Ultrasonic method for indicating a rate of perfusion

• US 6,319,204 B1
• Filed: 01/26/2000
• Issued: 11/20/2001
• Est. Priority Date: 01/26/2000
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Poland, Mckee D, Brock-Fisher, George A
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): PATEL, MAULIN M
• Application Number:
  US09/491,707
• Time in Patent Office: 664 Days
• Field of Search: 600/458, 600/455, 600/439, 600/437, 600/438, 600/459
• US Class Current: 600/458
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039

Abstract

The method of the invention controls an ultrasound system to produce one or more images that indicate a rate of perfusion of a region of interest (ROI) of an area of anatomy. The method initially introduces a contrast agent into the ROI and derives, at a first time, an ultrasound image of the ROI. That image is processed to identify regions of the ROI that include the contrast agent. Thereafter, a first attribute, such as a color, is assigned to the region of the ROI that is identified as including the contrast agent. The ROI is again imaged after a discrete time interval and a second attribute (i.e., a second color) is assigned to identified regions of the ROI that include the contrast agent but have not previously had an attribute assigned thereto. This process is repeated a number of times, with each successive region of the ROI that manifests contrast agent being assigned a still different attribute. An image of the ROI is then displayed, with each of the attributes indicated thereon, that enables the user to determine, from the progression of the attributes across the image, the rate and type of re-perfusion that occurs in the ROI.

Claims

1. A method for controlling an ultrasound system to produce one or more images to indicate a rate of perfusion of an anatomical region of interest (ROI) into which a contrast agent has been introduced, said method comprising the steps of:

a) deriving a first ultrasound image of said ROI and processing the ultrasound image to identify regions of the ROI that include contrast agent;

b) assigning a first attribute to regions of the ROI identified in step a) as including contrast agent;

c) repeating steps a) and b) to derive at least a second ultrasound image of said ROI and assigning a not previously assigned attribute to identified regions of the ROI that are identified as including contrast agent and have not previously had an attribute assigned thereto; and

d) displaying an image that includes said ROI and respectively manifests said identified regions with said assigned attributes.

2. The method as recited in claim 1, wherein each said attribute is a different color.

3. The method as recited in claim 1, wherein step a) is preceded by the steps of:

infusing said anatomical region with a contrast agent; and

irradiating said ROI with an ultrasound beam of sufficient energy to destroy said contrast agent within said ROI.

4. The method as recited in claim 3, wherein said contrast agent comprises microbubbles of an encapsulated gas.

5. The method as recited in claim 1, wherein steps a) and b) are executed repetitively over a plurality of synchronized time intervals.

6. A memory media including instructions for operating a processor to control an ultrasound system to produce one or more images that indicate a rate of perfusion of an anatomical region of interest (ROI) into which a contrast agent is being perfused, said memory media comprising:

a) means for controlling said processor to derive a first ultrasound image of said ROI and to process the ultrasound image to identify regions of the ROI that include contrast agent;

b) means for controlling said processor to assign a first attribute to regions of the ROI identified in step a) as including contrast agent;

c) means for controlling said processor to repeat the operation of means b) and c) to derive at least a second ultrasound image of said ROI and to assign a not previously assigned attribute to identified regions of the ROI that are identified as including contrast agent and have not previously had an attribute assigned thereto; and

e) means for controlling said processor to cause display of an image that includes said ROI and respectively manifests said identified regions with said assigned attributes.

7. The memory media as recited in claim 6, wherein each said attribute is a different color.

8. The memory media as recited in claim 6, wherein means a) comprises:

means for controlling said processor to irradiate said ROI with an ultrasound beam of sufficient energy to destroy said contrast agent within said ROI.

9. The memory media as recited in claim 8, wherein said contrast agent comprises microbubbles of an encapsulated gas.

10. The memory media as recited in claim 6, wherein means a) and b) are caused to execute repetitively over a plurality of synchronized time intervals.

11. A method for processing and displaying a single ultrasound image of a region of interest (ROI) in a patient, comprising the steps of:

a) introducing a contrast agent into said patient;

b) applying an ultrasound beam to said ROI to destroy contrast agent in said ROI;

c) producing a single ultrasound image of said ROI having plural attributes, said attributes representing respective amounts of time required for a contrast agent to reperfuse into respective areas of the ROI, after said contrast agent has been destroyed.

12. The method as recited in claim 11, wherein each said attribute is a different color.

13. The method as recited in claim 11, wherein said contrast agent comprises microbubbles of an encapsulated gas.

14. The method as recited in claim 11, wherein step b) is executed repetitively over a plurality of time intervals that are synchronized with ROI motion so as to enable step c) to accurately map said plural attributes onto said ROI.