has a header space in communication with the blood-side of the first filtering elements and with the blood-side of the second filtering elements, the inter-stage connector having a substitution-fluid inlet which allows flow of substitution fluid into said header space thereby to dilute the blood in said header space, the inter-stage connector comprising an inter-dialysate port including said first dialysate inlet and said second dialysate outlet, the cartridge including an inter-aperture cap mounted on said inter-dialysate port and structured to allow flow of dialysate directly from the second dialysate outlet to the first dialysate inlet.
-
-
6. A dual-stage hemodiafiltration cartridge comprising:
-
a first hemodiafiltration stage including a first housing having first and second ends;
at least one first filtering element disposed between said first and second ends of said first housing, said first end having a blood inlet which communicates with a blood-side of said at least one first filtering element and a first dialysate outlet which is in fluid communication with a dialysate-side of said at least one first filtering element, said second end of said first housing having a first dialysate inlet which admits dialysate into said dialysate-side of said at least one first filtering element;
a second hemodiafiltration stage including a second housing having third and fourth ends;
at least one second filtering element disposed between said third and fourth ends of said second housing, said fourth end having a blood outlet for passage of blood out of a blood-side of said at least one second filtering element and a second dialysate inlet which is in fluid communication with a dialysate-side of said at least one second filtering element, said third end having a second dialysate outlet for discharge of dialysate from said dialysate-side of said at least one second filtering element; and
a connector connected to said second end of said first housing and to said third end of said second housing for the passage of blood from the blood-side of said at least one first filtering element to the blood-side of said at least one second filtering element, said connector having a fluid inlet for receiving substitution fluid which mixes with the blood from said first stage before the blood flows to said blood-side of said at least one second filtering element of said second stage, said connector adapted to conduct the dialysate from said second stage to said first stage. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13)
an inter-stage header cap releasably mounted to said connector, said cap having an inlet for receiving substitution fluid.
-
-
10. A dual-stage hemodiafiltration cartridge according to claim 9, further including:
a sealing member for sealing said header space from an external environment, said sealing member being disposed between said inter-stage header cap and said connector, thereby sealing said header space.
-
11. A dual-stage hemodiafiltration cartridge according to claim 6, wherein said connector includes an inter-dialysate port defined at least in part by said first dialysate inlet and said second dialysate outlet, said inter-dialysate port permitting the dialysate to flow from said second stage to said first stage.
-
12. A dual-stage hemodiafiltration cartridge according to claim 11, further including an inter-aperture cap detachably coupled to said inter-dialysate port and configured to permit the dialysate to flow from said second dialysate outlet to said first dialysate inlet.
-
13. A dual-stage hemodiafiltration cartridge according to claim 8, wherein said connector includes a member for separating said first and second stages, said member partitioning said header space from said first and second stages, said member communicating with said at least one first and second filtering elements such that said blood-sides of said at least one first and second filtering elements are in fluid communication with said header space to permit the blood to flow from said at least one first filtering element through said header space to said at least one second filtering element.
-
14. A dual-stage hemodiafiltration cartridge comprising:
-
a first hemodiafiltration stage including a first housing having first and second ends;
at least one first filtering element disposed between said first and second ends of said first housing, said first end having a blood inlet which communicates with a first side of said at least one first filtering element and a first dialysate outlet which is in fluid communication with a second side of said at least one first filtering element, said second end of said housing having a first dialysate inlet which admits dialysate into said second side of said at least one first filtering element;
a second hemodiafiltration stage including a second housing having third and fourth ends;
at least one second filtering element disposed between said third and fourth ends of said second housing, said fourth end having a blood outlet for passage of blood out of a first side of said at least one second filtering element and a second dialysate inlet which is in fluid communication with a second side of said at least one second filtering element, said third end having a second dialysate outlet for discharge of dialysate from said second side of said at least one second filtering element; and
a connector connected to said second end of said first housing and to said third end of said second housing for the passage of blood from the first side of said at least one first filtering element to the first side of said at least one second filtering element, said connector being in fluid communication with the second sides of said at least one first and second filtering elements for passage of dialysate fluid from said second stage to said first stage. - View Dependent Claims (15, 16, 17)
-
-
18. A dual-stage hemodiafiltration cartridge comprising:
-
a first hemodiafiltration stage including a first housing having first and second ends;
at least one first filtering element disposed between said first and second ends of said first housing, said first end having a blood inlet which communicates with a first surface of said at least one first filtering element and a first dialysate outlet which is in fluid communication with a second surface of said at least one first filtering element, said second end of said housing having a first dialysate inlet which admits dialysate to said second surface of said at least one first filtering element;
a second hemodiafiltration stage including a second housing having third and fourth ends;
at least one second filtering element disposed between said third and fourth ends of said second housing, said fourth end having a blood outlet for passage of blood from a first surface of said at least one second filtering element and a second dialysate inlet which admits dialysate to a second surface of said at least one second filtering element, said third end having a second dialysate outlet for discharge of dialysate from said second surface of said at least one second filtering element; and
a connector connected to the second end of said first housing and to said third end of said second housing, said connector including a first section for the passage of blood from the first surface of said at least one first filtering element to the first surface of said at least one second filtering element and a second section for passage of dialysate fluid from said second stage to said first stage. - View Dependent Claims (19)
-
Specification