Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures

• US 6,316,022 B1
• Filed: 12/26/1995
• Issued: 11/13/2001
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Noven Pharmaceuticals Inc (Hisamitsu Pharmaceutical Company Incorporated)
• Original Assignee: Noven Pharmaceuticals Inc (Hisamitsu Pharmaceutical Company Incorporated)
• Inventors: Houze, David, Mantelle, Juan
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US08/578,308
• Time in Patent Office: 2,149 Days
• Field of Search: 424/448, 424/449, 424/486, 424/78.02, 424/487
• US Class Current: 424/448
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61K 9/7069 obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 39/02 Antidotes

Abstract

A transdermal composition is disclosed which contains a blend of one or more polymers, one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures. The composition is substantially free of water and liquids which have a normal boiling point (a) optionally below processing temperatures and (b) greater than or equal to the temperature of the low molecular weight drugs. The composition does not suffer from the substantial loss of the lower molecular weight drug during production of the transdermal system. A transdermal composition is also disclosed which has one or more drugs, at least one of which has a low molecular weight and is liquid at or about room temperatures, and a polymer matrix including one or more high shear resistant polymers. The high shear resistant polymer(s) reduce the plasticizing effect of the low molecular weight drug, and has sufficient tack and shear for application to a human being.

Claims

1. A pressure-sensitive adhesive transdermal drug delivery system suitable for transdermal drug delivery comprising a blend of:

(a) one or more solvent-based high shear resistant acrylic-based polymers having a shear resistance which is greater than or equal to 50 hours at 8 pounds per square inch and 72°

Fahrenheit; and

(b) a therapeutically effective amount of one or more drugs, at least one of which is of low molecular weight and liquid at or about room temperatures, wherein the one or more drugs excludes nicotine and wherein the transdermal drug delivery system forms a polymer matrix which has sufficient tack and shear to remain in place under conditions of use.

2. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, wherein the one or ore drugs are present in a range of 1 to 40 weight per cent, based on the dry weight of the total transdermal system.

3. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, wherein the one or more high shear resistant acrylic-based polymers have a weight average molecular weight in the range of about 600,000 to about 1,000,000 daltons.

4. A pressure-sensitive transdermal drug delivery system as claimed in claim 3, wherein the one or more high shear resistant acrylic-based polymers have a weight average molecular weight in the range of about 700,000 to about 900,000 daltons.

5. A pressure-sensitive transdermal drug delivery system as claimed in claim 4, wherein the one or more high shear resistant acrylic-based polymers have a weight average molecular weight in the range of about 750,000 to about 850,000 daltons.

6. A pressure-sensitive transdermal drug delivery system for transdermal drug delivery as claimed in claim 1, wherein the one or more drugs comprise selegiline, nitroglycerin, nicotine, ciclopirox olamine, tolbuterol, propanolol, bupranolol, arecolin, methamphetamin, ethosuximide, melproic acid, prilocaine, dyclonine, valproic acid and amphetaminil.

7. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, wherein the one or more acrylic-based polymers comprise a pressure-sensitive adhesive.

8. A pressure-sensitive transdermal drug delivery system as claimed in claim 7, wherein the one or more high shear resistant, acrylic-based polymers are present in the system in a range of about 10-90 weight per cent, based on the dry weight of the total transdermal system.

9. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, further comprising a backing material superimposed on one surface of the blend, the backing material being substantially impermeable to the drug contained therein.

10. A pressure-sensitive transdermal drug delivery system as claimed in claim 9, further comprising a release liner superimposed on a surface of the blend opposite the backing material.

11. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, wherein the one or more drugs comprise selegiline and at least one other drug.

12. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, wherein the system further comprises an additive selected from one or more of a filler, an enhancer and an excipient.

13. A pressure-sensitive transdermal drug delivery system as claimed in claim 6, wherein the one or more drugs are present in their free-base or free-acid form.

16. A pressure-sensitive transdermal drug delivery system as claimed in claim 1, wherein the one or more high shear resistant acrylic-based polymers have a shear resistance which is greater than or equal to 100 hours at 4 pounds per square inch and 72°

Fahrenheit.

