Multi-imaging modality tissue mimicking materials for imaging phantoms

• US 6,318,146 B1
• Filed: 07/14/1999
• Issued: 11/20/2001
• Est. Priority Date: 07/14/1999
• Status: Expired due to Term

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Frank, Gary R., Madsen, Ernest L., DʼSouza, Warren D.
• Primary Examiner(s): Kwok, Helen
• Assistant Examiner(s): GARBER, CHARLES D
• Application Number:
  US09/353,752
• Time in Patent Office: 860 Days
• Field of Search: 73/18.6, 738/662.1, 73/18.2, 436/8, 324/308, 324/309
• US Class Current: 73/1.86
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/587 Calibration phantoms models for medical purposes G09B23/28
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Tissue-mimicking material suitable for phantoms for use with at least ultrasound and MRI have sections of material in contact with each other which mimic ultrasound and magnetic resonance imaging properties of human tissues, and preferably also computed tomography properties, so that the phantom can be used for the testing of imaging by various types of medical imagers. A suitable tissue-mimicking material for use in phantoms of this type includes an aqueous mixture of large organic water soluble molecules, a copper salt, a chelating agent for binding the copper ions in the salt, and a gel-forming material. Small glass beads may be intermixed therewith to provide a selected ultrasound attenuation coefficient without substantially affecting the MRI properties of the material. Larger glass beads may be used in a section to control primarily the ultrasound backscatter coefficient without significant effect on the ultrasound attenuation coefficient. Tissue-mimicking material that simulates muscle may have smaller glass beads and a higher concentration of gel-forming material than an adjacent section. Such similar materials in contact with one another show relative stability over extended periods of time.

Claims

1. Multi-imaging modality tissue-mimicking material for phantoms for use with at least ultrasound and MRI comprising:

an aqueous mixture of large organic water soluble molecules, a copper salt, a chelating agent for binding the copper ions in the salt, a gel-forming material, and beads intermixed therewith to provide a selected ultrasound attenuation coefficient, the beads treated to have a low effect on the MRI T1 and T2 properties of the tissue-mimicking material.

2. The tissue-mimicking material of claim 1 wherein the gel-forming agent is agarose.

3. The tissue-mimicking material of claim 1 wherein the copper salt is CuCl₂.

4. The tissue-mimicking material of claim 1 wherein the large organic water soluble molecules are derived from condensed milk.

5. The tissue-mimicking material of claim 1 further including n-propyl alcohol intermixed therewith.

6. The tissue-mimicking material of claim 1 wherein the chelating agent is EDTA.

7. The tissue-mimicking material of claim 1 further comprising thimerosal intermixed therewith as a preservative.

8. The tissue-mimicking material of claim 1 wherein the beads are selected from glass beads that have been treated by a soak in nitric acid to clean the surface thereof to reduce the effect of the glass beads on MRI T1 and T2 properties.

9. Multi-imaging modality tissue-mimicking material for phantoms for use with at least ultrasound and MRI comprising:

an aqueous mixture of large organic water soluble molecules, CuCl₂ salt, EDTA as a chelating agent for binding the copper ions in the salt, and a gel-forming material, and glass beads of two different diameters intermixed therewith to provide a selected ultrasound attenuation coefficient and backscatter coefficient, the glass beads selected to have a low effect on the MRI T1 and T2 properties of the tissue-mimicking material.

10. The tissue-mimicking material of claim 9 wherein the glass beads are selected from glass beads that have been treated by a soak in nitric acid to clean the surface thereof to reduce the effect of the glass beads on MRI T1 and T2 properties.

11. The tissue-mimicking material of claim 9 wherein the first, small diameter glass beads have a mean diameter of about 20 μ

m or less to influence primarily ultrasound and CT attenuation, and the second, large diameter glass beads have a mean diameter of 30 μ

m or larger to influence primarily ultrasound backscatter.

12. The tissue-mimicking material of claim 9 wherein the gel-forming agent is agarose.

13. The tissue-mimicking material of claim 9 wherein the large organic water soluble molecules are derived from condensed milk.

14. The tissue-mimicking material of claim 9 further including n-propyl alcohol intermixed therewith.

15. The tissue-mimicking material of claim 9 further comprising thimerosal intermixed therewith as a preservative.

16. An imaging phantom for use with at least ultrasound and MRI comprising:

(a) a phantom container;

(b) a tissue-mimicking material within the container, the tissue-mimicking material comprising at least two distinct sections in contact with each other, the two sections having first, small diameter glass beads intermixed therewith to provide a selected ultrasound attenuation coefficient therein, and wherein one of the sections includes second, larger diameter beads intermixed therewith to provide a selected backscatter coefficient therein.

