Composition and method for inhibiting oral bacteria

• US 6,319,523 B1
• Filed: 06/29/2000
• Issued: 11/20/2001
• Est. Priority Date: 06/29/2000
• Status: Expired due to Fees

• Current Assignee: Herbasway Laboratories, LLC
• Original Assignee: Herbasway Laboratories, LLC
• Inventors: Zhou, James H.
• Primary Examiner(s): Lilling, Herbert J.
• Application Number:
  US09/606,294
• Time in Patent Office: 509 Days
• Field of Search: 424/195.1, 424/725, 424/729, 424/735, 424/752, 424/757, 424/706, 424/776, 424/777
• US Class Current: 424/725
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/15 Pinaceae (Pine family), e.g. pine or cedar
• CPC Class Codes: A61K 36/16 Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/24 Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
• CPC Class Codes: A61K 36/42 Cucurbitaceae (Cucumber family)
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/484 Glycyrrhiza (licorice)
• CPC Class Codes: A61K 36/54 Lauraceae (Laurel family), e.g. cinnamon or sassafras
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 36/704 Polygonum, e.g. knotweed
• CPC Class Codes: A61K 36/708 Rheum (rhubarb)
• CPC Class Codes: A61K 36/73 Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• CPC Class Codes: A61K 36/736 Prunus, e.g. plum, cherry, peach, apricot or almond
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/87 Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: A61K 36/889 Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto

Abstract

A composition for inhibiting oral bacteria, including a polyphenol derivative composition; and at least one composition selected from the group consisting of mogroside derivative composition, licorice extract and combinations thereof, wherein the composition is effective to inhibit growth of oral microbials.

Claims

1. A composition for inhibiting oral bacteria, comprising:

a polyphenol composition containing at least one polyphenol selected from the group consisting of Catechin, resveratrol and combinations thereof;

a mogroside composition standardized to contain at least about 2% weight of mogroside V; and

a licorice extract, said licorice being an organic solvent soluble and water insoluble fraction;

wherein said composition contains at least about 0.05% w/v of said polyphenol composition, at least about 0.01% w/v of said mogroside composition and at least about 0.001% w/v of said licorice extract.

2. A method for inhibiting oral bacteria, comprising the steps of:

providing a composition according to claim 1; and

orally administering said composition to a mammal, whereby oral microbials are inhibited and suppressed from genetically altering.

3. The composition according to claim 1, wherein said composition contains said polyphenol composition, said mogroside composition and said licorice extract in amounts per unit composition as follows:

polyphenol composition 0.5-10 mg

mogroside composition 0.1-1 mg

licorice extract 0.01-5 mg.

4. The composition according to claim 1, wherein said polyphenol composition comprises Catechin.

5. The composition according to claim 4, wherein said Catechin is obtained from at least one botanical source selected from the group consisting of Camellia spp., Acacia catechu, Polygonum spp., Areca catechu, Potentilla fragarioides, Rheum, Prunus, Ginkgo biloba, Machilus, Elaeagnus, Apocynum, Geranium, and combinations thereof.

6. The composition according to claim 4, wherein said polyphenol composition further comprises resveratrol.

7. The composition according to claim 6, wherein said resveratrol is obtained from at least one source selected from the group consisting of polygonum spp., grape vine, fruit, seed and skin;

peanut;

pine and combinations thereof.

8. The composition according to claim 1, wherein said polyphenol composition is standardized to contain at least about 2% wt polyphenol compounds.

9. The composition according to claim 1, wherein said polyphenol composition is standardized to contain at least about 80% wt polyphenol compounds.

10. The composition according to claim 1, wherein said mogroside composition comprises an extract of Momordica grosvenorii.

11. The composition according to claim 1, wherein said mogroside composition is standardized to contain at least about 40% wt of mogroside compounds.

12. The composition according to claim 1, wherein said mogroside composition is standardized to contain at least about 80% weight of mogroside compounds.

13. The composition according to claim 1, wherein said mogroside composition is standardized to contain at least about 30% weight of mogroside V.

14. The composition according to claim 1, wherein said licorice extract comprises licorice root extract.

15. The composition according to claim 1, wherein said licorice extract comprises extract obtained from a source selected from the group consisting of Glycyrrhiza uralensis, G. glabra, G. kansuesis, G. inflata and combinations thereof.