Drug delivery means

• US 6,319,245 B1
• Filed: 04/08/1999
• Issued: 11/20/2001
• Est. Priority Date: 10/09/1996
• Status: Expired due to Fees

• Current Assignee: Thomas John Berrigan
• Original Assignee: Thomas John Berrigan
• Inventors: Berrigan, Thomas John
• Primary Examiner(s): Kennedy, Sharon
• Assistant Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US09/269,950
• Time in Patent Office: 957 Days
• Field of Search: 604/9-10, 604/93, 604/95, 604/131-132, 604/151, 604/153, 604/175, 604/185, 604/118, 604/122-124, 604/890.1, 604/891.1
• US Class Current: 604/891.1
• CPC Class Codes: A61M 5/1428 with manual pumping action

Abstract

A drug delivery means comprising a holding reservoir (11), a pumping means (16), a delivery reservoir (23) and outlet (25), said holding reservoir (11) being connected to the delivery reservoir (23) through the pump (16) where the pump (16) is operable manually to effect transfer of fluid from the holding reservoir (11) to the delivery reservoir (23), the delivery reservoir (23) being connected to the outlet (25) through a flow restriction means (27) which controls the flow to the outlet (25), the delivery reservoir being formed to be resiliently expandable to a maximum volume and wherein the connection between the holding reservoir (11) and delivery reservoir (23) prevents pressurisation of the delivery reservoir (23) substantially beyond a predetermined pressure which will be achieved on the delivery reservoir (23) obtaining its maximum volume, a control means (30) provided with the delivery reservoir to prevent further pressurisation of the delivery reservoir (23) substantially beyond the predetermined pressure, said delivery reservoir (23) being accommodated within the holding reservoir (11).

Claims

1. A drug delivery device comprising a holding reservoir, a pump, a delivery reservoir and an outlet, said holding reservoir being connected to said delivery reservoir through said pump by a connection, said pump being operable manually whereby fluid is transferred from the holding reservoir to the delivery reservoir, said delivery reservoir being connected to the outlet through a flow restriction which controls flow to the outlet, said delivery reservoir being resiliently expandable to a maximum volume wherein the connection between the holding reservoir and the delivery reservoir permits flow only from the holding reservoir to the delivery reservoir while the pressure within the delivery reservoir is less than a maximum pressure, said connection having a control device for redirecting flow to the holding reservoir upon the pressure within the delivery reservoir attaining said maximum pressure, said delivery reservoir being accommodated within the holding reservoir.

2. A drug delivery device as claimed at claim 1 which is capable of a delivery by a generally constant flow rate between dosage occasions.

3. A drug delivery device as claimed by claim 2 wherein the delivery reservoir has a high volume relative to the flow rate of the flow restriction means.

4. A drug delivery device as claimed by claim 2 wherein the pressure induced on the fluid within the delivery reservoir between intended dosage occasions is generally constant.

5. A drug delivery device as claimed at claim 1 which is capable of a delivery by a decaying flow rate between dosage occasions.

6. A drug delivery device as claimed by claim 5 wherein the delivery reservoir has a low volume relative to the flow rate of the flow restriction.

7. A drug delivery device as claimed by claim 1 wherein a bacterial filter is provided between the delivery reservoir and the flow restriction.

8. A drug delivery device as claimed by claim 7 wherein the filter is adapted to enable gas to separate from the liquid passing to the filter and has a gas outlet for the gas which opens into the holding reservoir.

9. A drug delivery device as claimed by claim 7 wherein the filter is accommodated within the holding reservoir.

10. A drug delivery device as claimed by claim 1 wherein the holding reservoir is associated with a filling port.

11. A drug delivery device as claimed by claim 1 wherein the pump is accommodated on or within the holding reservoir.

12. A drug delivery device as claimed by claim 1 wherein the control comprises a first valve between the holding reservoir and the pump and a second valve between the pump and the delivery reservoir, said first and second valves permitting unidirectional flow to the pump and the delivery reservoir respectively when the delivery reservoir is not filled to its maximum volume and the pressure within the delivery reservoir is less than the predetermined pressure, the second valve permitting fluid flow to the holding reservoir when the pressure within the delivery reservoir is at least equal to the predetermined pressure.

13. A drug delivery device as claimed by claim 1 wherein the control comprises a unidirectional first valve between the holding reservoir and pump and a relief chamber between the pump and the first or second valve respectively, said relief chamber being resiliently expandable with the expandable portion of the wall of the relief chamber having a higher modulus of elasticity than the expandable portion of the delivery reservoir whereby the expandable portion of the relief chamber will expand on the pressure between the pump and the delivery reservoir being at least equal to the predetermined pressure.

14. A drug delivery device as claimed by claim 1 wherein the control comprises a relief valve communicating with the delivery reservoir which will permit the flow from the delivery reservoir to the holding reservoir where the fluid pressure in the delivery reservoir is at least equal to the predetermined pressure.

15. A drug delivery device as claimed by claim 13 wherein the valves are located within the holding reservoir.

16. A drug delivery device as claimed by claim 1 wherein the flow restriction is formed with a plurality of flow pathways.

17. A drug delivery device as claimed by claim 16 wherein the flow restriction comprises a plurality of capillary passageways or pores.

18. A drug delivery device as claimed by claim 16 wherein the flow restriction comprises a porous element which is formed of a glass, a ceramic or other material.

19. A drug delivery device as claimed by claim 16 wherein the flow restriction comprises a single flow path.