Therapeutic liposome composition and method of preparation
First Claim
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1. A method of formulating a therapeutic liposome composition having sensitivity to a target cell, comprisingselecting a liposome composition from a plurality of liposomal compositions comprised of pre-formed liposomes having an entrapped therapeutic agent;
- selecting from a plurality of targeting conjugates a targeting conjugate comprised of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer; and
combining the selected liposome composition and the selected targeting conjugate to form a therapeutic target-cell sensitive liposome composition.
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Abstract
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
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25 Claims
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1. A method of formulating a therapeutic liposome composition having sensitivity to a target cell, comprising
selecting a liposome composition from a plurality of liposomal compositions comprised of pre-formed liposomes having an entrapped therapeutic agent; -
selecting from a plurality of targeting conjugates a targeting conjugate comprised of (i) a lipid having a polar head group and a hydrophobic tail, (ii) a hydrophilic polymer having a proximal end and a distal end, said polymer attached at its proximal end to the head group of the lipid, and (iii) a targeting ligand attached to the distal end of the polymer; and
combining the selected liposome composition and the selected targeting conjugate to form a therapeutic target-cell sensitive liposome composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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