17. A pressure-sensitive transdermal drug delivery system as claimed in claim 16, wherein the one or more high shear resistant acrylic-based polymers have a shear resistance which is greater than or equal to 100 hours at 8 pounds per square inch and 72°

Fahrenheit.

18. A pressure-sensitive transdermal drug delivery system as claimed in claim 11, wherein the delivery of selegiline from the system through intact skin in humans ranges between 0.1 and 2.5 mg/cm²/day.

19. A pressure-sensitive transdermal drug delivery system as claimed in claim 6, wherein the one or more drugs comprise nitroglycerin.

20. A pressure-sensitive transdermal drug delivery system as claimed in claim 19, wherein the delivery of nitroglycerine from the system through intact skin in humans ranges between 0.05 and 2.5 mg/cm²/day.

22. A pressure-sensitive adhesive transdermal drug delivery system as claimed in claim 1, wherein the one or more drugs include selegiline.

14. A method of producing a pressure-sensitive transdermal drug delivery system suitable for a transdermal drug delivery system, comprising the steps of:

(1) producing a blend of;

(a) one or more solvent-based high shear resistant acrylic-based polymers having a shear resistance of greater than or equal to 50 hours at 8 pounds per square inch and 72°

Fahrenheit and mixtures thereof; and

(b) a therapeutically effective amount of one or more drugs, at least one of which is of low molecular weight and liquid at or about room temperatures, wherein the one or more drugs excludes nicotine and wherein the blend is in a solvent system;

(2) forming the blend into a polymer matrix; and

(3) drying the polymer matrix to remove the solvent system to form the transdermal drug delivery system, wherein the system forms a polymer matrix which has sufficient tack and shear for application to a human being.

15. A method as claimed in claim 14 wherein the high shear resistant polymer comprises a high molecular weight pressure-sensitive acrylic-based polymer.

21. A pressure-sensitive transdermal drug delivery system as claimed 1, wherein the system is substantially free of water and liquids having a normal boiling point below processing temperatures and also about equal to or greater than the normal boiling points of the one or more low molecular weight drugs.

23. A pressure-sensitive adhesive transdermal drug delivery system suitable for transdermal drug delivery comprising a blend of:

(a) a pressure-sensitive adhesive polymer which consist of one or more solvent-based high shear resistant acrylic-based polymers having a shear resistance which is greater than or equal to 50 hours at 4 pounds per square inch and 72°

Fahrenheit; and

(b) a therapeutically effective amount of one or more drugs, at least one of which is of low molecular weight and liquid at or about room temperatures, wherein the one or more drugs excludes nicotine and wherein the transdermal drug delivery system forms a polymer matrix which has sufficient tack and shear to remain in place under conditions of use.

25. A pressure-sensitive adhesive transdermal drug delivery system as claimed in claim 23, wherein the one or more solvent-based high shear resistant acrylic-based polymers have a shear resistance which is greater than or equal to 50 hours at 8 pounds per square inch and 72°

Fahrenheit.

26. A pressure-sensitive adhesive transdermal drug delivery system as claimed in claim 23, wherein the one or more drugs include selegiline.

24. A method of producing a pressure-sensitive transdermal drug delivery system suitable for a transdermal drug delivery system, comprising the steps of:

(1) producing a blend of;

(a) a pressure-sensitive adhesive polymer which consist of one or more solvent-based high shear resistant acrylic-based polymers having a shear resistance of greater than or equal to 50 hours at 4 pounds per square inch and 72°

Fahrenheit and mixtures thereof; and

(b) a therapeutically effective amount of one or more drugs, at least one of which is of low molecular weight and liquid at or about room temperatures, wherein the one or more drugs excludes nicotine and wherein the blend is in a solvent system;

(2) forming the blend into a polymer matrix; and

(3) drying the polymer matrix to remove the solvent system to form the transdermal drug delivery system, wherein the system forms a polymer matrix which has sufficient tack and shear for application to a human being.