17. The imaging phantom of claim 16 wherein the tissue-mimicking material in at least two sections in contact with each other includes an aqueous mixture of large organic water soluble molecules, a copper salt, a chelating agent for bonding the copper ions in the salt, and a gel-forming material.

18. The imaging phantom of claim 17 wherein the gel-forming agent is agarose.

19. The imaging phantom of claim 18 wherein the section having larger glass beads therein has a higher dry weight concentration of agarose than the other section.

20. The imaging phantom of claim 17 wherein the copper salt is CuCl₂.

21. The imaging phantom of claim 17 wherein the large organic water soluble molecules are derived from condensed milk.

22. The imaging phantom of claim 17 further including n-propyl alcohol intermixed therewith.

23. The imaging phantom of claim 17 wherein the chelating agent is EDTA.

24. The imaging phantom of claim 17 further comprising thimerosal intermixed therewith as a preservative.

25. The imaging phantom of claim 16 wherein the beads are selected from glass beads that have been treated by a soak in nitric acid to clean the surface thereof to reduce the effect of the glass beads on MRI T1 and T2 properties.

26. The imaging phantom of claim 16 further including a section of tissue-mimicking material including vegetable oil to simulate fat tissue.

27. The imaging phantom of claim 16 wherein the first, small diameter beads have a mean diameter of about 20 μ

m or less to influence primarily ultrasound and CT attenuation, and the second, large diameter beads have a mean diameter of 30 μ

m or greater to influence primarily ultrasound backscatter.

28. The imaging phantom of claim 16 including a third section comprising a polyurethane mesh with interstices filled with oil.

29. The imaging phantom of claim 28 wherein the oil is vegetable oil.

30. An imaging phantom for use with at least ultrasound and MRI comprising:

(a) a phantom container;

(b) a tissue-mimicking material within the container, the tissue-mimicking material comprising at least three distinct sections in contact with each other, the tissue-mimicking material in a first and second section in contact with each other including an aqueous mixture of large organic water soluble molecules, a copper salt, a chelating agent for bonding the copper ions in the salt, and a gel-forming material, the two sections having first, small diameter beads intermixed therewith to provide a selected ultrasound attenuation coefficient therein, and wherein one of the sections includes second, larger diameter beads intermixed therewith to provide a selected backscatter coefficient therein, the glass beads treated to have a low effect on the MRI T1 and T2 properties.

31. The imaging phantom of claim 30 wherein the gel-forming agent is agarose.

32. The imaging phantom of claim 31 wherein the section having larger beads therein has a higher dry weight concentration of agarose than the other section.

33. The imaging phantom of claim 30 wherein the copper salt is CuCl₂.

34. The imaging phantom of claim 30 wherein the large organic water soluble molecules are derived from condensed milk.

35. The imaging phantom of claim 30 further including n-propyl alcohol intermixed therewith.

36. The imaging phantom of claim 30 wherein the chelating agent is EDTA.

37. The imaging phantom of claim 30 further comprising thimerosal intermixed therewith as a preservative.

38. The imaging phantom of claim 30 wherein the beads are selected from glass beads that have been treated by a soak in nitric acid to clean the surface thereof to reduce the effect of the glass beads on MRI T1 and T2 properties.

39. The imaging phantom of claim 30 wherein the oil is vegetable oil.

40. The tissue-mimicking material of claim 30 wherein the first, small diameter beads have a mean diameter of about 20 μ

m or less to influence primarily ultrasound and CT attenuation, and the second, large diameter beads have a mean diameter of 30 μ

m or larger to influence primarily ultrasound backscatter.

41. The imaging phantom of claim 30 wherein the first section is formed as a sphere to simulate prostate tissue, the third section is formed as a slab in contact with the first section to simulate fat tissue, and the second section is formed to surround the first section and the third section and simulates muscle and connective tissue.

42. The imaging phantom of claim 41 further including a closed ended cylindrical wall with an open interior that extends from a wall of the phantom container into the tissue-mimicking material in the container to simulate a rectum.

43. The imaging phantom of claim 42 further including a thin cylinder of tissue-mimicking material extending through the first section and into the material of the second section to simulate a urethra.